Jian L. Campian
A5034837880- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Cancer Immunotherapy and Biomarkers
- Inflammatory Biomarkers in Disease Prognosis
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Meningioma and schwannoma management
- Radiomics and Machine Learning in Medical Imaging
- Immune Cell Function and Interaction
- Nanoplatforms for cancer theranostics
- Neurofibromatosis and Schwannoma Cases
- MRI in cancer diagnosis
- Immune cells in cancer
- Cancer Treatment and Pharmacology
- Radiopharmaceutical Chemistry and Applications
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- PARP inhibition in cancer therapy
- Advanced Neuroimaging Techniques and Applications
- COVID-19 and healthcare impacts
- Vascular Malformations Diagnosis and Treatment
- Head and Neck Cancer Studies
- Cancer Research and Treatments
- Bone and Joint Diseases
- COVID-19 Clinical Research Studies
Mayo Clinic in Arizona
2022-2025
Washington University in St. Louis
2015-2024
Mayo Clinic
2022-2024
University of Minnesota Rochester
2024
WinnMed
2022-2024
Neurological Surgery
2016-2023
Northwell Health
2009-2020
Hiroshima University
2020
Jewish Hospital
2020
Barnes-Jewish Hospital
2020
Standard therapy for glioblastoma includes surgery, radiotherapy, and temozolomide. This Phase 3 trial evaluates the addition of an autologous tumor lysate-pulsed dendritic cell vaccine (DCVax®-L) to standard newly diagnosed glioblastoma.After surgery chemoradiotherapy, patients were randomized (2:1) receive temozolomide plus DCVax-L (n = 232) or placebo 99). Following recurrence, all allowed DCVax-L, without unblinding. The primary endpoint was progression free survival (PFS); secondary...
The NCCN Guidelines for Central Nervous System (CNS) Cancers focus on management of adult CNS cancers ranging from noninvasive and surgically curable pilocytic astrocytomas to metastatic brain disease. involvement an interdisciplinary team, including neurosurgeons, radiation therapists, oncologists, neurologists, neuroradiologists, is a key factor in the appropriate cancers. Integrated histopathologic molecular characterization tumors such as gliomas should be standard practice. This article...
Glioblastoma is the most lethal primary brain cancer. Clinical outcomes for glioblastoma remain poor, and new treatments are needed.To investigate whether adding autologous tumor lysate-loaded dendritic cell vaccine (DCVax-L) to standard of care (SOC) extends survival among patients with glioblastoma.This phase 3, prospective, externally controlled nonrandomized trial compared overall (OS) in newly diagnosed (nGBM) recurrent (rGBM) treated DCVax-L plus SOC vs contemporaneous matched external...
This study sought to estimate the severity, etiology, and clinical importance of treatment-related lymphopenia in patients with stage III non-small-cell lung cancer.Serial lymphocyte counts survival were analyzed retrospectively 47 accounting for known prognostic factors.Total (TLCs) normal before therapy did not change following neoadjuvant chemotherapy. Following radiation, TLC fell by 67% (median 500 cells/mm(3), p <.00001). Multivariate analysis revealed an association between severe (HR...
Background Poor central nervous system penetration of cytotoxic drugs due to the blood brain barrier (BBB) is a major limiting factor in treatment tumors. Most recurrent glioblastomas (GBM) occur within peritumoral region. In this study, we describe hyperthemic method induce temporary disruption BBB that can potentially be used enhance drug delivery. Methods Twenty patients with probable GBM were enrolled study. Fourteen evaluable. MRI-guided laser interstitial thermal therapy was applied...
<h3>Importance</h3> COVID-19 is a life-threatening illness for many patients. Prior studies have established hematologic cancers as risk factor associated with particularly poor outcomes from COVID-19. To our knowledge, no beneficial role anti–COVID-19 interventions in this at-risk population. Convalescent plasma therapy may benefit immunocompromised individuals COVID-19, including those cancers. <h3>Objective</h3> evaluate the association of convalescent treatment 30-day mortality...
Craniopharyngiomas, primary brain tumors of the pituitary-hypothalamic axis, can cause clinically significant sequelae. Treatment with use surgery, radiation, or both is often associated substantial morbidity related to vision loss, neuroendocrine dysfunction, and memory loss. Genotyping has shown that more than 90% papillary craniopharyngiomas carry
Objectives: Lymphopenia is a common consequence of chemoradiation therapy yet seldom addressed clinically. This study was conducted to determine if patients with locally advanced pancreatic cancer (LAPC) treated definitive develop significant lymphopenia and this affects clinical outcomes. Methods: A retrospective analysis LAPC at single institution from 1997 2011 performed. Total lymphocyte counts (TLCs) were recorded baseline then monthly during after chemoradiation. The correlation...
Severe treatment-related lymphopenia occurs commonly in many cancers and is associated with early tumor progression. Data are lacking as to whether this squamous cell head neck cancer.Serial total lymphocyte counts were retrospectively reviewed patients newly diagnosed cancer undergoing chemoradiation treatment outcomes.The median baseline count 56 was 1660 cells/mm(3) , which fell by 73% 445 2 months after initiating (p < .0001). Human papillomavirus negative (HPV-) a <500 at had...
Bevacizumab treatment at 7.5 mg/kg every 3 weeks results in improved hearing approximately 35%-40% of patients with neurofibromatosis type 2 (NF2) and progressive vestibular schwannomas (VSs). However, the optimal dose is unknown. In this multicenter phase II biomarker study, we evaluated efficacy safety high-dose bevacizumab pediatric adult NF2 VS.Bevacizumab was given for 6 months 10 weeks, followed by 18 5 weeks. The primary end point response defined word recognition score (WRS) months....
<h3>Importance</h3> Non-Hispanic Black individuals experience a higher burden of COVID-19 than the general population; hence, there is an urgent need to characterize unique clinical course and outcomes in patients with cancer. <h3>Objective</h3> To investigate racial disparities severity presentation, complications, between non-Hispanic White cancer COVID-19. <h3>Design, Setting, Participants</h3> This retrospective cohort study used data from Cancer Consortium registry March 17, 2020,...
Patients with glioblastoma (GBM) are treated radiotherapy (RT) and temozolomide (TMZ). These treatments may cause prolonged systemic lymphopenia, which itself is associated poor outcomes. NT-I7 a long-acting IL7 that expands CD4 CD8 T-cell numbers in humans mice. We tested whether prevents lymphopenia improves survival mouse models of GBM.C57BL/6 mice bearing intracranial tumors (GL261 or CT2A) were RT (1.8 Gy/day × 5 days), TMZ (33 mg/kg/day and/or (10 mg/kg on the final day RT). followed...
Treatment options for unresectable new and recurrent glioblastoma remain limited. Laser ablation has demonstrated safety as a surgical approach to treating primary brain tumors. The LAANTERN prospective multicenter registry (NCT02392078) data were analyzed determine clinical outcomes patients with IDH wild-type glioblastoma.Demographics, intraprocedural data, adverse events, KPS, health economics, survival prospectively collected then on newly diagnosed who treated laser at 14 US centers...
Importance Cytokine storm due to COVID-19 can cause high morbidity and mortality may be more common in patients with cancer treated immunotherapy (IO) immune system activation. Objective To determine the association of baseline immunosuppression and/or IO-based therapies severity cytokine cancer. Design, Setting, Participants This registry-based retrospective cohort study included 12 046 reported Cancer Consortium (CCC19) registry from March 2020 May 2022. The CCC19 is a centralized...
Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, characterized by rapid growth, invasive infiltration into surrounding tissue, and resistance to conventional therapies. Despite advancements surgery, radiotherapy, chemotherapy, median survival remains approximately 15 months, underscoring urgent need for innovative treatments. Key considerations informing treatment development include oncogenic genetic epigenetic alterations that may dually serve as therapeutic targets...
Chronic iron overload has slow and insidious effects on heart, liver, other organs. Because iron-driven oxidation of most biologic materials (such as lipids proteins) is readily repaired, this progression organ damage implies some kind biological "memory." We hypothesized that cumulative iron-catalyzed oxidant to mtDNA might occur in overload, perhaps explaining the often lethal cardiac dysfunction. Real time PCR was used examine "intactness" mttDNA cultured H9c2 rat myocytes. After 3-5 days...