Lori C. Sakoda
A5044332098- Genetic factors in colorectal cancer
- Genetic Associations and Epidemiology
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Screening and Detection
- Global Cancer Incidence and Screening
- Lung Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- BRCA gene mutations in cancer
- Nutrition, Genetics, and Disease
- Nutritional Studies and Diet
- Prostate Cancer Treatment and Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Risks and Factors
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Digestive system and related health
- Economic and Financial Impacts of Cancer
- MicroRNA in disease regulation
- Folate and B Vitamins Research
- Inflammatory mediators and NSAID effects
- Multiple and Secondary Primary Cancers
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
Kaiser Permanente
2016-2025
Fred Hutch Cancer Center
2012-2024
Cancer Research Center
2020-2023
Binus University
2023
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2023
Harvard University
2021-2023
Canadian Respiratory Research Network
2023
Kaiser Permanente Tysons Corner Medical Center
2023
Seattle University
2013-2022
University of California, Los Angeles
2022
One type of fecal occult blood test (FOBT), the unrehydrated guaiac (GT), is recommended by United States Preventive Services Task Force and Institute Medicine for use in screening programs, but it has relatively low sensitivity as a single detecting advanced colonic neoplasms (cancer adenomatous polyps > or = 1 cm diameter). Thus, improving FOBT should make colon cancer programs that these tests more effective.We assessed prospectively performance characteristics two newer FOBTs 5841...
Abstract Using genome-wide genotypes, we characterized the genetic structure of 103,006 participants in Kaiser Permanente Northern California multi-ethnic Genetic Epidemiology Research on Adult Health and Aging Cohort analyzed relationship to self-reported race/ethnicity. Participants endorsed any 23 race/ethnicity/nationality categories, which were collapsed into seven major race/ethnicity groups. By self-report cohort is 80.8% white 19.2% minority; 93.8% a single group, while 6.2% two or...
Deciphering the shared genetic basis of distinct cancers has potential to elucidate carcinogenic mechanisms and inform broadly applicable risk assessment efforts. Here, we undertake genome-wide association studies (GWAS) comprehensive evaluations heritability pleiotropy across 18 cancer types in two large, population-based cohorts: UK Biobank (408,786 European ancestry individuals; 48,961 cases) Kaiser Permanente Genetic Epidemiology Research on Adult Health Aging cohorts (66,526 16,001...
Abstract The Kaiser Permanente (KP) Research Program on Genes, Environment and Health (RPGEH), in collaboration with the University of California—San Francisco, undertook genome-wide genotyping >100,000 subjects that constitute Genetic Epidemiology Adult Aging (GERA) cohort. project, which generated >70 billion genotypes, represents first large-scale use Affymetrix Axiom Genotyping Solution. Because took place over a short 14-month period, creating near-real-time analysis...
Background: There are well-documented disparities in lung cancer outcomes across populations. Lung screening (LCS) has the potential to reduce mortality, but for this benefit be realized by all high-risk groups, there must careful attention ensuring equitable access lifesaving preventive health measure.Objectives: To outline current knowledge on eligibility criteria for, to, and implementation of LCS, develop an official American Thoracic Society statement propose strategies optimize...
We conducted a population-based study of 627 patients with biliary tract cancers (368 gallbladder, 191 bile duct, and 68 ampulla Vater), 1037 stones, 959 healthy controls randomly selected from the Shanghai population, all personally interviewed. Gallstone status was based on information self-reports, imaging procedures, surgical notes, medical records. Among controls, transabdominal ultrasound performed to detect asymptomatic gallstones. Gallstones removed cancer cases gallstone were...
Abstract Recently, the incidence of intrahepatic cholangiocarcinoma (ICC) has been increasing in a number developed (Western) countries. However, risk factors these low‐risk populations are poorly understood. In this nationwide population based case‐control study Denmark, we examined relationship between selected medical conditions and subsequent ICC to provide additional clues etiopathogenesis. All histologically confirmed cases diagnosed Denmark 1978 1991 were identified from Danish cancer...
A genome-wide association study (GWAS) of prostate cancer in Kaiser Permanente health plan members (7,783 cases, 38,595 controls; 80.3% non-Hispanic white, 4.9% African-American, 7.0% East Asian, and 7.8% Latino) revealed a new independent risk indel rs4646284 at the previously identified locus 6q25.3 that replicated PEGASUS (N = 7,539) Multiethnic Cohort 4,679) with an overall P 1.0 × 10(-19) (OR, 1.18). Across locus, exhibited strongest expression SLC22A1 (P 1.3 10(-23)) SLC22A3 3.2...
The Kaiser Permanente Research Program on Genes, Environment, and Health (RPGEH) Genetic Epidemiology Adult Aging (GERA) cohort includes DNA specimens extracted from saliva samples of 110,266 individuals. Because its relationship to aging, telomere length measurement was considered an important biomarker develop these subjects. To assay relative (TL) this large over a short time period, we created novel high throughput robotic system for TL analysis informatics. Samples were run in...
Abstract Background Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub-site or sex is unclear. Further, metabolic alterations mediating effects on CRC are not fully understood. Methods We examined sex- and site-specific associations with adiposity-associated metabolites explain CRC. Genetic variants from genome-wide association studies body mass index (BMI) waist-to-hip ratio (WHR, unadjusted for BMI; N = 806,810), 123...
Background & AimsHuman studies examining associations between circulating levels of insulin-like growth factor 1 (IGF1) and binding protein 3 (IGFBP3) colorectal cancer risk have reported inconsistent results. We conducted complementary serologic Mendelian randomization (MR) analyses to determine whether alterations in IGF1 or IGFBP3 are associated with development.MethodsSerum were measured blood samples collected from 397,380 participants the UK Biobank, 2006 through 2010. Incident cases...
PURPOSE This pilot study examined the ability to operationalize collection of real-world data explore potential use end points extracted from diverse health care organizations and assess how these relate similar in clinical trials for immunotherapy-treated advanced non–small-cell lung cancer. PATIENTS AND METHODS Researchers six followed a common protocol using administrative claims electronic records points, including overall survival (rwOS), time next treatment, treatment discontinuation...
The PI3K/AKT-signaling pathway is one of the most frequently activated signal-transduction pathways in cancer. We examined how dysregulated gene expression associated with miRNA this colorectal cancer (CRC). used data from 217 CRC cases to evaluate differential between paired carcinoma and normal mucosa identify miRNAs that are these genes. Gene RNA-Seq Agilent Human Microarray V19.0 were analyzed. focused on genes (fold change (FC) >1.5 or <0.67) statistically significant after adjustment...
Apoptosis is genetically regulated and involves intrinsic extrinsic pathways. We examined 133 genes within these pathways to identify whether they are expressed differently in colorectal carcinoma (CRC) normal tissue (N = 217) if associated with similar differential miRNA expression. Gene expression data (RNA-Seq) (Agilent Human Microarray V19.0) were generated. focused on dysregulated a fold change (FC) of > 1.50 or < 0.67, that significant after adjustment for multiple comparisons....
<h3>Importance</h3> For lung cancer screening to confer mortality benefit, adherence annual with low-dose computed tomography scans is essential. Although the National Lung Screening Trial had an rate of 95%, current data are limited on across diverse practice settings in United States. <h3>Objective</h3> To evaluate patterns and factors associated for after negative results a baseline examination, particularly centralized vs decentralized programs. <h3>Design, Setting, Participants</h3>...
Abstract Background Incidence of early-onset (younger than 50 years age) colorectal cancer (CRC) is increasing in many countries. Thus, elucidating the role traditional CRC risk factors a high priority. We sought to determine whether associated with late-onset were also linked and association patterns differed by anatomic subsite. Methods Using data pooled from 13 population-based studies, we studied 3767 cases 4049 controls aged younger 23 437 35 311 older. multivariable multinomial...
The incidence of colorectal cancer (CRC) among individuals aged younger than 50 years has been increasing. As screening guidelines lower the recommended age initiation, concerns including burden on capacity and costs have recognized, suggesting that an individualized approach may be warranted. We developed risk prediction models for early-onset CRC incorporate environmental score (ERS), 16 lifestyle factors, a polygenic (PRS) 141 variants.
Abstract Objective: Although endometriosis and uterine leiomyomas are common conditions, the extent to which either is associated with certain types of malignancies remains uncertain. Methods: Using record linkage techniques, we assessed relationships between hospital outpatient admissions for or development ovarian cancers in Denmark 1978 1998. Based on a population-based cohort exceeding 99,000 women, including 2,491 cancers, 860 borderline tumors, 1,398 derived relative risks (RR) 95%...