A5007168761- Dialysis and Renal Disease Management
- Pregnancy and preeclampsia studies
- Central Venous Catheters and Hemodialysis
- Health Systems, Economic Evaluations, Quality of Life
- Maternal and fetal healthcare
- Birth, Development, and Health
- Hemoglobinopathies and Related Disorders
- Chronic Kidney Disease and Diabetes
- Kidney Stones and Urolithiasis Treatments
- Erythropoietin and Anemia Treatment
- Iron Metabolism and Disorders
- Gestational Diabetes Research and Management
- Pediatric Urology and Nephrology Studies
- Healthcare Policy and Management
- Prenatal Screening and Diagnostics
- Muscle and Compartmental Disorders
- Blood Pressure and Hypertension Studies
- Electrolyte and hormonal disorders
- Pharmacological Effects and Toxicity Studies
- Pregnancy and Medication Impact
- Global Maternal and Child Health
- Hemodynamic Monitoring and Therapy
- Renal Transplantation Outcomes and Treatments
- Maternal and Perinatal Health Interventions
- Organ Donation and Transplantation
New Cross Hospital
2011-2024
National Health Service
2024
University of Wolverhampton
2002-2024
Wolverhampton Hospital
2006-2024
The Royal Wolverhampton NHS Trust
2006-2024
Government of the United Kingdom
2023
McMaster University
2000-2018
King's College London
2012-2018
St Thomas' Hospital
2018
University of Toronto
1989-2018
Abstract. Studies of the adequacy peritoneal dialysis and recommendations have assumed that renal clearances are comparable therefore additive. The CANUSA data were reanalyzed in an effort to address this assumption. Among 680 patients original study, 601 had all variables interest for report. Adequacy was estimated from GFR (mean urea creatinine clearance) clearance. Cox proportional-hazards model used evaluate time-dependent association these independent with patient survival. For each 5...
The objective of this study was to evaluate the association peritoneal membrane transport with technique and patient survival. In Canada-USA prospective cohort adequacy continuous ambulatory dialysis (CAPD), a equilibrium test (PET) performed approximately 1 mo after initiation dialysis; patients were defined as high (H), average (HA), low (LA), (L) transporters. Cox proportional hazards method evaluated survival independent variables (demographic clinical variables, nutrition, adequacy,...
A NEW paradigm for medical practice is emerging. Evidence-based medicine de-emphasizes intuition, unsystematic clinical experience, and pathophysiologic rationale as sufficient grounds decision making stresses the examination of evidence from research. requires new skills physician, including efficient literature searching application formal rules evaluating literature. An important goal our residency program to educate physicians in evidence-based medicine. Strategies include a weekly,...
Autosomal dominant polycystic kidney disease is usually caused by a mutant gene at the PKD1 locus on short arm of chromosome 16, but in about 4 percent families with disorder it unknown mutations elsewhere genome. The natural course both genetic forms not well characterized.We studied 17 autosomal to compare presymptomatic diagnosis ultrasonography genetic-linkage studies and relate clinical variation whether mutation was implicated.In 10 found cosegregate polymorphic DNA markers flanking...
Hyperhomocysteinemia is frequently observed in patients with diabetic nephropathy. B-vitamin therapy (folic acid, vitamin B(6), and B(12)) has been shown to lower the plasma concentration of homocysteine.To determine whether can slow progression nephropathy prevent vascular complications.A multicenter, randomized, double-blind, placebo-controlled trial (Diabetic Intervention Vitamins Improve Nephropathy [DIVINe]) at 5 university medical centers Canada conducted between May 2001 July 2007 238...
BackgroundIn women with late preterm pre-eclampsia, the optimal time to initiate delivery is unclear because limitation of maternal disease progression needs be balanced against infant complications. The aim this trial was determine whether planned earlier initiation reduces adverse outcomes without substantial worsening neonatal or outcomes, compared expectant management (usual care) in pre-eclampsia.MethodsIn parallel-group, non-masked, multicentre, randomised controlled done 46 maternity...
Background: Two small, randomized trials provide conflicting evidence about the benefits of plasma exchange for patients with acute renal failure at onset multiple myeloma. Objective: To assess effect 5 to 7 exchanges on a composite outcome in Design: Randomized, open, controlled trial, stratified by chemotherapy and dialysis dependence, conducted from 1998 2004. Setting: Hospital units 14 Canadian medical centers. Participants: 104 between 18 81 years age Intervention: Study participants...
Abstract. In population-based studies, renal transplantation has been shown to improve survival compared dialysis patients awaiting in the United States. However, mortality States is higher than Canada. Whether offers a advantage regions where superior that uncertain. This study examines cohort of 1156 who started end-stage disease (ESRD) therapy and were wait-listed for cadaveric province Ontario, Canada between January 1, 1990 December 31, 1994. Patients followed from wait-listing...
RUSSELL, J. DAVID; BEECROFT, MARY LOUISE; LUDWIN, CHURCHILL, DAVID N. Author Information
Regular vascular access blood flow (Qa) surveillance is recommended to detect graft stenosis; however, there little evidence that monitoring and correcting with angioplasty improves survival. This blinded, randomized, controlled trial of 112 patients studied time thrombosis loss, comparing monthly Qa plus standard (dynamic venous pressure physical examination) (treatment group) alone (control group). Only the treatment group was referred for angiogram if <650 ml/min or a 20% decrease in from...
An inception cohort of 107 patients was reviewed to establish the natural history asymptomatic urolithiasis. With an over-all mean followup 31.6 months, 73 (68.2%) remained and were censored at time last clinical visit. A symptomatic event developed in 34 (31.8%). Spontaneous passage occurred 16 (15.0%), endoureteral removal done 6 (5.6%), percutaneous nephrostolithotomy 3 (2.8%) 9 (8.4%) referred for therapeutic lithotripsy. Cumulative 5-year probability a developing 48.5%. linear...
Abstract Few reports are available on the age‐related risk of relatives affected persons to manifest adult polycystic kidney disease (APKD). For 371 in 17 kindreds, at for APKD by virtue having an first degree relative, we calculated estimated probability clinical diagnosis be 0.011 age 20, 0.041 30, 0.115 40, 0.299 50, and 0.404 60 years (expected = 0.50). Ultrasonographic examination 172 asymptomatic showed definite is 60. The ultrasonographic detection as 0.222, 0.657, 0.855 5, 15, 25...
<h3>Importance</h3> Inadequate management of elevated blood pressure (BP) is a significant contributing factor to maternal deaths. Self-monitoring BP in the general population has been shown improve diagnosis and hypertension; however, little known about its use pregnancy. <h3>Objective</h3> To determine whether self-monitoring higher-risk pregnancies leads earlier detection pregnancy hypertension. <h3>Design, Setting, Participants</h3> Unblinded, randomized clinical trial that included 2441...
Inadequate management of elevated blood pressure is a significant contributing factor to maternal deaths. The role self-monitoring in pregnancy improving clinical outcomes for the pregnant individual and infant unclear.To evaluate effect self-monitoring, compared with usual care alone, on control other related outcomes, individuals hypertension.Unblinded, randomized trial that recruited between November 2018 September 2019 15 hospital maternity units England. Individuals chronic hypertension...
Data from the Canada-U.S.A. (CANUSA) Study have recently confirmed a long-suspected linkage between total clearance and patient survival in peritoneal dialysis (PD). Recognizing that what we historically accepted as adequate PD simply is not, Ad Hoc Committee on Peritoneal Dialysis Adequacy met January, 1996. This committee of invited experts was convened by Baxter Healthcare Corporation to prepare consensus statement provides clinical recommendations for achieving guidelines dialysis....