A5057135910- Olfactory and Sensory Function Studies
- Advanced Chemical Sensor Technologies
- Sleep and Wakefulness Research
- Biochemical Analysis and Sensing Techniques
- Neurobiology and Insect Physiology Research
- Memory and Neural Mechanisms
- Psychological Well-being and Life Satisfaction
- Mental Health Research Topics
- Experimental Behavioral Economics Studies
- Memory Processes and Influences
- Sleep and related disorders
- COVID-19 and Mental Health
- Neuroendocrine regulation and behavior
- Identity, Memory, and Therapy
- Evolutionary Psychology and Human Behavior
- COVID-19 epidemiological studies
- COVID-19 Digital Contact Tracing
- Human-Animal Interaction Studies
- Obstructive Sleep Apnea Research
- Animal Behavior and Reproduction
- Nicotinic Acetylcholine Receptors Study
- Data-Driven Disease Surveillance
- Evolutionary Game Theory and Cooperation
- Neuroethics, Human Enhancement, Biomedical Innovations
- Hearing Impairment and Communication
Weizmann Institute of Science
2015-2024
Allen Institute for Brain Science
2024
Icahn School of Medicine at Mount Sinai
2020-2024
New York Proton Center
2022
Bar-Ilan University
2019-2020
National Institute of Mental Health
2018
Abstract In response to the coronavirus disease 2019 (COVID-19) pandemic, countries have implemented various strategies reduce and slow spread of in general population. For that restrictions on its population a stepwise manner, monitoring COVID-19 prevalence is importance guide decision when impose new, or abolish old, restrictions. We are here determining whether measures odor intensity large sample can serve as one such measure. Online how intense common household odors perceived symptoms...
Dopamine and serotonin are hypothesized to guide social behaviours. In humans, however, we have not yet been able study neuromodulator dynamics as interaction unfolds. Here, obtained subsecond estimates of dopamine from human substantia nigra pars reticulata during the ultimatum game. Participants, who were patients with Parkinson's disease undergoing awake brain surgery, had accept or reject monetary offers varying fairness computer players. They rejected more in than condition, an effect...
Social chemosignaling is a part of human behavior, but how chemosignals transfer from one individual to another unknown. In turn, humans greet each other with handshakes, the functional antecedents this behavior remain unclear. To ask whether handshakes are used sample conspecific social chemosignals, we covertly filmed 271 subjects within structured greeting event either or without handshake. We found that often sniff their own hands, and selectively increase after After gender, increased...
Most forms of suprathreshold sensory stimulation perturb sleep. In contrast, presentation pure olfactory or mild trigeminal odorants does not lead to behavioral physiological arousal. fact, some odors promote objective and subjective measures sleep quality in humans rodents. The brain mechanisms underlying these sleep-protective properties olfaction remain unclear. Slow oscillations the electroencephalogram (EEG) are a marker deep sleep, K complexes (KCs) an EEG cortical response...
The controllability of our social environment has a profound impact on behavior and mental health. Nevertheless, neurocomputational mechanisms underlying remain elusive. Here, 48 participants performed task where their current choices either did (Controllable), or not (Uncontrollable), influence partners’ future proposals. Computational modeling revealed that people engaged model forward thinking (FT; i.e., calculating the downstream effects actions) to estimate in both Controllable...
Abstract Crises such as the COVID-19 pandemic are known to exacerbate depression and anxiety, though their temporal trajectories remain under-investigated. The present study aims investigate fluctuations in anxiety using a model crisis. A total of 1512 adults living United States enrolled this online beginning April 2, 2020 were assessed weekly for 10 weeks (until June 4, 2020). We measured Zung Self-Rating Depression scale State-Trait Anxiety Inventory (state subscale), respectively, along...
Efficient contact tracing and testing are fundamental tools to contain the transmission of SARS-CoV-2. We used multi-agent simulations estimate daily capacity required find isolate a number infected agents sufficient break chain SARS-CoV-2, so decreasing risk new waves infections. Depending on non-pharmaceutical mitigation policies in place, size secondary infection clusters allowed or percentage asymptomatic paucisymptomatic (i.e., subclinical) infections, we estimated that disease varies...
Key to curtailing the COVID-19 pandemic are wide-scale screening strategies. An ideal screen is one that would not rely on transporting, distributing, and collecting physical specimens. Given olfactory impairment associated with COVID-19, we developed a perceptual measure of olfaction relies smelling household odorants rating them online.
A common goal in olfaction research is modeling the link between odorant structure and odor perception. Such efforts require large data sets on olfactory perception, yet only a few of these are publicly freely available. Given that individual perception may be informative personal makeup interpersonal relationships, we hypothesized people would gladly provide perceptual estimates context an odor-based social network. We developed web-based infrastructure for such network called SmellSpace...
Mammalian olfaction and reproduction are tightly linked, a link less explored in humans. Here, we asked whether human unexplained repeated pregnancy loss (uRPL) is associated with altered olfaction, particularly olfactory responses to body-odor. We found that whereas most women uRPL could identify the body-odor of their spouse, control not. Moreover, rated perceptual attributes men's differently from controls. These pronounced differences were accompanied by an only modest albeit significant...
Whether neurons encode information through their spike rates, activity times or both is an ongoing debate in systems neuroscience. Here, we tested whether humans can discriminate between a pair of temporal odor mixtures (TOMs) composed the same two components delivered rapid succession either one order its reverse. These TOMs presumably activate olfactory but at different and thus differ mainly time neuron activation. We found that most participants could hardly TOMs, although they easily...
ABSTRACT In response to the COVID-19 pandemic, countries have implemented various strategies reduce and slow spread of disease in general population. For that restrictions on its population a step-wise manner, monitoring prevalence is importance guide decision when impose new, or abolish old, restrictions. We are here determining whether measures odor intensity large sample can serve as one such measure. Online how intense common household odors perceived symptoms were collected from 2440...
Abstract We used multi-agent simulations to estimate the testing capacity required find and isolate a number of infections sufficient break chain transmission SARS-CoV-2. Depending on mitigation policies in place, daily between 0.7 3.6 tests per thousand was contain disease. However, if contact tracing efficacy dropped below 60% (e.g. due false negatives or reduced capability), kept growing exponentially, irrespective any capacity. Under these conditions, population’s geographical...
Abstract Introduction Women’s olfactory perception varies across the menstrual cycle. The influence of oral contraceptives on this variability remains unclear. Methods To further estimate this, we assessed discrimination performance for both body odors and ordinary odorants in 36 women, 18 naturally ovulating, using contraceptives. Each participant was tested once a week over course month, data then parsed into phases. Results In ovulating at transition from follicular to luteal phases,...
All primates, including humans, engage in self-face-touching at very high frequency. The functional purpose or antecedents of this behaviour remain unclear. In hybrid review we put forth the hypothesis that subserves self-smelling. We first data implying humans touch their own face then detail evidence from one study implicated an olfactory origin for behaviour: This consists significantly increased nasal inhalation concurrent with self-face-touching, and predictable increases decreases as a...