A5000423306- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Global Cancer Incidence and Screening
- Lung Cancer Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Neutropenia and Cancer Infections
- Neurological Disease Mechanisms and Treatments
- Multiple Myeloma Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Acute Ischemic Stroke Management
- Cancer, Lipids, and Metabolism
- Cardiac tumors and thrombi
- Cannabis and Cannabinoid Research
- Metastasis and carcinoma case studies
- Heavy Metal Exposure and Toxicity
New York University
2024-2025
University of Minnesota
2019-2024
Sparsh Hospital
2021-2024
University of Minnesota Medical Center
2021-2024
Twin Cities Orthopedics
2023
National University Health System
2016-2019
Dr. Hari Singh Gour University
2019
University Health System
2018
Weatherford College
2018
Orthopedic Specialty Hospital
2018
Small intestine neuroendocrine tumors (SI-NETs) are the most common malignancy of small bowel. Several clinical trials target PI3K/Akt/mTOR signaling; however, it is unknown whether these or other genes genetically altered in tumors. To address underlying genetics, we analyzed 48 SI-NETs by massively parallel exome sequencing. We detected an average 0.1 somatic single nucleotide variants (SNVs) per 106 nucleotides (range, 0-0.59), mostly transitions (C>T and A>G), which suggests that stable...
Importance Cytokine storm due to COVID-19 can cause high morbidity and mortality may be more common in patients with cancer treated immunotherapy (IO) immune system activation. Objective To determine the association of baseline immunosuppression and/or IO-based therapies severity cytokine cancer. Design, Setting, Participants This registry-based retrospective cohort study included 12 046 reported Cancer Consortium (CCC19) registry from March 2020 May 2022. The CCC19 is a centralized...
Importance Patients with stage IV non–small cell lung cancer (NSCLC) experience substantial morbidity and mortality. Contact days (ie, the number of health care contact outside home) measure how much a person’s life is consumed by care, yet little known about patterns for patients NSCLC. Objective To describe trajectories in NSCLC vary receipt cancer-directed treatment routine practice. Design, Setting, Participants A retrospective, population-based decedent cohort study was conducted...
Mutations in Charcot-Marie-Tooth disease (CMT) genes are the cause of rare familial forms polyneuropathy. Whether allelic variability CMT is also associated with common polyneuropathy-considered "acquired" medical parlance-is unknown. Chemotherapy-induced peripheral neuropathy (CIPN) occurs commonly cancer patients and individually unpredictable. We used CIPN as a clinical model to investigate association non-CMT polyneuropathy genes.A total 269 neurologically asymptomatic were enrolled...
Heme oxygenase (HO)-1 degrades heme and protects against oxidative stress, but it has not been pharmacologically induced in humans. In this randomized study of 10 healthy volunteers, hemin (3 mg/kg intravenously 25% albumin) was shown to increase plasma HO-1 protein concentration four- fivefold activity ~15-fold relative baseline at 24 48 h (placebo −56.41 ± 6.31 (baseline), 69.79 13.00 (24 h), 77.44 10.62 (48 h) vs. −71.70 9.20 1,126.20 293.30 1,192.20 333.30 h)) four five subjects as...
<h3>Importance</h3> Androgen deprivation therapy (ADT) has been theorized to decrease the severity of SARS-CoV-2 infection in patients with prostate cancer owing a potential tissue-based expression coreceptor transmembrane protease, serine 2 (TMPRSS2). <h3>Objective</h3> To examine whether ADT is associated decreased rate 30-day mortality from among cancer. <h3>Design, Setting, and Participants</h3> This cohort study analyzed patient data recorded COVID-19 Cancer Consortium registry between...
Background: Fruit and vegetable intake (FVI) among older adults remains below recommended levels for disease prevention. Subjective dietary assessment can be burdensome costly. Reflection spectroscopy (RS) used to non-invasively assess skin carotenoids as a biomarker of fruit but is an underexplored research area adult communities. Objective: To test the hypothesis that VM scores will positively correlated with self-reported carotenoid adults. Design: This secondary analysis data from...
Hospitalized patients with COVID-19 have increased risks of venous (VTE) and arterial thromboembolism (ATE). Active cancer diagnosis treatment are well-known risk factors; however, a assessment model (RAM) for VTE in both is lacking. To assess the incidence factors thrombosis hospitalized COVID-19. Among Cancer Consortium registry (CCC19) cohort study, we assessed ATE within 90 days COVID-19-associated hospitalization. A multivariable logistic regression specifically was built using priori...
Abiraterone and enzalutamide use is associated with significant cardiovascular (CV) morbidity in clinical trials, but the magnitude relevance of this association real-world prostate cancer (PC) population remain unknown.We retrospectively reviewed MarketScan claims databases (1 January 2013 to 30 September 2018) identify adults diagnosis metastatic PC who received treatment androgen deprivation therapy (ADT) novel antiandrogen agents (abiraterone or enzalutamide). The primary CV outcome...
BackgroundIn solid tumours, antibiotic use during immune checkpoint inhibitor (ICI) treatment is associated with shorter survival. Following allogeneic haematopoietic cell transplantation (allo-HCT), antibiotic-induced gut microbiome alterations are risk of relapse and mortality. These findings suggest that the microbiota can modulate antitumour response across tumour types, though it not clear if impact on outcomes specific to therapy. An important limitation previous studies analysis...
Immune checkpoint inhibitors (ICIs) have changed the treatment paradigm of advanced-stage non-small-cell lung cancer (NSCLC) and small-cell (SCLC). The aim this study was to evaluate effectiveness tolerance ICIs in a real-world patient population investigate predictive factors associated with survival outcomes.Medical records patients advanced who started ICI monotherapy were reviewed for data collection. Treatment outcomes included objective response rate, progression-free (PFS), overall...
Abstract Antibiotic exposure during immunotherapy (IO) has been shown to negatively affect clinical outcomes in various cancer types. The aim of this study was evaluate whether antibiotic patients with high-risk early-stage HER2-negative breast (BC) undergoing treatment neoadjuvant pembrolizumab impacted residual burden (RCB) and pathologic complete response (pCR) the pembrolizumab-4 arm ISPY-2 trial. Patients received for four cycles concurrently weekly paclitaxel 12 weeks, followed by...
e20520 Background: Studies have suggested that antibiotics can negatively influence efficacy of immune check-point blockers (ICB) but the results are inconsistent. The impact concomitant proton pump inhibitors (PPI) is not known. We evaluated whether antibiotic and PPI use in patients with advanced non-small-cell lung cancer (NSCLC) metastatic renal cell (RCC) affects ICB efficacy. Methods: identified NSCLC RCC treated anti-PD1/PD-L1 at our institution between 5/2015 to 1/2019. Data...
'Eosinophilia' can occur due to a large number of allergic, infectious, neoplastic, and idiopathic diseases. It range in severity from self-limiting condition life-threatening disorder. The term 'hypereosinophilia' refers eosinophil levels >1500/μL, regardless the underlying cause be associated with tissue organ damage. 'Hypereosinophilic syndrome (HES)' is rare disorder sustained eosinophilia multi-organ dysfunction absence discernable secondary cause. 'Undefined Hypereosinophilic Syndrome'...
Renal transplantation is a well-accepted therapeutic option for patients with end stage renal disease. artery stenosis occurring in transplanted kidney potentially serious condition and adversely affects graft survival prognosis. The objective of this study to document the immediate intermediate term clinical results stenting rare subset stenosis.There limited data about effectiveness transplant stenosis.Eight patients, aged between 22 51 (42.5 ± 9.25) years, were referred our tertiary care...
Infantile hepatic hemangioendothelioma (IHE) is a rare angiogenic tumour with diverse clinical presentations and varied course ranging from spontaneous regression to life-threatening complications. The authors report 2-year boy who presented respiratory distress was identified as case of inoperable multi-focal IHE. He showed transient response trans-arterial-chemo-embolisation liver resection but had progressive disease despite chemotherapy (prednisolone/vicristine/ifosfamide/cisplatin)....