A5035070420- Genetic Associations and Epidemiology
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- American Constitutional Law and Politics
- Genetic Mapping and Diversity in Plants and Animals
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Bioinformatics and Genomic Networks
- Epigenetics and DNA Methylation
- Genetic and phenotypic traits in livestock
- Genomics and Rare Diseases
- Genomic variations and chromosomal abnormalities
- Nutrition, Genetics, and Disease
- Cancer-related molecular mechanisms research
- Gene expression and cancer classification
- Molecular Biology Techniques and Applications
- Cancer, Lipids, and Metabolism
- Glutathione Transferases and Polymorphisms
- Folate and B Vitamins Research
- Nutritional Studies and Diet
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Colorectal Cancer Screening and Detection
- Estrogen and related hormone effects
- Reformation and Early Modern Christianity
Stanford University
2016-2025
Kaiser Permanente
2025
Stanford Health Care
2025
Pediatrics and Genetics
2021-2025
Regeneron (United States)
2024
University of California, San Francisco
2014-2023
Emory University
2006-2023
UCSF Helen Diller Family Comprehensive Cancer Center
2013-2023
Stanford Medicine
2022-2023
Stanford Cancer Institute
2023
Chromosome substitution strains (CSSs) have been proposed as a simple and powerful way to identify quantitative trait loci (QTLs) affecting developmental, physiological, behavioral processes. Here, we report the construction of complete CSS panel for vertebrate species. The consists 22 mouse strains, each which carries single chromosome substituted from donor strain (A/J) onto common host background (C57BL/6J). A survey 53 traits revealed evidence 150 QTLs serum levels sterols amino acids,...
Prostate cancer (CaP) is the leading among men of African descent in USA, Caribbean, and Sub-Saharan Africa (SSA). The estimated number CaP deaths SSA during 2008 was more than five times that Americans expected to double by 2030. We summarize publicly available data collected from Carcinoma (MADCaP) Consortium Caribbean Cancer (AC3) evaluate incidence mortality worldwide. are highest USA Caribbean. Tumor stage grade were SSA. report a higher proportion T1 prostate tumors countries with...
Deciphering the shared genetic basis of distinct cancers has potential to elucidate carcinogenic mechanisms and inform broadly applicable risk assessment efforts. Here, we undertake genome-wide association studies (GWAS) comprehensive evaluations heritability pleiotropy across 18 cancer types in two large, population-based cohorts: UK Biobank (408,786 European ancestry individuals; 48,961 cases) Kaiser Permanente Genetic Epidemiology Research on Adult Health Aging cohorts (66,526 16,001...
Recently, many new approaches, study designs, and statistical analytical methods have emerged for studying gene-environment interactions (G×Es) in large-scale studies of human populations. There are opportunities this field, particularly with respect to the incorporation -omics next-generation sequencing data continual improvement measures environmental exposures implicated complex disease outcomes. In a workshop called "Current Challenges New Opportunities Gene-Environment Interaction...
Abstract Cancer risk is determined by a complex interplay of environmental and heritable factors. Polygenic scores (PRS) provide personalized genetic susceptibility profile that may be leveraged for disease prediction. Using data from the UK Biobank (413,753 individuals; 22,755 incident cancer cases), we quantify added predictive value integrating cancer-specific PRS with family history modifiable factors 16 cancers. We show incorporating measurably improves prediction accuracy most cancers,...
Waters adjacent to the County of Los Angeles (CA) receive untreated runoff from a series storm drains year round. Many other coastal areas face similar situation. To our knowledge, there has not been large-scale epidemiologic study persons who swim in marine waters subject such runoff. We report here results cohort conducted investigate this issue. Measures exposure included distance drain, selected bacterial indicators (total and fecal coliforms, enterococci, Escherichia coli), direct...
Waters adjacent to the County of Los Angeles (CA) receive untreated runoff from a series storm drains year round. Many other coastal areas face similar situation. To our knowledge, there has not been large-scale epidemiologic study persons who swim in marine waters subject such runoff. We report here results cohort conducted investigate this issue. Measures exposure included distance drain, selected bacterial indicators (total and fecal coliforms, enterococci, Escherichia coli), direct...
Case-control designs that use population controls are compared with those selected from their relatives (i.e., siblings, cousins, or "pseudosibs" based on parental alleles) for estimating the effect of candidate genes and gene-environment interactions. The authors first evaluate asymptotic bias in relative risk estimates resulting using when there is confounding due to stratification. Using siblings pseudosibs as completely addresses this issue, whereas cousins provide only partial...
Abstract Purpose: Sensory peripheral neuropathy is a common and sometimes debilitating toxicity associated with paclitaxel therapy. This study aims to identify genetic risk factors for the development of this toxicity. Experimental Design: A prospective pharmacogenetic analysis patients primary breast cancer, randomized arm CALGB 40101, was used predictors onset severity sensory neuropathy. genome-wide association in 855 subjects European ancestry conducted findings were replicated...
Previous studies suggest that colorectal cancer risk decreases with higher intake of vegetables, fruits, and grains. Few studies, however, have examined these factors in relation to occurrence polyps. The authors used case-control data from 488 matched pairs evaluate associations grains Subjects were southern Californians aged 50-74 years who had a sigmoidoscopy 1991-1993. Diet the year before was measured food frequency questionnaire. Frequent consumption associated decreased polyp...
Genome-wide association studies (GWAS) provide an important avenue for undertaking agnostic evaluation of the between common genetic variants and risk disease. Recent advances in our understanding human variation technology to measure such have made GWAS feasible. Over past few years a multitude identified replicated many associated variants. These findings are enriching knowledge about basis disease leading some advocate using GWA study results testing. For results, however, underlying...
Abstract Purpose: PD-1/L1 axis–directed therapies produce clinical responses in a subset of patients; therefore, biomarkers response are needed. We hypothesized that quantifying key immunosuppression mechanisms within the tumor microenvironment by multiparameter algorithms would identify strong predictors anti–PD-1 response. Experimental Design: Pretreatment biopsies from 166 patients treated with across 10 academic cancer centers were fluorescently stained multiple markers discovery (n =...