A5078216427- Breast Cancer Treatment Studies
- Acute Myeloid Leukemia Research
- Cancer Risks and Factors
- Venous Thromboembolism Diagnosis and Management
- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- HER2/EGFR in Cancer Research
- Chronic Lymphocytic Leukemia Research
- Alcohol Consumption and Health Effects
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Ovarian cancer diagnosis and treatment
- Neutropenia and Cancer Infections
- Breast Lesions and Carcinomas
- IgG4-Related and Inflammatory Diseases
- Irrigation Practices and Water Management
- Multiple Myeloma Research and Treatments
- Congenital Diaphragmatic Hernia Studies
- Nutritional Studies and Diet
- Methemoglobinemia and Tumor Lysis Syndrome
- Pancreatitis Pathology and Treatment
- Neonatal Health and Biochemistry
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiac tumors and thrombi
Georgetown University
2022-2025
Georgetown University Medical Center
2024-2025
Georgetown Lombardi Comprehensive Cancer Center
2024-2025
MedStar Georgetown University Hospital
2022-2025
Bedford Hospital
2023
University of Baghdad
2022-2023
Thi Qar University
2023
Mustansiriyah University
2022
University of Technology - Iraq
2022
The Ohio State University
2020-2021
This study is aimed at assessing the antihyperglycemic, antihyperlipidemic, and antioxidant effects of Citrus reticulata (C. reticulata) fruit peel hydroethanolic extract two flavonoids, hesperidin quercetin, in nicotinamide (NA)/streptozotocin- (STZ-) induced type 2 diabetic rats. In addition, GC-MS HPLC-MS analyses were performed results indicated presence multiple flavonoids including hesperidin, naringin, polymethoxylated flavones (nobiletin tangeretin). To achieve aim study, rats with...
Primary malignant melanoma of the anus and rectum is a rare aggressive neoplasm that tends to invade locally metastasize early in course disease. It often misdiagnosed as hemorrhoids or one other benign anorectal conditions thus linked an overall poor prognosis 5-year survival rate less than 20%. Optimal treatment still controversial, current evidence does not show any preferential benefit from abdominoperineal resection over wide local excision. Chemotherapy radiotherapy may be used for...
Background: Disease relapse is a primary cause of treatment failure after hematopoietic stem cell transplantation in the malignancy. Consolidation therapy early may reduce this risk, but it difficult to administer setting various post-transplant complications. We proposed that testing donor chimerism and for persistent minimal residual disease (MRD) with next-generation sequencing (NGS) plasma cell-free DNA (cfDNA) would identify those patients at higher risk who possibly benefit from...
Immunotherapy of cancer is now an essential pillar treatment for patients with many individual tumor types. Novel immune targets and technical advances are driving a rapid exploration new strategies incorporating agents in clinical practice. Immunotherapies perturb complex system interactions among genomically unstable cells, diverse cells within the microenvironment including systemic adaptive innate cells. The drive to develop increasingly effective immunotherapy regimens tempered by risk...
Therapeutic Plasma Exchange (TPE) remains a primary therapy for addressing circulating donor-specific antibodies (DSA) against mismatched Human Leukocyte Antigens (HLA), which pose significant challenge to successful transplantation of solid organs and hematopoietic cells. In this study, we evaluated the response five TPE sessions in patients undergoing desensitization, as well who developed antibody-mediated rejection (AMR) post-transplant. Sera collected before after each session was...
Breast cancer relative survival (BCRS), which compares the observed of women with breast expected for whole population same age, time period, and geographical region, tends to be poorer in older women, but reasons this are not clear. We examined influence patient tumour characteristics, treatment on BCRS see whether these could explain age-specific effect. Data 14 048 female patients diagnosed from 1999 2007, aged 50 years or over were obtained Eastern Cancer Registration Information Centre....
Src kinase is elevated in breast tumors that are ER/PR negative and do not overexpress HER2, but clinical trials with inhibitors have shown little activity. The present study evaluated preclinical efficacy of a novel peptidomimetic compound, KX-01 (KX2-391), exhibits dual action as an pretubulin inhibitor. was single-agent combination paclitaxel MDA-MB-231, MDA-MB-157, MDA-MB-468 human ER/PR/HER2-negative cancer cells. Treatments were by growth/apoptosis, isobologram analysis,...
Background Src, a non-receptor tyrosine kinase is elevated in cancer with expression and activity correlated cell proliferation, adhesion, survival, motility, metastasis angiogenesis. There limited data on Src subcellular localization breast no information about racial/ethnic groups. Methodology/Principal Findings The present study evaluated expression, activity, triple negative (TNBC) ERα positive (ER+BC), tissue adjacent normal epithelial ducts, Caucasian African American cases. 79...
BackgroundIn solid tumours, antibiotic use during immune checkpoint inhibitor (ICI) treatment is associated with shorter survival. Following allogeneic haematopoietic cell transplantation (allo-HCT), antibiotic-induced gut microbiome alterations are risk of relapse and mortality. These findings suggest that the microbiota can modulate antitumour response across tumour types, though it not clear if impact on outcomes specific to therapy. An important limitation previous studies analysis...
Primary colorectal lymphoma is a rare malignancy accounting for 3% of all gastrointestinal lymphomas and 0.1-0.5% malignancies. Among primary lymphomas, the most common histological subtype diffuse large B-cell lymphoma. We report case an 84-year old Caucasian female who was admitted to hospital because 2 days history altered mental status. In emergency department patient found have acute kidney injury hypercalcemia. On physical examination lower quadrant abdominal mass palpated. Computed...
Abstract Decitabine has been explored as a reduced‐intensity therapy for older or unfit patients with acute myeloid leukemia (AML). To better understand the risk of infections during decitabine treatment, we retrospectively examined culture results from each infection‐related serious adverse event that occurred among 85 AML and myelodysplastic syndromes ( MDS ) treated in prospective clinical study using 10‐day cycles at Washington University School Medicine. Culture were available 163...
We investigated three common polymorphisms (SNPs) in the XRCC3 gene (rs861539, rs1799794, and rs1799796) 143 Saudi females suffering from breast cancer (median age = 51.4 years) 145 matched normal healthy controls. DNA was extracted whole blood genotyping conducted using PCR-RFLP. rs1799794 showed significant association, where AA AA+AG occurred at a significantly higher frequency patients compared to control group (OR: 28.1; 95% CI: 3.76-21.12; χ (2): 22.82; p < 0.0001). The G allele...
Nanotechnology is receiving greater attention these days as a result of its applications in numerous industrial, medical, and environmental fields.To synthesize silver nanoparticles with green alga, Cladophora glomerata, determine their inhibitory activity against tumor cell (MCF-7) transgenic mouse (L20B) lines.Methanol extract was prepared from glomerata used safe factory for the synthesis (AgNPs). UV-visible spectrophotometer, X-ray diffraction, scanning electron microscopy, EDX analyses...
Obstructive sleep apnea and dyslipidemia are common medical disorders that independently increase vascular morbidity mortality. Current animal human data show that, indeed, obstructive may mediate pathological alterations in cholesterol triglyceride metabolism. The mechanisms involved increased lipolysis, decreased lipoprotein clearance, enhanced lipid output from the liver. Human evidence shows treatment of with continuous positive airway pressure leads to an improvement postprandial...