A5057697108- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Neurotransmitter Receptor Influence on Behavior
- Treatment of Major Depression
- Neural Networks and Applications
- Olfactory and Sensory Function Studies
- Regulation of Appetite and Obesity
- Analytical Chemistry and Sensors
- Speech Recognition and Synthesis
- Healthcare innovation and challenges
- Biochemical Analysis and Sensing Techniques
- Ethics in medical practice
- Alcoholism and Thiamine Deficiency
- Memory and Neural Mechanisms
- Bioinformatics and Genomic Networks
- Advanced Chemical Sensor Technologies
- Speech and Audio Processing
- Electrochemical Analysis and Applications
- Obsessive-Compulsive Spectrum Disorders
- Parkinson's Disease Mechanisms and Treatments
- Tryptophan and brain disorders
Virginia Tech
2013-2025
Biomedical Research Institute
2019-2025
Roanoke College
2024
Significance There is an abundance of circumstantial evidence (primarily work in nonhuman animal models) suggesting that dopamine transients serve as experience-dependent learning signals. This report establishes, to our knowledge, the first direct demonstration subsecond fluctuations concentration human striatum combine two distinct prediction error signals: ( i ) reward term and ii a counterfactual term. These data are surprising because there no prior should superpose actual information...
Recent animal research indicates that dopamine and serotonin, neuromodulators traditionally linked to appetitive aversive processes, are also involved in sensory inference decisions based on such inference. We tested this hypothesis humans by monitoring sub-second striatal serotonin signaling during a visual motion discrimination task separates uncertainty from decision difficulty factorial design. Caudate nucleus recordings (n = 4) revealed multi-scale encoding: three participants, tracked...
Dopamine and serotonin are hypothesized to guide social behaviours. In humans, however, we have not yet been able study neuromodulator dynamics as interaction unfolds. Here, obtained subsecond estimates of dopamine from human substantia nigra pars reticulata during the ultimatum game. Participants, who were patients with Parkinson's disease undergoing awake brain surgery, had accept or reject monetary offers varying fairness computer players. They rejected more in than condition, an effect...
Words represent a uniquely human information channel-humans use words to express thoughts and feelings assign emotional valence experience. Work from model organisms suggests that assignments are carried out in part by the neuromodulators dopamine, serotonin, norepinephrine. Here, we ask whether signaling these extends word semantics humans measuring sub-second neuromodulator dynamics thalamus (N = 13) anterior cingulate cortex 6) of individuals evaluating positive, negative, neutrally...
The noradrenaline (NA) system is one of the brain's major neuromodulatory systems; it originates in a small midbrain nucleus, locus coeruleus (LC), and projects widely throughout brain.
Brain–computer interfaces (BCIs) can convert mental states into signals to drive real-world devices, but it is not known if a given covert task the same when performed with and without BCI-based control. Using BCI likely involves additional cognitive processes, such as multitasking, attention, conflict monitoring. In addition, challenging measure quality of performance. We used whole-brain classifier-based real-time functional MRI address these issues, because method provides both maps...
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The prefrontal cortex (PFC) is a region of the brain that in humans involved production higher-order functions such as cognition, emotion, perception, and behavior. Neurotransmission PFC produces by integrating information from other areas brain. At foundation neurotransmission, extension at functions, are an untold number coordinated molecular processes involving DNA sequence variants genome, RNA transcripts transcriptome, proteins proteome. These "multiomic" foundations poorly understood...
Abstract We introduce a random sensing approach to neurotransmitter detection that provides concurrent, co-localized of dopamine, serotonin, norepinephrine and pH. The generates high quality out-of-sample predictions at 10 milliseconds per estimate. Similar high-quality estimates result when the data are down-sampled suggesting even more dramatic speedups possible. method also works using electrophysiological probes in routine use clinical preparations thus transforming these similar...
Abstract Machine learning advances in electrochemical detection have recently produced sub-second and concurrent of dopamine serotonin during perception action tasks conscious humans. Here, we present a new machine approach to sub-second, separation dopamine, norepinephrine, serotonin. The method exploits low amplitude burst protocol for the controlled voltage waveform demonstrate its efficacy by showing how it separates dopamine-induced signals from norepinephrine induced signals. Previous...
Abstract Background Impulse Control Disorder (ICD) in Parkinson’s disease is a behavioral addiction arising secondary to dopaminergic therapies, most often dopamine receptor agonists. Prior research implicates changes striatal function and heightened activity the dorsal striatum of patients with ICD. However, this prior work does not possess temporal resolution required investigate signaling during real-time progression through various stages decision-making involving anticipation feedback....
Abstract Machine learning advances in electrochemical detection have recently produced subsecond and concurrent of dopamine serotonin during perception action tasks conscious humans. Here, we present a new machine approach to subsecond, separation dopamine, norepinephrine, serotonin. The method exploits low amplitude burst protocol for the controlled voltage waveform demonstrate its efficacy by showing how it separates dopamine-induced signals from norepinephrine induced signals. Previous...