A5069014852- Genetic factors in colorectal cancer
- Dialysis and Renal Disease Management
- Colorectal Cancer Screening and Detection
- Genetic and Kidney Cyst Diseases
- Nutritional Studies and Diet
- Genetic Syndromes and Imprinting
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Renal and related cancers
- Colorectal Cancer Treatments and Studies
- Chronic Kidney Disease and Diabetes
- Renal Transplantation Outcomes and Treatments
- Sodium Intake and Health
- Health Systems, Economic Evaluations, Quality of Life
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Central Venous Catheters and Hemodialysis
- Cardiac pacing and defibrillation studies
- Renal and Vascular Pathologies
- Neurological and metabolic disorders
- Muscle and Compartmental Disorders
- Folate and B Vitamins Research
- Liver Disease Diagnosis and Treatment
- Erythropoietin and Anemia Treatment
- Nutrition, Genetics, and Disease
Memorial University of Newfoundland
2015-2024
Nuffield Orthopaedic Centre
2020
University of Oxford
2020
Health Sciences Centre
1995-2016
Mount Sinai Hospital
2007-2015
Lunenfeld-Tanenbaum Research Institute
2007-2015
St. John's School
2014-2015
St. John's University
1996-2013
MRC Epidemiology Unit
2000-2012
University of Toronto
1997-2010
To determine the risk of nephrotoxicity induced by infusion radiographic contrast material, we undertook a prospective study consecutive patients undergoing procedures with intravascular material. There were three groups: diabetes mellitus and normal renal function (n = 85), preexisting insufficiency (serum creatinine level, ≥150 μmol per liter) without 101), both 34). The control group consisted CT scanning or abdominal imaging material who had 59), 145), 64). Clinically important acute...
Individuals who are at risk for autosomal dominant polycystic kidney disease often screened by ultrasound using diagnostic criteria derived from individuals with mutations in PKD1. Families PKD2 typically have less severe disease, suggesting a potential need different criteria. In this study, 577 and 371 at-risk 58 PKD1 39 families, respectively, were assessed renal molecular genotyping. Using sensitivity data genetically affected specificity unaffected individuals, various compared....
The objective of this study was to determine the effect left ventricular (LV) mass, volume, and mass-to-volume ratio on mortality in chronic dialysis patients. Design a multicenter, prospective inception cohort with median follow-up 41 months. Setting three university-affiliated nephrology units. A total 433 patients who (1) survived > 6 months from start ESRD therapy (2) had technically satisfactory baseline echocardiogram were studied. Measurements included clinical, laboratory...
A cohort of 432 ESRD (261 hemodialysis and 171 peritoneal dialysis) patients was followed up prospectively for an average 41 months. Baseline annual demographic, clinical, echocardiographic assessments were performed, as well serial clinical laboratory tests measured monthly while on dialysis therapy. Among patients, after adjustment made age, diabetes, ischemic heart disease, hemoglobin blood pressure levels serially, a 10-g/L fall in mean serum albumin level independently associated with...
Autosomal dominant polycystic kidney disease is usually caused by a mutant gene at the PKD1 locus on short arm of chromosome 16, but in about 4 percent families with disorder it unknown mutations elsewhere genome. The natural course both genetic forms not well characterized.We studied 17 autosomal to compare presymptomatic diagnosis ultrasonography genetic-linkage studies and relate clinical variation whether mutation was implicated.In 10 found cosegregate polymorphic DNA markers flanking...
Bardet-Biedl syndrome (BBS) and Laurence-Moon (LMS) have a similar phenotype, which includes retinal dystrophy, obesity, hypogenitalism. They are differentiated by the presence of spasticity absence polydactyly in LMS. The aims this study were to describe epidemiology BBS LMS, further define examine genotype-phenotype correlation. involved 46 patients (26 males, 20 females) from 26 families, with median age 44 years (range 1-68 years). Assessments performed 1986, 1993, 2001 included...
ABSTRACT. Cardiovascular disease (CVD) is the major cause of death in renal transplant recipients (RTR). Several cohort studies have examined CVD RTR, but none addressed development congestive heart failure (CHF). CHF would hypothetically be a frequent and prognostically important event RTR. A retrolective study was, therefore, conducted two Canadian centers to describe incidence, risk factors for, interrelationships between de novo CHF, ischemic (IHD), mortality 638 consecutive adult RTR...
Abstract. Echocardiographic abnormalities are the rule in patients starting dialysis therapy and associated with development of cardiac failure death. It is unknown, however, whether regression these an improvement prognosis. As part a prospective cohort study mean follow-up 41 mo, 227 had echocardiography at inception after 1 yr therapy. Improvements left ventricular (LV) mass index, volume fractional shortening were seen 48, 46%, respectively. Ninety developed by Twenty-six percent...
The objective of this study was to determine the role hypertension, age, anemia, and hyperparathyroidism in pathogenesis left ventricular hypertrophy (LVH) developing after initiation dialysis for ESRD. A cohort patients who were being treated ESRD whose initial echocardiograms start therapy do not show LVH studied. Three hundred thirty-nine have been monitored at three centers since 1985. Serial performed with M-mode two-dimensional echocardiography. Data on blood pressure, height, weight,...
Being overweight or obese is an established risk factor for colorectal cancer, more so men than women. Approximately 10%-20% of tumors display microsatellite instability (MSI), defined as the expansion contraction small repeated sequences in DNA tumor tissue relative to nearby normal tissue. We evaluated associations between obesity and cancer risk, overall by MSI status.