A5056624509- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Advanced Drug Delivery Systems
- Hydrogels: synthesis, properties, applications
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Advanced Polymer Synthesis and Characterization
- Photodynamic Therapy Research Studies
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- CAR-T cell therapy research
- Wound Healing and Treatments
- Immune Cell Function and Interaction
- Polymer composites and self-healing
- Knee injuries and reconstruction techniques
- Erythropoietin and Anemia Treatment
- Electrospun Nanofibers in Biomedical Applications
- Nanocomposite Films for Food Packaging
- Proteoglycans and glycosaminoglycans research
- Tissue Engineering and Regenerative Medicine
- Dendrimers and Hyperbranched Polymers
- Luminescence and Fluorescent Materials
- Pressure Ulcer Prevention and Management
- Ocular Surface and Contact Lens
- Pain Mechanisms and Treatments
Cancer Institute (WIA)
2025
Tisch Cancer Institute
2025
Icahn School of Medicine at Mount Sinai
2024-2025
Allen Institute for Brain Science
2024-2025
Tisch Hospital
2024
Fudan University
2020-2023
Shanghai Stomatological Hospital
2022
Shanghai University of Traditional Chinese Medicine
2020
China Pharmaceutical University
2018-2019
State Key Laboratory of Natural Medicine
2018
Abstract Reactive nitrogen species (RNS) generated via the reaction of nitric oxide (NO) with reactive oxygen (ROS) are more lethal than ROS, and thus RNS‐mediated therapy has great potential in cancer treatment, yet it is still largely unexploited. Herein, a novel, injectable NO‐releasing hydrogel (NO‐Gel) composed α‐(nitrate ester) acetic acid‐modified amphiphilic copolymers developed. To further convert released NO to RNS, glutathione (GSH)‐sensitive CuCys nanoparticles (NPs) β‐lapachone...
The aim of this research is to utilize a hybrid system liposomal doxorubicin (DOX-Lip) loaded thermogel (DOX-Lip-Gel) realize the steady sustained delivery (DOX), small hydrophilic drug, for treatment breast cancer locally. Herein, was prepared via traditional film dispersion method with particle size 75 nm and drug entrapment efficiency 86%. And, triblock copolymer poly (D, L-lactide-co-glycolide)-b-poly (ethylene glycol)-b-poly L-lactide -co-glycolide) (PLGA-PEG-PLGA) synthesized...
Abstract Aqueous solutions of some amphiphilic block copolymers undergo a sol–gel transition upon heating and are thus called thermogels. In the thermogel family, systems also exhibit gel–sol (suspension) at higher temperatures following transition, which is usually ignored in biomedical applications. Herein, for first time, case reported employing both found development transdermal hydrogel formulation containing 5‐aminolevulinic acid photodynamic therapy (PDT) skin disease. Two poly( d , l...
Abstract Degradability of biomaterials brings many opportunities as well great challenges to their clinical applications. However, reports systematic in vivo biodegradation are rather limited due lack adequate methodology for real‐time observations. Herein, a tri‐modal bioimaging technique is developed, enabling real time monitoring synthetic polymers vivo. The demonstrated material successful preclinical poly(lactic acid‐ co ‐glycolic acid)‐ b ‐poly(ethylene glycol)‐ ‐poly(lactic acid)...
Abstract Traditional skin care masks usually use a piece of paper to hold the aqueous essences, which are not environmentally friendly and easy use. While paper‐free mask is desired, it faced with dilemma moisture holding rapid release encapsulated bioactive substances. Herein, sprayable designed from an intelligent material—a thermogel undergoes sol–gel‐suspension transitions upon heating—to solve this dilemma. A synthesized block copolymer poly(ethylene glycol) poly(lactide‐ co ‐glycolide)...
Abstract Although surgical resection is currently the first choice of clinical treatment for most solid tumors, postoperative cancer recurrence and metastasis are main causes mortality. Herein, authors aim to enable immunotherapy consistent with surgery. To this end, term “therapeutic‐prophylactic vaccine (TPV)” suggested, a TPV‐gel developed as filler after ≈90% tumor eradicate residue (therapeutic) prevent (prophylactic). The made matrix blends two poly( d,l ‐lactide‐ co ‐glycolide)‐ b...
Current treatment options for diabetic wounds face challenges due to low efficacy, as well potential side effects and the necessity repetitive treatments. To address these issues, we report a formulation utilizing trisulfide-derived lipid nanoparticle (TS LNP)-mRNA therapy accelerate wound healing by repairing reprogramming microenvironment of wounds. A library reactive oxygen species (ROS)-responsive TS LNPs was designed developed encapsulate interleukin-4 (IL4) mRNA. TS2-IL4 LNP-mRNA...
Magnetic resonance imaging (MRI) is a promising non-invasive method to assess cartilage regeneration based on the quantitative relationship between MRI features and concentrations of major components in extracellular matrix (ECM). To this end, vitro experiments are performed investigate reveal underlying mechanism. A series collagen (COL) glycosaminoglycan (GAG) solutions at different prepared, T1 T2 relaxation times measured with or without contrast agent (Gd-DTPA2-) by MRI. Fourier...
Local anesthetics are important for the treatment of postoperative pain. Since a single injection solution drug such as bupivacaine (BUP) works only few hours, it is much required to develop long-term injectable formulation that maintains its efficacy more than 1 day. Herein, an intelligent copolymer hydrogel loaded with BUP microcrystals was invented. The biodegradable block synthesized by us and composed central hydrophilic poly(ethylene glycol) (PEG) two hydrophobic...
Abstract Corrodible metals are the newest kind of biodegradable materials and raise a new problem corrosion products. However, removal precipitated products has been unclear even largely ignored in publications. Herein, we find that albumin, an abundant macromolecule serum, enhances solubility iron blood mimetic Hank’s solution significantly. This is universal for other main such as magnesium, zinc polyester-coated iron. Albumin also influences rates diverse trends normal saline. Based on...
Delivery of mRNA (mRNA) to the central nervous system (CNS) remains a significant challenge. Herein, we design library furan-derived lipids and, our knowledge, for first time, leverage meningeal lymphatic vessels (MLVs) route achieve efficient delivery brain. These were engineered with different furan cores, functional groups, and tails. We found that tetrahydrofuran (THF)-derived lipid nanoparticles (LNPs) generally displayed exceptional compared their furan-based counterparts....
Lipid nanoparticle (LNP)-mRNA vaccines have demonstrated protective capability in combating SARS-CoV-2. Their extensive deployment across the global population leads to broad presence of T-cell immunity against SARS-CoV-2 spike protein, presenting an opportunity harness this immunological response as a universal antigen target for cancer treatment. Herein, we design and synthesize series amino alcohol- or acid-derived ionizable lipids (AA lipids) develop LNP-RNA-based presentation platform...
Abstract Lipid nanoparticle‐messenger RNA formulations have garnered significant attention for their therapeutic potential in infectious diseases, cancer and genetic disorders. However, effective mRNA delivery to the central nervous system (CNS) remains a formidable challenge. To overcome this limitation, class of brain‐targeting lipids (BLs) is developed by incorporating small molecules with amino formulated them helper generate lipid nanoparticles (BLNPs) delivery. Screening studies led...
Vulvovaginal candidiasis (VVC) is a typical kind of vaginal mucosal infection. Herein, we developed novel delivery system amphotericin B (AmB) nanosuspension-loaded thermogel (AmB NPs/thermogel) utilising pharmaceutical technique high-pressure homogenisation and Poloxamer P407/P188 hydrogel. The stabiliser hydrogel materials the formulation were tested to maintain proper sol–gel transition as well relative stability particle size AmB nanosuspension in thermogel. nanosuspensions was ∼247 nm....
Tumor metastasis has become a major obstacle for the clinical treatment of malignant breast cancer. Thus, delivery system capable both antitumor and anti-metastasis efficacy is desired. In this work, low molecular weight heparin (LMWH)-based reduction-sensitive was developed, aiming to combine properties drug active excipients achieve synergistic anti-metastatic efficiency as well resolving potential adverse effects doxorubicin LMWH. That is, DOX could be enhanced its toxicity lowered....
Organic polymers with condensed long chains show slow dissolution kinetics in solvents, particularly water, which has significantly hindered their potential applications where instant without any assistance of a stirring machine, etc. is required. Herein, we put forward strategy rapid chain-like by coordinating small molecular additives, using thermogellable amphiphilic copolymer and CaCl2 for demonstration. We synthesized block poly(ethylene glycol) (PEG) poly(lactide-co-glycolide) (PLGA)...
Injectable Hydrogels In article number 2206554, Lin Yu and co-workers develop an injectable thermosensitive hydrogel with inherent long-acting NO-releasing capacity. The system loaded β-lapachone CuCys nanoparticles can synchronously boost intracellular reactive oxygen species nitrogen levels, thereby synergistically enhancing the anti-tumor efficacy. This is suitable as a platform for extending NO-associated medical applications.