A5102905625- Pesticide Residue Analysis and Safety
- Analytical Chemistry and Chromatography
- COVID-19 Clinical Research Studies
- Genomics and Phylogenetic Studies
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Analytical chemistry methods development
- Gut microbiota and health
- Traditional Chinese Medicine Analysis
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Glycosylation and Glycoproteins Research
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- Nitric Oxide and Endothelin Effects
- Liver Diseases and Immunity
- Food Quality and Safety Studies
- Immunotherapy and Immune Responses
- Respiratory viral infections research
- Pharmacological Effects and Assays
- Probiotics and Fermented Foods
- Mycotoxins in Agriculture and Food
- Natural product bioactivities and synthesis
- Gastrointestinal disorders and treatments
- Pediatric Hepatobiliary Diseases and Treatments
Sun Yat-sen University
2005-2025
Tianjin Medical University
2024-2025
Anhui Medical University
2025
Jiangsu University
2016-2025
Guangxi University
2025
Qinghai University
2016-2024
Shanghai Jiao Tong University
2012-2024
Chengdu University of Traditional Chinese Medicine
2012-2024
Nanjing Agricultural University
2024
Northwest A&F University
2024
Increasing evidence suggests a correlation between glycosylation and the onset of cancer. However, clinical relevance glycosylation-related genes (GRGs) in uveal melanoma (UM) is yet to be fully understood. This study aimed shed light on impact GRGs UM prognosis.To identify most influential UM, we employed AUCell WGCNA algorithms. The signature was established by integrating bulk RNA-seq scRNA-seq data. patients were separated into two groups based their risk scores, GCNS_low GCNS_high...
The 2019 coronavirus disease (COVID-19) was first identified in Wuhan, Hubei, China December 2019, caused by a novel (SARS-CoV-2). There is need to study the clinical features of patients hospital near Wuhan.
Programmed cell-death protein 1 (PD-1) and programmed death-ligand (PD-L1) pathway blockade is a promising therapy for the treatment of advanced cancers, including B-cell lymphoma. The clinical response to PD-1/PD-L1 immunotherapy correlates with PD-L1 levels on tumor cells other in microenvironment. Hence, it important understand molecular mechanisms that regulate expression. Here, we report histone deacetylase 3 (HDAC3) crucial repressor transcription Pan-HDACs or selective HDAC3...
The gut-lung axis has been implicated as a potential therapeutic target in lung disorders. While increasing evidence suggests that gut microbiota plays critical role regulating host immunity and contributing to tuberculosis (TB) development progression, the underlying mechanisms whereby may impact TB outcomes are not fully understood. Here, we found broad-spectrum antibiotics treatment increased susceptibility Mycobacterium (M. tuberculosis) infection modulated pulmonary inflammatory...
Background Uveal melanoma (UVM) is the most common primary intraocular malignancy in adults and highly metastatic, resulting a poor patient prognosis. Sphingolipid metabolism plays an important role tumor development, diagnosis, This study aimed to establish reliable signature based on sphingolipid genes (SMGs), thus providing new perspective for assessing immunotherapy response prognosis patients with UVM. Methods In this study, SMGs were used classify UVM from TCGA-UVM GEO cohorts. Genes...
Lung adenocarcinoma (LUAD) is a heterogeneous disease with dismal prognosis for advanced tumors. Immune-associated cells in the microenvironment substantially impact LUAD formation and progression, which has gained increased attention recent decades. Sphingolipids have profound on tumor immune infiltration. However, few researchers focused utilization of sphingolipid variables prediction prognosis. The goal this work was to identify major sphingolipid-related genes (SRGs) develop valid...
Lack of a convenient and sustainable power supply device failure after material damage are important factors limiting the development traditional wearable sensors. In this study, self-healing triboelectric nanogenerator (TENG) was designed prepared for motion sensing energy harvesting. Hydrogen bonds disulfide were introduced into polyurethane (PU) chain segment to provide it with ability. Then, carbon nanotubes (CNTs) added PU confer electrical conductivity composite film. The conductive...
Abstract Harnessing solar energy to enhance the rechargeable zinc–air batteries (RZABs) performance is a promising avenue toward sustainable storage and conversion. Simultaneously enhancing light-absorption capacity carrier separation efficiency in nanomaterials, as well improving electrical conductivity configuration for electrocatalysis, presents formidable challenge due inherent trade-offs interdependencies. Here, we have developed Janus dual-atom catalyst (JDAC) with bifunctional centers...
// Mengchu Zhu 1,* , Mei Wang Fang Yang 1 Yiqing Tian Jie Cai Huan Hailong Fu Fei Mao Wei Hui Qian and Wenrong Xu Key Laboratory of Medical Science Medicine Jiangsu Province, School Medicine, University, Zhenjiang, Jiangsu, China * These authors have contributed equally to this work Correspondence to: Wang, email: Xu, Keywords : mesenchymal stem cells, gastric cancer, microRNA, tumor microenvironment Received August 06, 2015 Accepted February 05, 2016 Published 26, Abstract Gastric cancer...
The coronavirus disease 2019 (COVID-19), the result of an infection with new virus, SARS-CoV-2, is rapidly spreading worldwide. It largely unknown whether occurrence COVID-19 in patients rheumatic immune diseases has some specific manifestations, or makes them more prone to progress into severe COVID-19. In this case report, we describe clinical features 5 concomitant presence Amongst these patients, 4 had rheumatoid arthritis (RA) and 1 systemic sclerosis (SSc). Two a history close contact...
Abstract Radiation colitis is one of the most common complications in patients undergoing pelvic radiotherapy and there no effective treatment clinic. Therefore, searching for agents radiation urgently needed. Herein, it found that essential element selenium (Se) protective against through inhibiting X‐ray‐induced apoptosis, cell cycle arrest, inflammation with involvement balancing generation reactive oxygen species after irradiation. Mechanistically, Se, especially nanoparticles (SeNPs),...
The effects of chilling (CT, day/night temperatures 12/10 °C, an irradiance 250 μmol m-2 s-1), combined with a low (CL, 80 and high temperature (HT, 42/40 s-1) on chlorophyll content, fluorescence, gas exchange were studied in two watermelon cultivars, ZJ8424 YS01, differing their resistance. net photosynthetic rate (PN), stomatal conductance (gs), transpiration (E) decreased substantially, whereas the intercellular CO2 concentration (ci) increased when cultivars grown under these stresses....
MnO<sub>x</sub>–CNT nanocomposites are efficient towards ozone decomposition owing to the electron transfer from CNTs MnO<sub>x</sub> that facilitates activation of ozone.
Abstract Sea buckthorn, a traditional medicinal plant, has been used for several years in China the prevention and treatment of various diseases, practice closely associated with its significant antioxidant activity. The aim this study was to investigate protective effects sea buckthorn flavonoids on vascular endothelial cells an oxidative stress environment. We isolated extracted active compounds from investigated their impact nitric oxide synthase (eNOS) activity through PI3K/AKT‐eNOS...
Abstract Autoreactive B cells are silenced through receptor editing, clonal deletion and anergy induction. Additional autoreactive ignorant because of physical segregation from their cognate autoantigen. Unexpectedly, we find that follicular cell-derived autoantigen, including cell surface molecules such as FcγRIIB, is a class homeostatic autoantigen can induce spontaneous germinal centers (GCs) cell-reactive autoantibodies in non-autoimmune animals with intact T repertoires. These form GCs...
China’s Yunnan Province, known for its tea plantations, faces significant challenges in smart pest management due to ecologically intricate environment. To enable the intelligent monitoring of pests within this study introduces a novel image recognition algorithm, designated as YOLOv8n-WSE-pest. Taking into account data collected from organic gardens Yunnan, utilizes YOLOv8n network foundation and optimizes original loss function using WIoU-v3 achieve dynamic gradient allocation improve...
Previously, serum miR-188-5p is differentially expressed in breast cancer, but the diagnostic potential of circulating as well its regulatory mechanism cancer remain uncertain. Herein, was detected by real-time polymerase chain reaction patients with fibroadenoma, and healthy subjects. Circulating abnormally elevated compared these other two groups, reduced following surgical treatment. Increased corresponded to lymph node metastasis status TNM stages cancer. A receiver operating...
The transcription factor Bach2 is a susceptible gene for numerous autoimmune diseases including systemic lupus erythematosus. Bach2-/- mice can develop lupus-like disease. However, the exact cellular and molecular mechanisms via which protects hosts from developing autoimmunity remains incompletely understood. Here, we report that ablation on T cells, but not B resulted in humoral autoimmunity, this was associated with expansion of follicular helper (Tfh) cells abnormal germinal centers....
The thioredoxin system, which is composed of NADPH, reductase (TrxR), and (Trx), one the major disulfide systems used by bacteria against oxidative stress. In particular, this system crucial for survival pathogenic bacterium Staphylococcus aureus, lacks a natural glutathione/glutaredoxin (Grx) system. Although silver ions silver-containing materials have been as antibacterial agents centuries, mechanism not well-understood. Herein, we demonstrate that bind to active sites S. aureus TrxR Trx...