A5068371692- Mitochondrial Function and Pathology
- Endoplasmic Reticulum Stress and Disease
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Ion channel regulation and function
- Autophagy in Disease and Therapy
- Neuroscience and Neuropharmacology Research
- ATP Synthase and ATPases Research
- Cellular transport and secretion
- Genetic Neurodegenerative Diseases
- Lipid Membrane Structure and Behavior
- Genetics and Neurodevelopmental Disorders
- Calcium signaling and nucleotide metabolism
- Neurological disorders and treatments
- Pancreatic function and diabetes
- Neurological diseases and metabolism
- Amyotrophic Lateral Sclerosis Research
- Metabolism and Genetic Disorders
- Signaling Pathways in Disease
- Adipose Tissue and Metabolism
- Glycosylation and Glycoproteins Research
- Ubiquitin and proteasome pathways
- Advanced Fluorescence Microscopy Techniques
- Erythrocyte Function and Pathophysiology
- Prion Diseases and Protein Misfolding
University of Padua
2016-2025
Institute of Oncology Research
2008
Contact sites are discrete areas of organelle proximity that coordinate essential physiological processes across membranes, including Ca2+ signaling, lipid biosynthesis, apoptosis, and autophagy. However, tools to easily image inter-organelle over a range distances in living cells vivo lacking. Here we report split-GFP-based contact site sensor (SPLICS) engineered fluoresce when organelles proximity. Two SPLICS versions efficiently measured narrow (8-10 nm) wide (40-50 juxtapositions between...
DJ-1 was first identified as an oncogene. More recently, mutations in its gene have been found causative for autosomal recessive familial Parkinson disease. Numerous studies support the role protection against oxidative stress and maintenance of mitochondria structure; however, mechanism protective function remains largely unknown. We investigated whether mitochondrial Ca2+ homeostasis, a key parameter cell physiology, could be target action. Here, we show that modulates transients induced...
Signaling between the endoplasmic reticulum (ER) and mitochondria regulates a number of key neuronal functions. This signaling involves close physical contacts two organelles that are mediated by "tethering proteins" function to recruit regions ER mitochondrial surface. The protein, vesicle-associated membrane protein-associated protein B (VAPB) tyrosine phosphatase interacting protein-51 (PTPIP51), interact form one such tether. Recently, damage ER-mitochondria involving disruption...
Ca 2+ in neurons is vital to processes such as neurotransmission, neurotoxicity, synaptic development, and gene expression. Disruption of homeostasis occurs brain aging neurodegenerative disorders. Membrane transporters, among them the calmodulin (CaM)-activated plasma membrane ATPases (PMCAs) that extrude from cell, play a key role neuronal homeostasis. Using X-exome sequencing we have identified missense mutation (G1107D) CaM-binding domain isoform 3 PMCAs family with X-linked congenital...
Article29 March 2018Open Access Transparent process Alpha-synuclein aggregates activate calcium pump SERCA leading to dysregulation Cristine Betzer orcid.org/0000-0001-5429-3548 Danish Research Institute of Translational Neuroscience – DANDRITE, Aarhus University, Aarhus, Denmark Department Biomedicine, Search for more papers by this author Louise Berkhoudt Lassen Anders Olsen Molecular Biology and Genetics, Rikke Hahn Kofoed Lasse Reimer Emil Gregersen Jin Zheng Tito Calì Biomedical...