Palladium-catalyzed C(sp²)–H methylation and acylation <italic>via</italic> anodic oxidation have been developed to avoid the use of stoichiometric chemical oxidants.

Although broad-spectrum antibacterial agents have been developed for treatment, the balance of microbial flora may break and this usually results in increasing resistance. To end, developing simple effective strain-selective bactericidal strategies are demanding. Herein we designed an intelligent Gram-selective antimicrobial system based on MoS2 a photoacid molecule. This can be modulated by light surface charge conversion from negative to positive simultaneously activation enzymatic...

Sensing bacterial infections and monitoring drug resistance are very important for the selection of treatment options. However, common methods sensing limited by time-consuming, requirement professional personnel, expensive instruments. Moreover, abuse antibiotics causes accelerated process resistance. Herein, we construct a portable paper-based band-aid (PBA) which implements selective antibacterial strategy after The colors PBA indicate infection (yellow) (red), just like colorimetric...

Abstract Recently, quorum sensing (QS) inhibitors (QSIs) have been combined with antibiotics to enhance antibiofilm efficacy in vitro and vivo. However, targeting QS signals alone is not enough prevent bacterial infections. Drug resistance recurrence of biofilms makes it difficult eradicate. Herein, photodynamic therapy (PDT) selected unite QSIs antibiotics. A synergistically system, which combines QSIs, antibiotics, PDT based on hollow carbon nitride spheres (HCNSs) envisaged. First, HCNS...

Although chemotherapy is one of the most widely used cancer treatments, there are serious side effects, drug resistance, and secondary metastasis. To address these problems, herein we designed a bimetallic metal-organic framework (MOF) encapsulated with DNAzyme for co-triggered in situ synthesis DNAzyme-based gene therapy. Once cells, MOFs would disassemble liberate copper ions, zinc under acidic environment lysosomes. Copper ions can catalyze chemotherapeutic through copper-catalyzed...

Palladium-catalyzed transfer semihydrogenation of alkynes using H2O as the hydrogen source and Mn reducing reagent is developed, affording cis- trans-alkenes selectively under mild conditions. In addition, this method provides an efficient way to access various cis-1,2-dideuterioalkenes trans-1,2-dideuterioalkenes by D2O instead H2O.

Abstract The intelligent nanomachine usually has a control center to carry out self‐regulation. Unfortunately, most of the nanomaterials for chemodynamic therapy (CDT) do not have such sense and process chemical or biological signals, which greatly weakens selectivity efficiency CDT. To address this problem, here an was constructed with DNAzyme logic gate as center, metal organic framework actuator. well‐designed showed enhanced killing effect on cancer cells but posed no harm normal cells,...

Although cancer immunotherapy based on immune checkpoint blockade has shown promising clinical responses, the limited host response rate and systemic side effects still restrict efficacy. To address these challenges, here, we construct an aptamer-functionalized metal-organic framework (MOF) catalyst for bioorthogonal activation of Toll-like receptors (TLR) 7 agonists programmed death-ligand 1 (PDL1) enhanced antitumor immunotherapy. The contains ultrasmall Pd nanoparticles enabling local...

The development of efficient and practical methods to construct carboxylic acids using CO2 as a C1 synthon is great importance. Nickel-catalyzed carboxylation aryl fluorosulfates heteroaryl with described, affording arene good excellent yields under mild conditions. In addition, one-pot phenol fluorosulfation/carboxylation developed.

Bacterial infectious diseases seriously threaten public health and life. The specific interaction between an antibody its multivalent antigen is attractive way to defeat disease. However, due the high expense strict storage applied conditions for antibodies, it highly desirable but remains urgent challenge disease diagnosis treatment construct artificial antibodies with strong stability binding ability excellent selectivity. Herein, we designed synthesized antibody-like bio-orthogonal...

As a burgeoning bioorthogonal reaction, the fluoride-mediated desilylation is capable of prodrug activation. However, due to reactions lack cell selectivity and unitary therapy modality, this strongly impedes their biomedical applications. Herein, we construct cancer cell-selective biomimetic metal–organic framework (MOF)-F platform for activation enhanced synergistic chemodynamic (CDT). With membranes camouflage, designed nanocatalyst displays preferential accumulation homotypic cells....

The creation of artificial high-performance photosynthetic assemblies with a tailorable antenna system to deliver absorbed solar energy reaction center, thereby mimicking biological photosynthesis, remains major challenge. We report the construction recyclable, nanofibers crystalline π-conjugated polyfluorene core as an that funnels spatially defined sensitized Co(II) porphyrin photocatalysts for hydrogen evolution reaction. Highly effective funneling was achieved by tuning dimensions...

Phosphine-catalyzed [4 + 2] cycloaddition of unsaturated pyrazolones with allenoates providing concise access to spiropyrazolones.

Controlled living crystallization driven self-assembly (CDSA) of poly(dimethyltrimethylene carbonate)- b -poly(ethylene glycol) (PDTC- -PEG) yields uniform two-dimensional (2D) platelets with excellent biocompatibility.

Bacterial infections present a major threat to global health every year. The antibiotic treatment can easily lead multidrug resistance. Despite great efforts devoted improving the activity of existing antibiotics or developing new antibiotics, innate ability bacteria develop resistance has exceeded rate development which indicates that strategies long-term antimicrobial therapies are ultimately doomed fail. Therefore, it is very important ways fight bacteria. Inspired by recent advances on...

Abstract Although chemotherapy is one of the most widely used cancer treatments, there are serious side effects, drug resistance, and secondary metastasis. To address these problems, herein we designed a bimetallic metal–organic framework (MOF) encapsulated with DNAzyme for co‐triggered in situ synthesis DNAzyme‐based gene therapy. Once cells, MOFs would disassemble liberate copper ions, zinc under acidic environment lysosomes. Copper ions can catalyze chemotherapeutic through...

Tert-butyl hydroperoxide (t-BHP), an analog of hydroperoxide, induced characteristic changes senescence in human diploid fibroblasts WI-38 cells. It was reported that ginsenoside Rg1, active ingredient ginseng, ameliorated learning deficits aged rats. The present study aimed to investigate whether Rg1 can delay the premature cells by t-BHP and explore underlying molecular mechanisms. First, pretreatment markedly reversed senescent morphological t-BHP. Second, treatment alone resulted...

Precise manipulation of chromatin folding is important for understanding the relationship between three-dimensional genome and nuclear function. Existing tools can reversibly establish individual loops but fail to manipulate two or more loops. Here, we engineer a powerful CRISPR system which multiple contacts using bioorthogonal reactions, termed reaction-mediated programmable loop (BPCL) system. The multiinput BPCL employs engineered single-guide RNAs recognized by discrete adaptors...