A5085425812- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Global Cancer Incidence and Screening
- Chromatin Remodeling and Cancer
- Peptidase Inhibition and Analysis
- Colorectal Cancer Screening and Detection
- COVID-19 and Mental Health
- Inflammatory mediators and NSAID effects
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Cancer Risks and Factors
- Helicobacter pylori-related gastroenterology studies
- Multiple and Secondary Primary Cancers
- Sarcoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Colorectal and Anal Carcinomas
- Lung Cancer Diagnosis and Treatment
- Healthcare cost, quality, practices
- Hormonal and reproductive studies
- Autophagy in Disease and Therapy
- COVID-19 diagnosis using AI
- Mobile Health and mHealth Applications
Roswell Park Comprehensive Cancer Center
2024-2025
National Human Genome Research Institute
2019-2024
National Institutes of Health
2019-2024
Terasaki Foundation
2021-2024
Georgetown University
2018-2023
Georgetown University Medical Center
2018-2023
The University of Texas MD Anderson Cancer Center
2014-2022
KIST Medical College
2021
University of California, Los Angeles
2021
National Institute of Health
2020-2021
Abstract Purpose: Colorectal cancers are classified as right/left-sided based on whether they occur before/after the splenic flexure, with established differences in molecular subtypes and outcomes. However, it is unclear if this division optimal precise tumor location provides further information. Experimental Design: In 1,876 patients colorectal cancer, we compared mutation prevalence overall survival (OS) according to side location. Consensus subtype (CMS) was a separate cohort of 608...
Abstract Limited clinical activity has been seen in osteosarcoma (OS) patients treated with immune checkpoint inhibitors (ICI). To gain insights into the immunogenic potential of these tumors, we conducted whole genome, RNA, and T-cell receptor sequencing, immunohistochemistry reverse phase protein array profiling (RPPA) on OS specimens from 48 pediatric adult primary, relapsed, metastatic OS. Median infiltrate level was lower than other tumor types where ICI are effective, concomitant low...
Aspirin and non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) are preventive against cardiovascular disease (CVD) several cancer types, but long-term use has been associated with significant health risks, resulting in conflicting recommendations on NSAID for prevention of CVD cancer. Previous research indicates that aspirin increases age risk factors a large percentage the US population regularly analgesics, including NSAIDs, there not recent, in-depth assessment prevalence, changes...
During the coronavirus disease 2019 (COVID-19) pandemic, gun violence (GV) in United States (U.S.) was postulated to increase strain on already taxed healthcare resources, such as blood products, intensive care beds, personal protective equipment, and even hospital staff. This report aims estimate relative risk of GV U.S. during pandemic compared before pandemic. Daily police reports corresponding gun-related injuries deaths 50 states District Columbia from February 1st, 2019, March 31st,...
SMAD4 is an essential mediator in the transforming growth factor-β pathway. Sporadic mutations of are present 2.1–20.0% colorectal cancers (CRCs) but data limited. In this study, we aimed to evaluate clinicopathologic characteristics, prognosis, and clinical outcome associated with mutation CRC cases. Data for patients metastatic or unresectable who underwent genotyping received treatment at The University Texas MD Anderson Cancer Center from 2000 2014 were reviewed. Their tumors sequenced...
Abstract Purpose: AT-rich interactive domain 1A (ARID1A) is commonly mutated in colorectal cancer, frequently resulting truncation and loss of protein expression. ARID1A recruits MSH2 for mismatch repair during DNA replication. deficiency promotes hypermutability immune activation preclinical models, but its role patients with cancer being explored. Experimental Design: The sequencing gene expression profiling were extracted from Cancer Genome Atlas MD Anderson Center databases, validation...
Breast density is associated with breast cancer risk in women aged 40 to 65 years, but there limited evidence of its association among years or older.To compare the between and invasive 74 vs 75 older evaluate whether modified by body mass index (BMI).This prospective cohort study used data from Cancer Surveillance Consortium January 1, 1996, December 31, 2012, for US who underwent screening mammography. Data were analyzed 2018, 2020.Breast Imaging Reporting System category, age, BMI.The...
// Amir Mehrvarz Sarshekeh 1 , Shailesh Advani Daniel M. Halperin Claudius Conrad 2 Chan Shen 3 James C. Yao and Arvind Dasari Department of Gastrointestinal Medical Oncology, The University Texas MD Anderson Cancer Center, Houston, TX 77030, USA Surgical Health Services Research, Correspondence to: Dasari, email: adasari@mdanderson.org Keywords: appendix, neuroendocrine, right hemicolectomy, survival, tumor size Received: May 09, 2017 Accepted: June 30,...
The mucinous histologic subtype accounts for 5% to 20% of colorectal cancer (CRC) cases but remains poorly characterized. present study characterized the baseline characteristics, mutational profile, and clinical outcomes patients diagnosed with CRC.