A5008335692- Global Cancer Incidence and Screening
- Liver Disease Diagnosis and Treatment
- AI in cancer detection
- Digital Radiography and Breast Imaging
- Breast Cancer Treatment Studies
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Cancer Risks and Factors
- Liver Disease and Transplantation
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Cervical Cancer and HPV Research
- MRI in cancer diagnosis
- Breast Lesions and Carcinomas
- Hepatocellular Carcinoma Treatment and Prognosis
- Head and Neck Cancer Studies
- BRCA gene mutations in cancer
- Medical Imaging Techniques and Applications
- Artificial Intelligence in Healthcare
- COVID-19 and healthcare impacts
- Economic and Financial Impacts of Cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Systems, Economic Evaluations, Quality of Life
- Hepatitis C virus research
- Herpesvirus Infections and Treatments
University of North Carolina at Chapel Hill
2016-2025
Kaiser Permanente Washington Health Research Institute
2013-2025
University of California, Davis
2013-2025
Dartmouth College
2013-2025
University of Vermont
2013-2025
University of Washington
2015-2025
University of North Carolina Health Care
2016-2025
UNC Lineberger Comprehensive Cancer Center
2018-2025
Huntsman Cancer Institute
2025
Fred Hutch Cancer Center
2025
Purpose To establish performance benchmarks for modern screening digital mammography and assess trends over time in U.S. community practice. Materials Methods This HIPAA-compliant, institutional review board–approved study measured the of interpreted by 359 radiologists across 95 facilities six Breast Cancer Surveillance Consortium (BCSC) registries. The included 1 682 504 mammograms performed between 2007 2013 792 808 women. Performance measures were calculated according to American College...
Hepatitis C virus (HCV) infection causes liver cancer and cirrhosis may also increase the risk of other tumors, particularly hematopoietic malignancies thyroid cancer. Previous studies have been too small to adequately assess these risks.To test hypothesis that HCV is associated with increased for hematological malignancies, related lymphoproliferative disorders, cancer.A retrospective cohort study users US Veterans Affairs health care facilities from 1997-2004, which included 146,394...
Hepatitis C virus (HCV) may increase the risk of hepatopancreaticobiliary tumors other than hepatocellular carcinoma (HCC). Previous case control studies indicated a possible association between HCV and intrahepatic cholangiocarcinoma (ICC). Little is known about extrahepatic (ECC) or pancreatic cancer. We conducted cohort study including 146,394 HCV-infected 572,293 HCV-uninfected patients who received care at Veterans Affairs health facilities. Patients with two visits 1996 2004 infection...
This article has been corrected. The original version (PDF) is appended to this as a supplement. Background: Surveillance for hepatocellular carcinoma (HCC) recommended patients with hepatitis C virus (HCV) infection and cirrhosis. However, whether surveillance being done unknown. Objective: To examine the prevalence determinants of HCC among HCV-infected cirrhosis in Veterans Affairs (VA) health care facilities United States. Design: Retrospective cohort study using data obtained from...
Speeding up stomatal responses A plant's cellular metabolism rapidly adjusts to changes in light conditions, but its stomata—pores that allow gas exchange leaves—are slower respond. Because of the lagging response, photosynthesis is less efficient, and excess water lost through open pores. Papanatsiou et al. introduced a blue light–responsive ion channel into stomata small mustard plant Arabidopsis. The increased rate opening closing response light. engineered plants produced more biomass,...
Background: There are well-documented disparities in lung cancer outcomes across populations. Lung screening (LCS) has the potential to reduce mortality, but for this benefit be realized by all high-risk groups, there must careful attention ensuring equitable access lifesaving preventive health measure.Objectives: To outline current knowledge on eligibility criteria for, to, and implementation of LCS, develop an official American Thoracic Society statement propose strategies optimize...
This cross-sectional study compares lung cancer screening prevalence in 2022 among individuals eligible by 2021 vs 2013 criteria sociodemographics and state.
Breast magnetic resonance imaging (MRI) is increasingly used for breast cancer screening, diagnostic evaluation, and surveillance. However, we lack data on national patterns of MRI use in community practice.To describe US practice during the period 2005 through 2009.Observational cohort study using collected from 2009 mammography 5 Cancer Surveillance Consortium registries. Data included 8931 examinations 1,288,924 screening mammograms women aged 18 to 79 years.We calculated rate per 1000...
Significance Insects are among the most robust organisms on planet, surviving in virtually all environments and capable of surmounting a range environmental stresses including desiccation cold. Although cold tolerance share many common traits, potential mechanisms for such linked responses remain unclear. Here we show that an insect neuropeptide gene is associated with both Drosophila melanogaster , suggesting novel mechanism renal tubule epithelia enhances survival Also, can reverse...
Digital mammography (DM) and digital breast tomosynthesis (DBT) are used for routine cancer screening. There is minimal evidence on performance outcomes by age, screening round, density in community practice.To compare DM vs DBT baseline subsequent category.This comparative effectiveness study assessed 1 584 079 examinations of women aged 40 to 79 years without prior history cancer, mastectomy, or augmentation undergoing at 46 participating Breast Cancer Surveillance Consortium facilities...
Abstract The gut of Drosophila melanogaster includes a proximal acidic region (~pH 2), however the genome lacks H + /K ATPase characteristic mammalian gastric parietal cell and molecular mechanisms acid generation are poorly understood. Here, we show that maintenance low pH is dependent on V-ATPase, together with carbonic anhydrase five further transporters or channels mediate K , Cl − HCO 3 transport. Abrogation did not influence larval survival under standard laboratory conditions, but was...
Purpose To establish contemporary performance benchmarks for diagnostic digital mammography with use of recent data from the Breast Cancer Surveillance Consortium (BCSC). Materials and Methods Institutional review board approval was obtained active or passive consenting processes to obtain a waiver consent enroll participants, link data, perform analyses. Data were six BCSC registries (418 radiologists, 92 radiology facilities). Mammogram indication assessments prospectively collected women...
<h3>Importance</h3> Screening mammography intervals remain under debate in the United States. <h3>Objective</h3> To compare proportion of breast cancers with less vs more favorable prognostic characteristics women screening annually biennially by age, menopausal status, and postmenopausal hormone therapy (HT) use. <h3>Design, Setting, Participants</h3> This was a study prospective cohort from 1996 to 2012 at Breast Cancer Surveillance Consortium facilities. A total 15 440 ages 40 85 years...
Whole-breast ultrasonography has been advocated to supplement screening mammography improve outcomes in women with dense breasts.To determine the performance of plus compared alone community practice.Observational cohort study. Two Breast Cancer Surveillance Consortium registries provided prospectively collected data on vs without same-day breast from January 1, 2000, December 31, 2013. The dates analysis were March 2014 2018. A total 6081 examinations 3386 propensity score matched 1:5 30...
To evaluate comparative associations of breast magnetic resonance imaging (MRI) background parenchymal enhancement (BPE) and mammographic density with subsequent cancer risk.
BACKGROUND To understand how health care delays may affect breast cancer detection, the authors quantified changes in breast‐related preventive and diagnostic during coronavirus disease 2019 (COVID‐19) pandemic. METHODS Eligible women (N = 39,444) were aged ≥18 years received a screening mammogram, or biopsy between January 1, September 30, 2020, at 7 academic community imaging facilities North Carolina. Changes number of mammography examinations after March 3, 2020 (the first COVID‐19...
<h3>Importance</h3> For lung cancer screening to confer mortality benefit, adherence annual with low-dose computed tomography scans is essential. Although the National Lung Screening Trial had an rate of 95%, current data are limited on across diverse practice settings in United States. <h3>Objective</h3> To evaluate patterns and factors associated for after negative results a baseline examination, particularly centralized vs decentralized programs. <h3>Design, Setting, Participants</h3>...
Diagnostic delays in breast cancer detection may be associated with later-stage disease and higher anxiety, but data on multilevel factors diagnostic delay are limited.To evaluate individual-, neighborhood-, health care-level differences time from abnormal screening to biopsy among racial ethnic groups.This prospective cohort study used women aged 40 79 years who had results mammograms conducted 109 imaging facilities across 6 US states between 2009 2019. Data were analyzed February 21...
Lung cancer screening with low-dose computed tomography (LDCT) may uncover incidental findings (IFs) unrelated to lung cancer. There be potential benefits from identifying clinically significant IFs that warrant intervention and harms related are not but result in additional evaluation, clinician effort, patient anxiety, complications, excess cost. To identify knowledge research gaps develop prioritize questions address the approach management of IFs. We convened a multidisciplinary panel...
Despite similar on-site availability, differences existed in the distribution of some standard-of-care, advanced, and same-day diagnostic services biopsies for Black White patients after undergoing screening mammography.
Purpose To compare screening magnetic resonance (MR) imaging performance in the Breast Cancer Surveillance Consortium (BCSC) with Imaging Reporting and Data System (BI-RADS) benchmarks. Materials Methods This study was approved by institutional review board compliant HIPAA included BCSC MR examinations collected between 2005 2013 from 5343 women (8387 examinations) linked to regional Surveillance, Epidemiology, End Results program registries, state tumor pathologic information databases that...
BACKGROUND Uptake of breast magnetic resonance imaging (MRI) coupled with cancer risk assessment offers the opportunity to tailor benefits and harms screening strategies for women differing risks. Despite potential benefits, there is also concern worsening population‐based health disparities. METHODS Among 316,172 aged 35 69 years from 5 Breast Cancer Surveillance Consortium registries (2007‐2012), authors examined 617,723 negative mammograms 1047 MRIs. They relative risks (RRs) MRI use by a...