A5036850507- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Luminescence Properties of Advanced Materials
- Corrosion Behavior and Inhibition
- Advanced biosensing and bioanalysis techniques
- Click Chemistry and Applications
- Cholinesterase and Neurodegenerative Diseases
- Advanced materials and composites
- Nanocluster Synthesis and Applications
- Glass properties and applications
- Advanced Sensor and Energy Harvesting Materials
- Cancer Research and Treatments
- Graphene and Nanomaterials Applications
- Adenosine and Purinergic Signaling
- Hydrogen embrittlement and corrosion behaviors in metals
- Advanced Photocatalysis Techniques
- Microbial bioremediation and biosurfactants
- Solid State Laser Technologies
- Luminescence and Fluorescent Materials
- Metallurgical Processes and Thermodynamics
- Advanced Surface Polishing Techniques
- Dielectric materials and actuators
- Computational Drug Discovery Methods
- Peptidase Inhibition and Analysis
- Ferroelectric and Piezoelectric Materials
Allen Institute for Brain Science
2024-2025
Icahn School of Medicine at Mount Sinai
2024-2025
China Construction Eighth Engineering Division (China)
2025
Anyang Normal University
2022-2025
Nanyang Normal University
2022-2025
Hainan Normal University
2025
Hainan University
2025
Pharmaceutical Biotechnology (Czechia)
2025
Guangxi University
2023-2025
Changchun Institute of Applied Chemistry
2018-2024
Metal–organic frameworks (MOFs)-based peroxidase mimics have been seldom applied in the biomedical field, especially vivo. One of main reasons is their optimum reactions occur strong acidic environments with a pH 3–4, severely limiting applications living systems where neutral usually required. Other types also suffer such fatal defect. Additionally, direct introduction relatively high concentrated and toxic reaction reagent H2O2 would induce undesired damage to normal tissues. Herein,...
Abstract Metal–organic frameworks (MOFs) have sparked increasing interest in mimicking the structure and function of natural enzymes. However, their catalytic therapeutic efficiency are unsatisfactory due to relatively lower activity. Herein, inspired by nature, a MOF@COF nanozyme has been designed as high‐efficiency peroxidase mimic, with metallic nodes MOFs active centres, hierarchical nanocavities produced growth covalent organic (COFs) binding pockets form tailored pore microenvironment...
Abstract The widespread multidrug resistance resulting from the abuse of antibiotics motivates researchers to explore alternative methods treat bacterial infections. Recently, emergence nanozymes has provided a potential approach combat bacteria. Such can mimic functions natural enzymes induce production highly toxic reactive oxygen species (ROS) as an antibacterial. However, lack effective interaction between and bacteria, intrinsic short lifetime diffusion distance ROS greatly compromise...
Abstract Recently, antimicrobial photodynamic therapy (aPDT) has been considered as an attractive treatment option for biofilms ablation. However, even very efficient photosensitizers (PSs) still need high light doses and PS concentrations to eliminate due the limited penetration diffusion of PSs in biofilms. Moreover, hypoxic microenvironment rapid depletion oxygen during PDT severely limit their therapeutic effects. Herein, first time, a porphyrin‐based metal organic framework (pMOF)...
Salt stress is an important environmental limiting factor. Water dropwort ( Oenanthe javanica ) vegetable in East Asia; however, its phenotypic and physiological response poorly explored. For this purpose, 48 cultivars of water were grown hydroponically treated with 0, 50, 100, 200 mm NaCl for 14 days. Than their responses evaluated, afterward, studies carried out selected sensitive tolerant cultivars. In the present study, potential (V11E0022) (V11E0135) by screening based on phenotype...
As a typical bioorthogonal reaction, the copper-catalyzed azide-alkyne cycloaddition (CuAAC) has been used for drug design and synthesis. However, localized synthesis, it is important to be able determine where CuAAC reaction occurs in living cells. In this study, we constructed heterogeneous copper catalyst on metal-organic framework that could preferentially accumulate mitochondria of Our system enabled synthesis drugs through site-specific with good biocompatibility. Importantly,...
A novel sprayable adhesive is established (ZnMet-PF127) by the combination of a thermosensitive hydrogel (Pluronic F127, PF127) and coordination complex zinc metformin (ZnMet). Here we demonstrate that ZnMet-PF127 potently promotes healing traumatic skin defect burn injury promoting cell proliferation, angiogenesis, collagen formation. Furthermore, find ZnMet could inhibit reactive oxygen species (ROS) production through activation autophagy, thereby protecting from oxidative stress induced...
Personalized tumor vaccines have become a promising modality for cancer immunotherapy. However, in situ personalized generated from immunogenic cell death (ICD) and adjuvants are mired by toxic side effects unsatisfactory efficiency. Herein, functionalizing the reticular structure to optimize catalytic activity of materials, series biocompatible covalent organic framework (COF)-based catalysts been designed screened establishing bioorthogonal-activated vaccine an efficient safe way....
Pyroptosis is an inflammatory form of programmed cell death that holds great promise in cancer therapy. However, autophagy as the crucial pyroptosis checkpoint and self-protective mechanism cells significantly weakens therapeutic efficiency. Here, a bioorthogonal nanoregulator constructed to induce disrupt checkpoint, enabling high-efficiency The allows situ synthesis accumulation photosensitizer PpIX mitochondria directly produce mitochondrial ROS, thus triggering pyroptosis. Meanwhile,...
The formation of bacterial biofilm is one the causes antimicrobial resistance, often leading to persistent infections and a high fatality rate. Therefore, there an urgent need develop novel effective strategies inhibit formation. Adenosine triphosphate (ATP) plays important role in adhesion through stimulating cell lysis extracellular DNA (eDNA) release. Herein, simple robust strategy for inhibiting developed using CeO2 -decorated porphyrin-based metal-organic frameworks (MOFs). function ATP...
Abstract Background Circular RNAs (circRNAs) are involved in diverse processes that drive cancer development. However, the expression landscape and mechanistic function of circRNAs osteosarcoma (OS) remain to be studied. Methods Bioinformatic analysis high-throughput RNA sequencing tools were employed identify differentially expressed between OS adjacent noncancerous tissues. The level circ_001422 clinical specimens cell lines was measured using qRT-PCR. association with clinicopathologic...
Metabolic glycan labeling (MGL) followed by bioorthogonal chemistry provides a powerful tool for tumor imaging and therapy. However, selectively metabolic of cells or tissues interest remains challenge. Particularly, owing to heterogeneity including subtypes interpatient heterogeneity, it is far more difficult realize tumor-cell-selective precise diagnosis. Inspired nature, we designed azidosugar-functionalized metal-organic frameworks camouflaged with cancer cell membranes accomplish...
Significance Cell-surface glycans are dynamic indicators reporting cell physiological state and pathological processes including occurrence progression of disease (e.g., cancer). For precise cancer diagnosis treatment, however, it’s difficult to selectively visualize different cells or subtypes. Herein, we demonstrate the feasibility membrane–camouflaged azidosugar liposomes for cell–selective metabolic glycoengineering. The biomimetic inherit selectivity homotypic cells. Therefore, they...
Bioorthogonal reactions provide a powerful tool to manipulate biological processes in their native environment. However, the transition-metal catalysts (TMCs) for bioorthogonal catalysis are limited low atomic utilization and moderate catalytic efficiency, resulting unsatisfactory performance complex physiological Herein, sulfur-doped Fe single-atom with atomically dispersed uniform active sites fabricated serve as potent (denoted Fe-SA), which situ manipulation of cellular processes. As...
Abstract Venous hypertension(VH) plays an important role in the pathogenesis of cerebral arteriovenous malformations (AVMs) and is closely associated with HIF-1α/VEGF signaling pathway. Nuclear factor erythroid 2-related 2(Nrf2) significantly influences angiogenesis; however, interplay between Nrf2 VEGF under VH brain AVMs remains unclear. Therefore, our study aimed to investigate due AVMs. Immunohistochemistry indicated that were highly expressed human AVM tissues. In vivo , we established...
As a burgeoning bioorthogonal reaction, the fluoride-mediated desilylation is capable of prodrug activation. However, due to reactions lack cell selectivity and unitary therapy modality, this strongly impedes their biomedical applications. Herein, we construct cancer cell-selective biomimetic metal–organic framework (MOF)-F platform for activation enhanced synergistic chemodynamic (CDT). With membranes camouflage, designed nanocatalyst displays preferential accumulation homotypic cells....
Since polyoxometalates (POMs) can undergo reversible multi-electron redox transformations, they have been used to modulate the electronic environment of metal nanoparticles for catalysis. Besides, POMs possess unique structures and acid-responsive self-assembly ability. These properties inspired us tackle drawbacks copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction in biomedical applications, such as low catalytic efficiency unsatisfactory disease selectivity. Herein, we construct...