A5002744671- Statistical Methods in Clinical Trials
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Breast Cancer Treatment Studies
- Pancreatic and Hepatic Oncology Research
- Health Systems, Economic Evaluations, Quality of Life
- Advanced X-ray and CT Imaging
- Advanced Causal Inference Techniques
- Gene expression and cancer classification
- Statistical Methods and Inference
- Advanced Radiotherapy Techniques
- Colorectal Cancer Screening and Detection
- Inflammatory Biomarkers in Disease Prognosis
- Colorectal Cancer Treatments and Studies
- Optimal Experimental Design Methods
- Head and Neck Cancer Studies
- Acute Myeloid Leukemia Research
- AI in cancer detection
The University of Texas at Austin
2020-2025
Regeneron (United States)
2024
Cleveland Clinic Lerner College of Medicine
2019-2023
Brigham and Women's Hospital
2023
The University of Texas MD Anderson Cancer Center
2011-2022
Cleveland Clinic
2018-2021
Colorado School of Public Health
2020
University of Colorado Anschutz Medical Campus
2020
Cancer Institute (WIA)
2019
Cancer Research And Biostatistics
2017
Purpose Placing clips in nodes with biopsy-confirmed metastasis before initiating neoadjuvant therapy allows for evaluation of response breast cancer. Our goal was to determine if pathologic changes clipped reflect the status nodal basin and targeted axillary dissection (TAD), which includes sentinel lymph node (SLND) selective localization removal nodes, improves false-negative rate (FNR) compared SLND alone. Methods A prospective study patients metastases a clip placed sampled performed....
Summary Bayesian clinical trial designs offer the possibility of a substantially reduced sample size, increased statistical power, and reductions in cost ethical hazard. However when prior current information conflict, methods can lead to higher than expected type I error, as well costlier lengthier trial. This motivates an investigation feasibility hierarchical for incorporating historical data that are adaptively robust reveals itself be inconsistent with accumulating experimental data. In...
Delays in time to treatment initiation (TTI) for new cancer diagnoses cause patient distress and may adversely affect outcomes. We investigated trends TTI common solid tumors treated with curative intent, determinants of increased association overall survival.We utilized prospective data from the National Cancer Database newly diagnosed United States patients early-stage breast, prostate, lung, colorectal, renal pancreas cancers 2004-13. was defined as days diagnosis first (surgery, systemic...
Whether dosimetric advantages of proton beam therapy (PBT) translate to improved clinical outcomes compared with intensity-modulated radiation (IMRT) remains unclear. This randomized trial total toxicity burden (TTB) and progression-free survival (PFS) between these modalities for esophageal cancer.This phase IIB randomly assigned patients PBT or IMRT (50.4 Gy), stratified histology, resectability, induction chemotherapy, stage. The prespecified coprimary end points were TTB PFS. TTB, a...
Assessing between-study variability in the context of conventional random-effects meta-analysis is notoriously difficult when incorporating data from only a small number historical studies. In order to borrow strength, and current are often assumed be fully homogeneous, but this can have drastic consequences for power Type I error if information biased. paper, we propose empirical Bayesian modifications commensurate prior model (Hobbs et al., 2011) extending Pocock (1976), evaluate their...
Nodal ultrasonography with needle biopsy of abnormal lymph nodes helps to define the extent breast cancer before neoadjuvant chemotherapy. A clip can be placed designate documented metastases. Targeted axillary dissection or selective removal known contain metastases (clip-containing nodes) as well sentinel (SLNs) may provide more accurate assessment pathologic response after
Objective: To determine the accuracy of fine-needle aspiration (FNA) and vacuum-assisted core biopsy (VACB) in assessing presence residual cancer breast after neoadjuvant systemic therapy (NST). Summary Background Data: Pathologic complete response (pCR) rates NST have improved dramatically, suggesting that surgery might be avoided some patients. Safe avoidance would require accurate confirmation no invasive/in situ carcinoma. Methods: Forty patients with T1-3N0-3 triple-negative or...
With increasing use of immunotherapy agents, pretreatment strategies for identifying responders and non-responders is useful appropriate treatment assignment. We hypothesize that the local immune micro-environment NSCLC associated with patient outcomes these features exhibit distinct radiologic characteristics discernible by quantitative imaging metrics. assembled two cohorts patients treated definitive surgical resection extracted parameters from CT imaging. The excised primary tumors were...
Background Prospective trial design often occurs in the presence of ‘acceptable’ historical control data. Typically, these data are only utilized for treatment comparison a posteriori retrospective analysis to estimate population-averaged effects random-effects meta-analysis. Purpose We propose and investigate an adaptive context actual randomized controlled colorectal cancer trial. This trial, originally reported by Goldberg et al., succeeded similar Saltz used therapy identical that tested...
Abstract Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with variable presentations and natural histories of disease. We hypothesized that different morphologic characteristics PDAC tumors on diagnostic computed tomography (CT) scans would reflect their underlying biology. Experimental Design: developed quantitative method to categorize the morphology pretherapy CT from multiple datasets patients resectable metastatic correlated these patterns clinical/pathologic...
Background Thromboembolism (TE) in cancer significantly contributes to morbidity and mortality. Little is known about the incidence of arterial TE (ATE) venous (VTE) patients with melanoma on immune checkpoint inhibitor (ICI) therapy. Methods We conducted a retrospective cohort study receiving ICI from July 2015 through December 2017 at Cleveland Clinic. TE, including VTE events deep thrombosis, pulmonary embolism, visceral vein ATE myocardial infarction, stroke, peripheral or transient...
Precision medicine endeavors to conform therapeutic interventions the individuals being treated. Implicit concept of precision is heterogeneity treatment benefit among patients and patient subpopulations. Thus, challenges conventional paradigms clinical translational which have relied on estimates population-averaged effects guide practice. Basket trials comprise a class experimental designs used study solid malignancies that are devised evaluate effectiveness strategy defined by presence...
Misgivings have been raised about the operating characteristics of canonical 3+3 dose-escalation phase I clinical trial design. Yet, traditional design is still most commonly used. Although it has implied that adhering to this due a stubborn reluctance adopt change despite other designs performing better in hypothetical computer-generated simulation models, continued adherence strategies more likely because these perform best real world, pinpointing correct dose and important side effects...
Immunotherapy of cancer is now an essential pillar treatment for patients with many individual tumor types. Novel immune targets and technical advances are driving a rapid exploration new strategies incorporating agents in clinical practice. Immunotherapies perturb complex system interactions among genomically unstable cells, diverse cells within the microenvironment including systemic adaptive innate cells. The drive to develop increasingly effective immunotherapy regimens tempered by risk...
To assess whether radiation treatment modality with proton beam therapy (PBT) or intensity-modulated (IMRT) is associated lymphopenia in patients treated definitive chemoradiation for esophageal cancer. Patients cancer bimodality (n = 448) between 2004 and 2016 were retrospectively reviewed. PBT matched by propensity score those IMRT, based on key patient disease factors, stratified clinical stage. who developed early, distant metastatic within 1 month of completing excluded. Univariable...
The process of screening agents one-at-a-time under the current clinical trials system suffers from several deficiencies that could be addressed in order to extend financial and patient resources. In this article, we introduce a statistical framework for designing conducting randomized multi-arm platforms with binary endpoints using Bayesian modeling. essence, proposed platform design consolidates inter-study control arms, enables investigators assign more new patients novel therapies,...