A5090535973- Mitochondrial Function and Pathology
- Nerve injury and regeneration
- Alzheimer's disease research and treatments
- ATP Synthase and ATPases Research
- Metabolism and Genetic Disorders
- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Canadian Identity and History
- Vestibular and auditory disorders
- Biochemical Acid Research Studies
- Ion channel regulation and function
- Erythrocyte Function and Pathophysiology
- Pneumonia and Respiratory Infections
- Neuroscience and Neuropharmacology Research
- Pluripotent Stem Cells Research
- Autophagy in Disease and Therapy
- Sports Performance and Training
- Research in Social Sciences
- Contemporary Sociological Theory and Practice
- Neurological disorders and treatments
- Robotics and Automated Systems
- Aging and Gerontology Research
- Asthma and respiratory diseases
- Chemical and Physical Studies
- Chinese history and philosophy
Max Delbrück Center
2023-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2022
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2022
Vita-Salute San Raffaele University
2022
University of Padua
2017-2021
University of Milan
1989-2012
Bambino Gesù Children's Hospital
2011
Institute of Neurological Sciences
1991
PSEN2 (presenilin 2) is one of the 3 proteins that, when mutated, causes early onset familial Alzheimer disease (FAD) cases. In addition to its well-known role within γ-secretase complex (the enzyme ultimately responsible for Aβ peptides formation), endowed with some γ-secretase-independent functions in distinct cell signaling pathways, such as modulation intracellular Ca
Mitochondria are key organelles for brain health. Mitochondrial alterations have been reported in several neurodegenerative disorders, including Alzheimer's disease (AD), and the comprehension of underlying mechanisms appears crucial to understand their relationship with pathology. Using multiple genetic, pharmacological, imaging, biochemical approaches, we demonstrate that, different familial AD cell models, mitochondrial ATP synthesis is affected. The defect depends on reduced pyruvate...
<h3>Importance</h3> Inadequate management of elevated blood pressure (BP) is a significant contributing factor to maternal deaths. Self-monitoring BP in the general population has been shown improve diagnosis and hypertension; however, little known about its use pregnancy. <h3>Objective</h3> To determine whether self-monitoring higher-risk pregnancies leads earlier detection pregnancy hypertension. <h3>Design, Setting, Participants</h3> Unblinded, randomized clinical trial that included 2441...
Touch perception is enabled by mechanically activated ion channels, the opening of which excites cutaneous sensory endings to initiate sensation. In this study, we identify ELKIN1 as an channel likely gated mechanical force, necessary for normal touch sensitivity in mice. insensitivity
Here are, as Alice Rossi claims in her well-written preface, 'the essential works of feminism, ' published over a period 200 years. Her introductions to each section are informative and written with nonpolemical grace. -- Doris Grumbach, New Republic
Over the last decade, it has been proved that mesenchymal stem cells (MSCs) elicit anti-inflammatory effects. MSCs from adipose tissue (hASCs) differentiate into of mesodermal lineage and transdifferentiate ectodermal-origin cells. Although there are various etiologies to chronic pain, one common feature is painful states associated with increased inflammation. We believe in hASCs as a therapeutic tool also pathologies involving neuroinflammation neuronal damage. have investigated effect...
• Evoked potentials are reported in 10 patients with cerebrotendinous xanthomatosis, eight of whom had peripheral neuropathy. Four subjects showed delayed N13 to N20 interpeak latencies for arm somatosensory evoked potentials, and five moderately prolonged I III V brain-stem auditory potentials. Six seven marked delay desynchronization visual All undergoing transcutaneous magnetic stimulation the motor cortex presented greatly central conduction time, especially lower limbs. After treatment...
Alzheimer′s disease (AD) is the most common age-related neurodegenerative disorder in which learning, memory and cognitive functions decline progressively. Familial forms of AD (FAD) are caused by mutations amyloid precursor protein (APP), presenilin 1 (PSEN1) 2 (PSEN2) genes. Presenilin (PS1) its homologue, (PS2), represent, alternatively, catalytic core γ-secretase complex that, cleaving APP, produces neurotoxic beta (Aβ) peptides responsible for one histopathological hallmarks brains,...
The Free and Cued Selective Reminding test (FCSRT) was used to assess memory in 19 patients with prodromal dementia Lewy bodies (DLB) 25 Alzheimer's disease (AD) patients. DLB scored better than AD selective measures of the FCSRT: immediate total recall (p = 0.01) index sensitivity cueing 0.001), while free delayed scores were similarly impaired. held a 76% specificity 79% distinguishing DLB. FCSRT could help disentangling hippocampal deficits from impairment due ineffective strategies.
Mitochondria and neuronal activity: The brain is one of the highest energy demanding organs, consuming ~20% total ATP produced by whole body. Importantly, neurons mainly rely on synthesized mitochondrial bioenergetics activity strictly dependent specific localization at synapses, sites a high amount requested for both pre- post-synaptic processes. Here, mitochondria produce buffer Ca2+ rises, two essential processes neurotransmission generation membrane potential along axon (Magistretti...
Abstract The slightest touch to the skin initiates tactile perception that is almost immediate 1 . extraordinary speed of enabled by mechanically-activated ion channels, opening which excites endings sensory neurons innervating initiate sensation. Here we identify a new channel, Elkin1 2 , that, when ablated in mice, leads profound behavioural insensitivity. Touch insensitivity -/- mice was caused loss currents (MA-currents) around half all are activated light (low threshold...
Oxygen deprivation or hypoxia is poorly dealt with by most terrestrial species and often leads to permanent tissue damage death. One prominent exception the naked mole-rat (Heterocephalus glaber) which remarkably adapted withstand prolonged periods (~18 mins) of severe hypoxia, a trait likely driven its crowded underground lifestyle. Other African are less social entirely solitary like Cape (Georychus capensis). Here, we asked whether cellular molecular adaptations map traits. We discovered...
The neuropathic pain is a disabling condition which occurs secondarily to injury of peripheral or central nervous system. To date, the neuronal basis are poorly understood and effective treatments with long lasting relief not available. Stem cells represent more innovative interesting therapeutic approach for tissue damage restoration. This study evaluates effect intravenous administration murine adult stem in lateral cerebral ventricle human mesenchymal two animal models mononeuropathy:...