A5100377764- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Receptor Mechanisms and Signaling
- Radiation Therapy and Dosimetry
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuropeptides and Animal Physiology
- Neurotransmitter Receptor Influence on Behavior
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neural Engineering
- Pharmacological Effects of Natural Compounds
- Carbon Nanotubes in Composites
- Plant-based Medicinal Research
- Effects and risks of endocrine disrupting chemicals
- Muscle activation and electromyography studies
- Antimicrobial Peptides and Activities
- Axon Guidance and Neuronal Signaling
- Pain Mechanisms and Treatments
- Advanced Radiotherapy Techniques
- Advanced Antenna and Metasurface Technologies
- Graphene and Nanomaterials Applications
- Wound Healing and Treatments
- Electromagnetic wave absorption materials
- Microtubule and mitosis dynamics
- Anesthesia and Neurotoxicity Research
Hainan University
2024-2025
First Affiliated Hospital of Xinxiang Medical University
2025
Shandong Agricultural University
2025
Shenyang Pharmaceutical University
2005-2024
Third Xiangya Hospital
2024
Central South University
2024
Tongji Hospital
2024
National Clinical Research Center for Digestive Diseases
2024
Ministry of Education of the People's Republic of China
2024
Huazhong University of Science and Technology
2024
Background: Depression is a mental disorder that poses serious threat to human health.Adult hippocampal neurogenesis (AHN) closely associated with the efficacy of antidepressants.Chronic treatment corticosterone (CORT), well-validated pharmacological stressor, induces depressive-like behaviors and suppresses AHN in experimental animals.However, possible mechanisms chronic CORT action remain elusive.Methods: A (0.1 mg/mL, drinking water for 4 weeks) was applied prepare mouse model...
Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor, has been extensively demonstrated to be associated with metabolic disorders, including obesity and type 2 diabetes mellitus. However, the underlying mechanism underpinning etiology of chronic disorders not sufficiently elucidated.This study is designed explore toxicological pathogenesis inflammation in BPA exposure during obesity.We investigated role IL-17A association from human cross-sectional animal models, genetically...
To avoid the production of drug resistance during antibiotic treatment wound infection, use antimicrobial peptides (AMPs) has been strongly developed. However, its application is limited by low bioavailability, rapid degradation AMP, and difficulty deep-tissue bacterial elimination. solve this problem, AMP recombinant type III humanized collagen (Col III)-contained microneedle patches were designed to achieve slow controlled release Col effectively eliminate bacteria in deep tissue promote...
ABSTRACT Oyster mushrooms are grown commercially worldwide, especially in many developing countries, for their easy cultivation and high biological efficiency. Cap color is an important commercial trait oyster mushrooms. Little known about the genetic mechanism of cap mushrooms, which limits molecular breeding improvement color-type cultivars. In this study, candidate gene, pcmfs , mushroom Pleurotus cornucopiae was identified based on results QTL (quantitative loci) mapping comparative...
Background: Radiotherapy plays a central role in therapeutic strategy of local-advanced oesophageal squamous cell carcinoma. The aim this study was to investigate cytokine profiles serum patients with ESCC and evaluate the potential utility markers predicting CRT response prognostic prediction. Methods: CCL4, MIF CXCL8 samples who were participating phase II clinical trial (NCT02959385) determined. association between these cytokines as well prediction subsequently assessed ESCC....
Morphine is a well-known μ-opioid receptor (MOR) agonist and an efficient analgesic, but its long-term use inevitably leads to drug addiction tolerance. Here, we show that specific inhibition of β-arrestin2 with siRNA lentivirus microinjected in mice periaqueductal gray matter (PAG) significantly improved both acute chronic morphine analgesia delayed the tolerance hotplate test. The effect was proven by overexpression or knockdown homology β-arrestin1 PAG, which showed no significant effects...
Baicalin, the main active flavonoid constituent of Scutellaria baicalensis Georgi, has been reported to exert antidepressant effects. Hypothalamic-pituitary-adrenal (HPA) axis plays important roles in depression. However, effect and mechanism baicalin on HPA hypothalamus are still unknown. In present study, we find significantly attenuates increase immobility time tail suspension forced swimming, improves decrease spending open arms, restores aberrant negative feedback chronic corticosterone...
EBT-XD model of Gafchromic
The purpose of this study was to develop poly(amidoamine) (PAMAM)-functionalized multi-walled carbon nanotubes (MWNTs) loaded with a poorly water-soluble drug, intended improve the drug-loading capacity, dissolution and design sustained release system. MWNTs were modified carboxyl group by acid treatment then complex PAMAM. PAMAM-MWNTs investigated as scaffold for loading model Carvedilol (CAR), using three different methods (the fusion method, incipient wetness impregnation solvent method)....
β-arrestins, key regulators of receptor signaling, are highly expressed in the central nervous system, but their roles brain physiology largely unknown. Here we show that β-arrestin-2 is critically involved formation associative fear memory and amygdalar synaptic plasticity. In response to conditioning, translocates membrane where it interacts with PDE-4, a cAMP-degrading enzyme, inhibit PKA activation. Arrb2 −/− mice exhibit impaired conditioned long-term potentiation at lateral synapses....
Signal-regulated changes in cell size affect division and survival therefore are central to tissue morphogenesis homeostasis. In this respect, GABA receptors (GABA(A)Rs) of particular interest because allowing anions flow across the membrane modulates osmolyte flux volume. Therefore, we have here investigated hypothesis that may regulate neural stem proliferation by inducing changes. We found that, besides neuroblasts, also precursors neonatal murine subependymal zone sense via GABA(A) Rs....
Wallerian degeneration (WD) in injured peripheral nerves is associated with a large number of up- or down-regulated genes, but the effects these changes are poorly understood. In our previous studies, we reported some key factors that differentially expressed to activate nerve and regeneration during WD. Here, determined secreted phosphoprotein 1 (Spp1) on WD after rat sciatic injury. Spp1 was upregulated from 6 h 14 days Altered expression Schwann cells (SC) resulted altered mRNA protein...
During embryonic development of the mammalian cerebral cortex, postmitotic cortical neurons migrate radially from ventricular zone to plate. Proper migration involves correct orientation migrating and transition a multipolar mature bipolar morphology. Herein, we report that 2 isoforms Myosin-10 (Myo10) play distinct roles in regulation radial mouse cortex. We show full-length Myo10 (fMyo10) isoform is located deeper layers cortex involved establishing proper orientation. also demonstrate...