A5002142990- Complement system in diseases
- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Advancements in Semiconductor Devices and Circuit Design
- Semiconductor materials and devices
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Viral gastroenteritis research and epidemiology
- Blood groups and transfusion
- Platelet Disorders and Treatments
- Renal Transplantation Outcomes and Treatments
- Systemic Lupus Erythematosus Research
- Acute Kidney Injury Research
- Vasculitis and related conditions
- Electrolyte and hormonal disorders
- Fatty Acid Research and Health
- Gastrointestinal motility and disorders
- Escherichia coli research studies
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Iron Metabolism and Disorders
- Neonatal Health and Biochemistry
- Hemoglobinopathies and Related Disorders
- Cholesterol and Lipid Metabolism
- Metabolism and Genetic Disorders
Western University
2012-2022
London Health Sciences Centre
2010-2020
Coventor (France)
2016-2017
Victoria Hospital
1980-2017
Canadian Apheresis Group
1999-2017
Lawson Health Research Institute
2009-2016
Western University of Health Sciences
2015
Humber River Regional Hospital
2014
McMaster University
2001-2014
Ottawa Hospital
1999-2014
Evidence from animal and human studies suggests a protective effect of higher water intake on kidney function cardiovascular disease (CVD). Here the associations between intake, chronic (CKD) CVD were examined in general population.We conducted cross-sectional analysis 2005-2006 National Health Nutrition Examination Survey. Non-pregnant adults with an estimated glomerular filtration rate (eGFR) ≥30 ml/min/1.73 m(2) who not taking diuretics included. Total foods beverages was categorized as...
More effective and safer treatments are needed for antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis.
Granulomatosis with polyangiitis (GPA, Wegener's) and microscopic (MPA) are small vessel vasculitides collectively referred to as anti-neutrophil cytoplasm antibody-associated vasculitis (AAV). AAV is associated high rates of morbidity mortality due uncontrolled disease treatment toxicity. Small randomized trials suggest adjunctive plasma exchange may improve control, while observational evidence suggests that current oral glucocorticoid doses severe infections in patients AAV. A study both...
Rationale: Diffuse alveolar hemorrhage (DAH) is a life-threatening manifestation of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The Plasma Exchange (PLEX) and Glucocorticoids (GC) in Severe AAV (PEXIVAS;NCT00987389) trial was the largest first to enroll participants with DAH requiring mechanical ventilation. Objectives: Evaluate characteristics, treatment effects, outcomes for patients without DAH. Methods: PEXIVAS randomized 704 PLEX or no-PLEX reduced...
Background: Two small, randomized trials provide conflicting evidence about the benefits of plasma exchange for patients with acute renal failure at onset multiple myeloma. Objective: To assess effect 5 to 7 exchanges on a composite outcome in Design: Randomized, open, controlled trial, stratified by chemotherapy and dialysis dependence, conducted from 1998 2004. Setting: Hospital units 14 Canadian medical centers. Participants: 104 between 18 81 years age Intervention: Study participants...
Summary Background : Post‐infectious irritable bowel syndrome is a common clinical phenomenon of uncertain aetiology. Aim To test the association between intestinal permeability and symptoms 2 years after large waterborne outbreak bacterial gastroenteritis. Methods Consecutive adults with Rome I controls without attending community clinic were enrolled. Intestinal was measured as ratio fractional urinary excretions lactulose mannitol, compared among cases vs. predictors abnormal assessed....
<h3>Background</h3> Although postinfectious irritable bowel syndrome (PI-IBS) is a well-recognised complication of acute gastroenteritis, its prognosis remains poorly defined. The natural history PI-IBS was assessed among participants in the Walkerton Health Study (WHS), which has followed long-term effects large outbreak gastroenteritis related to municipal water contamination May 2000. <h3>Methods</h3> WHS were invited return for annual assessment at research clinic. Adult residents time...
Summary Background and objectives The effect of increased fluid intake on kidney function is unclear. This study evaluates the relationship between urine volume renal decline over 6 years in a large community-based cohort. Design, setting, participants, & measurements prospective cohort was undertaken Canada from 2002 to 2008. We obtained 24-hour samples adult participants with an estimated GFR (eGFR) ≥60ml/min per 1.73 m 2 at entry. Percentage annual change eGFR baseline categorized as...
A dramatic increase in the "early start" of dialysis with an estimated glomerular filtration rate (eGFR) at least 10 mL/min/1.73 m(2) has occurred United States since 1996. Several recent studies have reported a comorbidity-adjusted survival disadvantage early start dialysis. The current study examines relatively "healthy" cohort to minimize confounding issues and determine whether initiation hemodialysis is associated benefit or harm.We examined demographics, year initiation, primary...
OBJECTIVE. Childhood overweight and obesity may result in premature onset of cardiovascular risk factors such as hypertension. Rural populations North America be at increased for overweight. We evaluated whether were associated with prehypertension hypertension a well-characterized population children rural Canada. METHODS. The study this cross-sectional was composed (aged 4–17 years) who participants the Walkerton Health Study (Canada) 2004. Prehypertension defined on basis percentiles from...
Initiating chronic dialysis has major implications for patients and health care systems. Within the spectrum of severity kidney disease, there is a need to identify threshold before which starting offers no benefit patient but beyond may be some measurable
<h3>Importance</h3> In observational studies, increased water intake is associated with better kidney function. <h3>Objective</h3> To determine the effect of coaching to increase on function in adults chronic disease. <h3>Design, Setting, and Participants</h3> The CKD WIT (Chronic Kidney Disease Water Intake Trial) randomized clinical trial was conducted 9 centers Ontario, Canada, from 2013 until 2017 (last day follow-up, May 25, 2017). Patients had stage 3 disease (estimated glomerular...
In 1997, the Canadian Apheresis Group reviewed data on 103,416 plasma exchange procedures that had been collected since 1980. Although number of exchanges gradually increased (from 3189 to 8208 per year), pattern changed. 1981, five most frequent indications for resulted in 55% all such procedures; by 81.1% procedures. During this period, three conditions were originally among became least frequent. This paper reviews published evidence supports or refutes use category from 1981 1997:...
For the first time, tensile and compressively stressed nitride contact liners have been simultaneously incorporated into a high performance CMOS flow. This dual stress liner (DSL) approach results in NFET/PFET effective drive current enhancement of 15%/32% saturated 11%/20%. Significant hole mobility 60% is achieved without using SiGe. Inverter ring oscillator delay reduced by 24% with DSL. Overall yield for DSL process comparable to that similar technology Single multi-core SOI...