A5101786270- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Pediatric health and respiratory diseases
- Cancer-related molecular mechanisms research
- Ocular Infections and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Asthma and respiratory diseases
- High Temperature Alloys and Creep
- Cancer, Lipids, and Metabolism
- Extracellular vesicles in disease
- Neonatal Health and Biochemistry
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- Ocular Surface and Contact Lens
- Nanoplatforms for cancer theranostics
- Legionella and Acanthamoeba research
- Autophagy in Disease and Therapy
- Wound Healing and Treatments
- Gut microbiota and health
- Parasitic Diseases Research and Treatment
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Marine and coastal ecosystems
- Advanced Materials Characterization Techniques
Hangzhou Medical College
2023-2025
Wuhan University of Science and Technology
2024-2025
Inner Mongolia Medical University
2015-2025
Beijing Tongren Hospital
2023-2024
Capital Medical University
2022-2024
Air Force Medical University
2020-2024
Nanjing University of Chinese Medicine
2020-2024
Soochow University
2023-2024
First Affiliated Hospital of Zhengzhou University
2009-2024
Harbin Medical University
2022-2023
Background Thyroid hormones play a vital role in maintaining the homeostasis of cardiovascular system. The FT3/FT4 ratio can be used to evaluate rate T4-to-T3 conversion, reflecting peripheral sensitivity thyroid hormones. There is no study investigate its relationship with death and disease (CVD) general population. Methods This retrospective cohort involved 8,018 participants measured function prior who participated National Health Nutrition Examination Survey (NHANES) from 2007 2012....
Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor, has been extensively demonstrated to be associated with metabolic disorders, including obesity and type 2 diabetes mellitus. However, the underlying mechanism underpinning etiology of chronic disorders not sufficiently elucidated.This study is designed explore toxicological pathogenesis inflammation in BPA exposure during obesity.We investigated role IL-17A association from human cross-sectional animal models, genetically...
To investigate the efficacy and mechanisms of human umbilical cord-derived MSC-derived extracellular vesicles (hucMSC-EVs) in a mouse model desiccation-induced dry eye disease (DED).hucMSC-EVs were enriched by ultracentrifugation. The DED was induced desiccating environment combined with scopolamine administration. mice divided into hucMSC-EVs group, fluorometholone (FML) PBS blank control group. Tear secretion, corneal fluorescein staining, cytokine profiles tears goblet cells,...
As yet, there was no effective pharmacological therapy approved for non-alcoholic fatty liver disease (NAFLD). Here, we aimed to evaluate the therapeutic potential of puerarin against NAFLD and explored underlying mechanisms. C57BL/6J mice were fed with a high-fat high-sucrose (HFHS) diet or without coadministration intragastrically. The levels hepatocellular injury, steatosis, fibrosis, mitochondrial metabolism alteration detected. First, ameliorated histopathologic abnormalities due HFHS....
Tumor microenvironment (TME) plays a very important role in cancer progression. The mesenchymal stem cells (MSC), major compartment of TME, have been shown to promote hepatocellular carcinoma (HCC) progression and metastasis. As hypoxia is common feature it essential investigate the effects on MSC during HCC progression.The mediated cell proliferation were measured by counting kit-8 (CCK-8) assay, Edu incorporation assay xenograft model. cyclooxygenase 2 (COX2) this process was evaluated via...
Ischemia reperfusion injury (IRI) has been shown to increase the risk of tumor recurrence after liver surgery. Also, nonalcoholic fatty disease (NAFLD) is associated with increased HCC recurrence. ALOX12-12-HETE pathway activated both in IRI and NASH. mediate tumorigenesis progression. Therefore, our study aims investigate whether ALOX12-12-HETE-GPR31 involved induced NAFLD.HCC mouse model was used mimic NAFLD. Western Blot, qPCR, Elisa Immunofluorescence analysis were conducted evaluate...
Claudin1 plays a critical role in maintaining the epithelial barrier, and mucus hypersecretion induced by epidermal growth factor receptor (EGFR) activation is pivotal pathological feature of asthma. The relationship between claudin1 expression EGFR still poorly understood. In this report, we showed that correlated with asthma stage, both patients house dust mite (HDM)-induced mouse model. knockdown MUC5AC overexpression 16HBE cells airways. addition, negatively severity as demonstrated...
Purpose: Fungal keratitis (FK) is a serious corneal infection with high morbidity. Host immune responses function as double-edged sword by eradicating fungal pathogens while also causing damage, dictating the severity, progression, and outcome of FK. However, underlying immunopathogenesis remains elusive. Methods: Time-course transcriptome was performed to illustrate dynamic landscape in mouse model Integrated bioinformatic analyses included identification differentially expressed genes,...
Cancer cell metastasis is one of the major causes patients death with hepatocellular carcinoma (HCC). Previous findings demonstrated that protrusion-accumulated STAT3 mRNA highly related to HCC metastasis, making protrusion-localized an ideal biomarker for evaluating initiation and progression. A self-powered lipidic nanoflare (SLNF) has been developed detecting expression level in individual cells, which enables accurate prediction metastasis. The LNF system a cholesterol micelle decorated...
Prolonged chronic wound healing not only places great stress on patients but also increase the health care burden. Fortunately, emergence of tissue-engineered dressings has provided a potential solution for these patients. Recently, relationship between microenvironment and been gradually clarified. Therefore, state wounds can be roughly ascertained by monitoring in real time. Here, we designed three-layer integrated smart dressing, including biomimetic nanofibre membrane, sensor...
Summary Wound infection is a challenging clinical problem that imposes substantial economic and psychological burdens on patients. However, the wound covered by dressing in an ‘unknown’ state. Recently, researchers have focused understanding condition of without removing dressing. Here, we presented flexible integrated sensing platform (FISP) can monitor multiple indicators, including local temperature. The consists sensor chip (FSC), controlled printed circuit board (CPCB) customized...
Objective: To investigate the correlation between structure and function alterations of gut microbiota biochemical indicators in males with hyperuricemia (HUA) high levels liver enzymes, order to provide new evidences therapeutic targets for clinical diagnosis treatment HUA. Methods: A total 69 patients HUA (HUA group) 118 healthy controls were enrolled this study. Their age, height, waist circumference, weight, pressure measured. The parameters such as fasting plasma glucose (FBG),...
Anticoagulant surface modification of blood-contacting materials has been shown to be effective in preventing thrombosis and reducing the dose anticoagulant drugs that patients take. However, commercially available coatings, is, both bioinert bioactive are typically based on a single anticoagulation strategy. This puts function coating at risk failure during long-term use. Considering several pathways human coagulation system, synergy multiple theories may provide separate, targeted effects...
Image ordinal estimation is to predict the label of a given image, which can be categorized as an regression problem. Recent methods formulate problem series binary classification problems. Such cannot ensure that global relationship preserved since relationships among different classifiers are neglected. We propose novel approach, termed Convolutional Ordinal Regression Forest or CORF, for image estimation, integrate and differentiable decision trees with convolutional neural network...