A5053135133- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Lung Cancer Research Studies
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Neurotransmitter Receptor Influence on Behavior
- Neurofibromatosis and Schwannoma Cases
- Lung Cancer Treatments and Mutations
- Neural and Behavioral Psychology Studies
- Neuroscience and Neuropharmacology Research
- Radiomics and Machine Learning in Medical Imaging
- Management of metastatic bone disease
- Trigeminal Neuralgia and Treatments
- Advanced Radiotherapy Techniques
- Neuroscience and Neural Engineering
- Head and Neck Surgical Oncology
- Facial Nerve Paralysis Treatment and Research
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Cancer Genomics and Diagnostics
- Transcranial Magnetic Stimulation Studies
- Epilepsy research and treatment
Wake Forest University
2016-2025
Atrium Health Wake Forest Baptist
2015-2024
Neurological Surgery
2016-2024
Winston-Salem State University
2023-2024
Cleveland Clinic
2022
Wake Forest Baptist Comprehensive Cancer Center
2020
Johns Hopkins Medicine
2020
Johns Hopkins University
2020
Carilion Clinic
2020
Virginia Tech
2020
Abstract Objective Alzheimer disease (AD) is characterized by functional impairment in the neural elements and circuits underlying cognitive memory functions. We hypothesized that fornix/hypothalamus deep brain stimulation (DBS) could modulate neurophysiological activity these pathological possibly produce clinical benefits. Methods conducted a phase I trial 6 patients with mild AD receiving ongoing medication treatment. Patients received continuous for 12 months. Three main lines of...
Abstract Surgical extent‐of‐resection has been shown to have an impact on high‐grade glioma ( HGG ) outcomes; however, complete resection is rarely achievable in difficult‐to‐access DTA tumors. Controlled thermal damage the tumor may same ‐ s. We report our multicenter results of laser interstitial therapy LITT retrospectively reviewed 34 consecutive patients (24 glioblastoma, 10 anaplastic) who underwent at Cleveland Clinic, Washington University, and Wake Forest University (May...
Significance There is an abundance of circumstantial evidence (primarily work in nonhuman animal models) suggesting that dopamine transients serve as experience-dependent learning signals. This report establishes, to our knowledge, the first direct demonstration subsecond fluctuations concentration human striatum combine two distinct prediction error signals: ( i ) reward term and ii a counterfactual term. These data are surprising because there no prior should superpose actual information...
We demonstrate here the first successful implementation in humans of a proof-of-concept system for restoring and improving memory function via facilitation encoding using patient's own hippocampal spatiotemporal neural codes memory. Memory is subject to disruption by drugs, disease brain injury, yet previous attempts restore or rescue typically involved only nonspecific, modulation areas systems related retrieval.We have constructed model processes which hippocampus encodes items firing...
Laser Ablation After Stereotactic Radiosurgery (LAASR) is a multicenter prospective study of laser interstitial thermal (LITT) ablation in patients with radiographic progression after stereotactic radiosurgery for brain metastases.
Laser interstitial thermal therapy (LITT) for mesial temporal lobe epilepsy (mTLE) has reported seizure freedom rates between 36% and 78% with at least 1 year of follow-up. Unfortunately, the lack robust methods capable incorporating inherent variability patient anatomy, ablated volumes, clinical outcomes have limited three-dimensional quantitative analysis surgical targeting its impact on outcomes. We therefore aimed to leverage a novel image-based methodology normalizing therapies across...
The importance of developing unique, neural circuitry-based treatments for the cognitive and neuropsychiatric symptoms Alzheimer disease (AD) was impetus a phase I study deep brain stimulation (DBS) in patients with AD that targeted fornix.To test hypotheses DBS would increase cerebral glucose metabolism cortical hippocampal circuits increased be correlated better clinical outcomes.Open-label trial.Academic medical center.A total 5 mild, probable (1 woman 4 men, mean [SD] age 62.6 [4.2]...
The current drug development pipeline takes approximately fifteen years and $2.6 billion to get a new market. Typically, drugs are tested on two-dimensional (2D) cell cultures animal models estimate their efficacy before reaching human trials. However, these often not representative of the body. 2D culture changes morphology physiology cells, have vastly different anatomy than humans. use bioengineered cell-based organoids may increase probability success during trials by providing...
Recent animal research indicates that dopamine and serotonin, neuromodulators traditionally linked to appetitive aversive processes, are also involved in sensory inference decisions based on such inference. We tested this hypothesis humans by monitoring sub-second striatal serotonin signaling during a visual motion discrimination task separates uncertainty from decision difficulty factorial design. Caudate nucleus recordings (n = 4) revealed multi-scale encoding: three participants, tracked...
OBJECTIVE There are a variety of salvage options available for patients with brain metastases who experience local failure after stereotactic radiosurgery (SRS). These include resection, whole-brain radiation therapy, laser thermoablation, and repeat SRS. is little data on the safety efficacy SRS following prior radiosurgical procedure. This study evaluates clinical outcomes dosimetric characteristics experienced tumor recurrence were subsequently treated METHODS Between 2002 2015, 32 ≥ 1...
We review our single institution experience to determine predictive factors for early and delayed distant brain failure (DBF) after radiosurgery without whole radiotherapy (WBRT) metastases.Between January 2000 December 2010, a total of 464 patients were treated with Gamma Knife stereotactic (SRS) WBRT primary management newly diagnosed metastases. Histology, systemic disease, RPA class, number metastases evaluated as possible predictors DBF rate. rates determined by serial MRI. Kaplan-Meier...
Treatment options for unresectable new and recurrent glioblastoma remain limited. Laser ablation has demonstrated safety as a surgical approach to treating primary brain tumors. The LAANTERN prospective multicenter registry (NCT02392078) data were analyzed determine clinical outcomes patients with IDH wild-type glioblastoma.Demographics, intraprocedural data, adverse events, KPS, health economics, survival prospectively collected then on newly diagnosed who treated laser at 14 US centers...
Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) is a minimally invasive alternative to surgical resection for drug-resistant mesial temporal lobe epilepsy (mTLE). Reported rates of seizure freedom are variable and long-term durability largely unproven. Anterior lobectomy (ATL) remains an option patients with MRgLITT treatment failure. However, the safety efficacy this staged strategy unknown.
Insurers have started to deny reimbursement for routine brain surveillance with magnetic resonance imaging (MRI) after stereotactic radiosurgery (SRS) metastases in favor of symptom-prompted imaging. The authors investigated the clinical and economic impact symptomatic versus asymptomatic related these findings use surveillance.Between January 2000 December 2010, 442 patients underwent upfront SRS metastases. In total, 127 315 were included. Medical records used determine presenting...
Abstract BACKGROUND: Gamma Knife radiosurgery (GKRS) allows for the treatment of intracranial tumors with a high degree dose conformality and precision. There are, however, certain situations wherein GKRS is desired, but single-session contraindicated. In these situations, traditional pin-based head frame cannot be used, because it precludes fractionated treatment. OBJECTIVE: To report our experience in treating patients using relocatable, noninvasive immobilization system. METHODS: Patients...
Abstract Background The effect of immunotherapy on brain metastasis patients remains incompletely understood. Our goal was to evaluate its survival, neurologic death, and patterns failure after stereotactic radiosurgery (SRS) without prior whole-brain radiation therapy (WBRT) in with lung melanoma primaries metastatic the brain. Methods We performed a retrospective analysis 271 consecutive or treated upfront SRS for metastases between 2013 2018. Of these patients, 101 (37%) received 170...
In this study we attempted to discern the factors predictive of neurologic death in patients with brain metastasis treated upfront stereotactic radiosurgery (SRS) without whole radiation therapy (WBRT) while accounting for competing risk nonneurologic death. We performed a retrospective single-institution analysis SRS WBRT. Competing risks was estimate subdistribution hazard ratios (HRs) and predictor variables interest. Of 738 alone, occurred 226 (30.6%), 309 (41.9%). Multivariate...
Organoids, and in particular patient-derived organoids, have emerged as crucial tools for cancer research. Our organoid platform, which has supported tumor organoids (PTOs) from a variety of types, been based on the use hyaluronic acid (HA) collagen, or gelatin, hydrogel bioinks. One hurdle to high throughput PTO biofabrication is that high-throughput multi-well plates, bioprinted volumes increased risk contacting sides wells. When this happens, surface tension causes bioinks fall flat,...