A5058093044- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Radiopharmaceutical Chemistry and Applications
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Virus-based gene therapy research
- Cancer Treatment and Pharmacology
- Medical Imaging Techniques and Applications
- Breast Cancer Treatment Studies
- S100 Proteins and Annexins
- T-cell and B-cell Immunology
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Bone health and treatments
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Medical Imaging and Pathology Studies
- Advanced Radiotherapy Techniques
- Nanoparticle-Based Drug Delivery
Istituto Oncologico Veneto
2016-2025
University of Padua
2016-2025
IRCCS Policlinico San Donato
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2024
Ospedale Policlinico San Martino
2023
University Hospital of Zurich
2023
University of Siena
2023
Weatherford College
2023
University of Campania "Luigi Vanvitelli"
2020
Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro
2005-2018
Triple-negative breast cancer (TNBC) represents the most aggressive tumor subtype. However, molecular determinants responsible for metastatic TNBC phenotype are only partially understood. We here show that expression of mitochondrial calcium uniporter (MCU), selective channel Ca(2+) uptake, correlates with size and lymph node infiltration, suggesting uptake might be instrumental growth formation. Accordingly, MCU downregulation hampered cell motility invasiveness reduced growth, lung...
Diagnostic approaches based on multimodal imaging are needed for accurate selection of the therapeutic regimens in several diseases, although dose administered contrast drugs must be reduced to minimize side effects. Therefore, large efforts deployed development agents (MCAs) that permit complementary visualization same diseased area with different sensitivity and spatial resolution by applying multiple diagnostic techniques. Ideally, MCAs should also allow tissues high during surgical...
Abstract The Hippo pathway is an oncosuppressor signalling cascade that plays a major role in the control of cell growth, tissue homoeostasis and organ size. Dysregulation leads to aberrant activation transcription co-activator YAP (Yes-associated protein) contributes tumorigenesis several tissues. Here we identify glucocorticoids (GCs) as hormonal activators YAP. Stimulation glucocorticoid receptor (GR) increase protein levels, nuclear accumulation transcriptional activity vitro vivo ....
Abstract Mammary epithelial stem cells are fundamental to maintain tissue integrity. Cancer (CSCs) implicated in both treatment resistance and disease relapse, the molecular bases of their malignant properties still poorly understood. Here we show that normal CSCs breast controlled by prolyl‐isomerase Pin1. Mechanistically, following interaction with Pin1, Notch1 Notch4, key regulators cell fate, escape from proteasomal degradation major ubiquitin‐ligase Fbxw7α. Functionally, Fbxw7α acts as...
Breast cancer is a heterogeneous disease that progresses to the critical hallmark of metastasis. In present study, we show High Mobility Group A1 (HMGA1) protein plays fundamental role in this process basal-like breast subtype. HMGA1 knockdown induces mesenchymal epithelial transition and dramatically decreases stemness self-renewal. Notably, depletion cell lines reduced migration invasion vitro formation metastases vivo. Mechanistically, activated key migration-associated genes which were...
Abstract The prolyl isomerase PIN1, a critical modifier of multiple signalling pathways, is overexpressed in the majority cancers and its activity strongly contributes to tumour initiation progression. Inactivation PIN1 function conversely curbs growth cancer stem cell expansion, restores chemosensitivity blocks metastatic spread, thus providing rationale for therapeutic strategy based on inhibition. Notwithstanding, potent inhibitors are still missing from arsenal anti-cancer drugs. By...
Immune checkpoint inhibitors (ICI) are approved for treatment of recurrent or metastatic oropharyngeal head and neck squamous cell carcinoma in the first- second-line settings. However, only 15-20% patients benefit from this treatment, a feature increasingly ascribed to peculiar characteristics tumor immune microenvironment (TIME).