A5009926970- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Obsessive-Compulsive Spectrum Disorders
- Genetic Neurodegenerative Diseases
- Pain Management and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Glycogen Storage Diseases and Myoclonus
- Neuroscience and Neural Engineering
- Bioinformatics and Genomic Networks
- RNA regulation and disease
- Vagus Nerve Stimulation Research
- Musculoskeletal pain and rehabilitation
- Neurology and Historical Studies
- Epigenetics and DNA Methylation
- Migraine and Headache Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
- Electroconvulsive Therapy Studies
- Radiomics and Machine Learning in Medical Imaging
- Restless Legs Syndrome Research
- RNA Research and Splicing
Icahn School of Medicine at Mount Sinai
2016-2025
Mount Sinai Health System
2016-2025
Circuit Therapeutics (United States)
2020-2024
New York Proton Center
2024
Mount Sinai Hospital
2016-2021
Mount Sinai Beth Israel
2015-2021
Neurology, Inc
2020
Mount Sinai Medical Center
2014-2019
Cornell University
2018
The Mount
2018
Abstract Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) can provide long-term symptom relief for treatment-resistant depression (TRD) 1 . However, achieving stable recovery is unpredictable 2 , typically requiring trial-and-error adjustments due to individual trajectories and subjective reporting 3 We currently lack objective brain-based biomarkers guide clinical decisions by distinguishing natural transient mood fluctuations from situations intervention. To address this...
Although technological advances have reduced device-related complications, DBS surgery still carries a significant risk of transient and permanent complications. We report our experience in 86 patients 149 implants. Patients with Parkinson's disease, essential tremor dystonia were treated. There 8 perioperative, postoperative, 9 hardware-related complications 4 stimulation-induced side effects. Only 5 (6%) sustained some persistent neurological sequelae, however, 26 the undergoing implants...
Deep brain stimulation (DBS) is a widely accepted therapy for medically refractory Parkinson's disease (PD). Both globus pallidus internus (GPi) and subthalamic nucleus (STN) are safe effective in improving the symptoms of PD reducing dyskinesias. STN DBS most commonly performed surgery as compared to GPi DBS. Ventral intermediate (Vim) infrequently used an alternative tremor predominant patients. Patient selection critical achieving good outcomes. Differential diagnosis should be emphasized...
Numerous factors need to be taken into account when implanting deep brain stimulation (DBS) systems patients with Parkinson's disease. The surgical procedure itself can divided immediate preoperative, intraoperative, and postoperative phases. Preoperative considerations include medication withdrawal issues, stereotactic equipment choices, imaging modalities, targeting strategy. Intraoperative focus on methods for physiological confirmation of a given target DBS electrode deployment. Terms...
Summary A goal of medical research is to determine the molecular basis human brain health and illness. One way achieve this through observational studies gene expression in tissue. Due unavailability tissue from living people, most such are performed using postmortem donors. An assumption underlying practice that an accurate representation brain. Here, – which, until now, had not been adequately tested by comparing prefrontal cortex between 275 samples 243 samples. Expression levels differed...
Objective Refractory psychiatric disease is a major cause of morbidity and mortality worldwide, there great need for new treatments. In the last decade, investigators piloted novel deep brain stimulation (DBS)-based therapies depression obsessive–compulsive disorder (OCD). Results from recent pivotal trials these therapies, however, did not demonstrate degree efficacy expected previous smaller trials. To discuss next steps, neurosurgeons, neurologists, psychiatrists representatives industry...
Abstract Spinal cord stimulation (SCS) is an interventional nonpharmacologic treatment used for chronic pain and other indications. Methods evaluating the safety efficacy of SCS have evolved from uncontrolled retrospective studies to prospective randomized controlled trials (RCTs). Although randomization overcomes certain types bias, additional challenges validity RCTs include blinding, choice control groups, nonspecific effects variables (eg, paresthesia, device programming recharging,...
Parkinson's disease (PD) is genetically associated with the H1 haplotype of MAPT 17q.21.31 locus, although causal gene and variants underlying this association have not been identified.To better understand genetic contribution region to PD identify novel mechanisms conferring risk for disease, we fine-mapped 17q21.31 locus by constructing discrete blocks from data. We used digital PCR assess copy number variation PD-associated blocks, human brain postmortem RNA-seq data candidate genes that...
Dopamine and serotonin are hypothesized to guide social behaviours. In humans, however, we have not yet been able study neuromodulator dynamics as interaction unfolds. Here, obtained subsecond estimates of dopamine from human substantia nigra pars reticulata during the ultimatum game. Participants, who were patients with Parkinson's disease undergoing awake brain surgery, had accept or reject monetary offers varying fairness computer players. They rejected more in than condition, an effect...
Purpose: To prospectively determine the pattern of functional magnetic resonance (MR) imaging activation at 3 T produced by deep brain stimulation (DBS) subthalamic nucleus (STN) for treatment Parkinson disease and to safety DBS electrode during MR T. Materials Methods: Informed consent was obtained from all subjects participating in study, study protocol approved institutional review board Cleveland Clinic Foundation HIPAA compliant. After extensive phantom testing lead systems, five...
A significant number of patients with major depressive disorder are unresponsive to conventional therapies. For these patients, neuromodulation approaches being investigated.To determine whether epidural cortical stimulation at the left dorsolateral prefrontal cortex is safe and efficacious for through a safety feasibility study.Twelve were recruited in this randomized, single-blind, sham-controlled study 104-week follow-up period. The main outcome measures Hamilton Depression Rating...
Central to surgical management of movement disorders is an understanding the anatomy and physiology basal ganglia. The ganglia have been a target for neuromodulation surgery since Russell Meyers' pioneering works in late 1930s. With development deep brain stimulation as gold standard intervention disorders, there has concomitant evolution role plays genesis normal abnormal motor behaviors. fundamental concept cortico-striato-pallido-thalamocortical loop will be explored context stimulation....
Objectives: To investigate the feasibility and safety of an implantable epidural cortical stimulator for treatment severe tinnitus. Study Design: Prospective, controlled, single-blinded study stimulation 4 weeks, then open-label period. Setting: Tertiary care referral center. Patients: Adults (n = 8) with constant tinnitus at least 1 year a reaction questionnaire score greater than 33. Tinnitus was predominantly unilateral frequency less 8,000 Hz. Interventions: Surgical implantation...