A5043613592- Ovarian cancer diagnosis and treatment
- Cancer Risks and Factors
- Cancer, Lipids, and Metabolism
- BRCA gene mutations in cancer
- Estrogen and related hormone effects
- COVID-19 and healthcare impacts
- Genetic Associations and Epidemiology
- TGF-β signaling in diseases
- Endometrial and Cervical Cancer Treatments
- Nutrition, Genetics, and Disease
- COVID-19 Clinical Research Studies
- Metabolism, Diabetes, and Cancer
- Global Cancer Incidence and Screening
- Protease and Inhibitor Mechanisms
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Breast Cancer Treatment Studies
- Cancer-related molecular mechanisms research
- Blood groups and transfusion
- Nutritional Studies and Diet
- Biomedical Text Mining and Ontologies
- Angiogenesis and VEGF in Cancer
- Economic and Financial Impacts of Cancer
- Inflammatory mediators and NSAID effects
- Erythropoietin and Anemia Treatment
Vanderbilt University Medical Center
2015-2024
Vanderbilt University
2014-2023
Vanderbilt-Ingram Cancer Center
2011-2022
Nashville VA Medical Center
2020
Breast Cancer Research Foundation
2017-2019
Massachusetts Institute of Technology
2018
Boston Children's Hospital
2018
Shanghai Cancer Institute
2011-2013
Army Medical University
2012-2013
Shanghai Municipal Center For Disease Control Prevention
2011-2013
Obesity is a well-established risk factor for endometrial cancer, the most common gynecologic malignancy. Recent genome-wide association studies (GWAS) have identified multiple genetic markers obesity. The authors evaluated of obesity-related single nucleotide polymorphisms (SNPs) with cancer using GWAS data from their recently completed study, Shanghai Endometrial Cancer Genetics Study, which comprised 832 cases and 2,049 controls (1996–2005). Thirty-five SNPs previously associated obesity...
<h3>Importance</h3> Androgen deprivation therapy (ADT) has been theorized to decrease the severity of SARS-CoV-2 infection in patients with prostate cancer owing a potential tissue-based expression coreceptor transmembrane protease, serine 2 (TMPRSS2). <h3>Objective</h3> To examine whether ADT is associated decreased rate 30-day mortality from among cancer. <h3>Design, Setting, and Participants</h3> This cohort study analyzed patient data recorded COVID-19 Cancer Consortium registry between...
High-grade serous ovarian cancer (HGSOC) is the most common and lethal histological subtype of epithelial cancer. HGSOC with cyclin E1 gene (CCNE1) amplification bromodomain extraterminal 4 (BRD4) have been associated poor outcomes. Our objective was to evaluate clinical outcomes co-amplification CCNE1 BRD4 high protein expression E BRD4.
Oral contraceptive use is associated with reduced ovarian cancer risk; however, associations other methods, such as intrauterine device (IUD) and tubal ligation, are less clear. Women in China differ from western women regard to mechanisms duration of contraception. This study was undertaken evaluate between methods risk using data the prospective Shanghai Women's Health Study. Hazard ratios (HRs) 95% confidence intervals (CIs) were estimated by Cox proportional hazards regression. A total...
// Andrew J. Wilson 1 , Oluwole Fadare 2 Alicia Beeghly-Fadiel 3, 4 Deok-Soo Son 5 Qi Liu 6, 7 Shilin Zhao Jeanette Saskowski Md. Jashim Uddin 8, 9 Cristina Daniel Brenda Crews Brian D. Lehmann 4, 8 Jennifer A. Pietenpol Marta Crispens 1, Lawrence Marnett Dineo Khabele Department of Obstetrics & Gynecology, Vanderbilt University Medical Center, Nashville, TN Pathology, California San Diego School Medicine, La Jolla, CA 3 Division Epidemiology, Vanderbilt-Ingram Cancer Biochemistry Biology,...
Ovarian cancer (OC) has the highest mortality rate among gynecological malignancies.Because chemokine network is involved in OC progression, we evaluated associations between expression and survival tumor suppressor protein p53 (TP53) wildtype (TP53WT) mutant (TP53m) datasets.TP53 was highly mutated compared to other types.Among subtypes, CXCL14 predominantly expressed clear cell OC, CCL15 CCL20 mucinous OC.TP53WT endometrioid TP53m, showing better progression-free but no difference overall...
Diagnosed before age 50, early onset pancreatic malignancy (EOPM), is hypothesized to be a distinct subset of disease, although research limited. To better characterize EOPM, and the effect at diagnosis on cancer survival, we examined clinical characteristics survival in EOPM typical age-at-onset (TOPM) cases. Vanderbilt University Medical Center (VUMC) Cancer Registry confirmed adenocarcinomas (PDACs) malignant neuroendocrine tumors (PNETs) were evaluated. Clinical compared using χ(2)...
Tissue inhibitors of metalloproteinases (TIMPs) are endogenous matrix which involved in normal cellular processes and also cancer development progression. The purpose this study was to evaluate polymorphisms the TIMP-2 TIMP-3 genes for their associations with breast susceptibility survival. Using data from Shanghai Breast Cancer Study, 19 SNPs each gene were evaluated risk among 1,062 cases 1,069 controls; disease-free overall survival cases. For TIMP-2, women rs7501477 TT genotype 3 times...
Studies of anthropometric measures and ovarian cancer risk have predominantly included women European descent with mixed findings.Data from the prospective Shanghai Women's Health Study (SWHS) were used to evaluate associations between epithelial (EOC). Hazard ratios (HRs) 95% confidence intervals (CIs) estimated by Cox proportional hazards regression.A total 152 EOC cases occurred among 70 258 women. Increasing quartiles weight, hip circumference, weight gain during adulthood associated...
Patients with B-lymphoid malignancies have been consistently identified as a population at high risk of severe COVID-19. Whether this is exclusively due to cancer-related deficits in humoral and cellular immunity, or whether COVID-19 increased by anticancer therapy, uncertain. Using data derived from the Cancer Consortium (CCC19), we show that patients treated for an compared control populations non-B-lymphoid malignancies. Among malignancies, those who received therapy within 12 months...
Prior studies have demonstrated an association between cutaneous chronic graft-vs-host disease (cGVHD) and mortality. Assessment of the prognostic value different measures severity would assist in risk stratification.
Matrix metalloproteinase-7 (MMP-7) is a small secreted proteolytic enzyme with broad substrate specificity against ECM and non-ECM components. Known to be vital for tumor invasion metastasis, accumulating evidence also implicates MMP-7 in cancer development. Using data from the Shanghai Breast Cancer Study, we conducted two-stage study evaluate association of single nucleotide polymorphisms (SNPs) breast risk. Additionally, associated SNPs were characterized by laboratory assays. In stage 1,...
STUDY QUESTIONDo genetic polymorphisms which influence age at menarche in women of European ancestry also Chinese ancestry?