A5068649274- Cancer-related molecular mechanisms research
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- RNA modifications and cancer
- Developmental Biology and Gene Regulation
- melanin and skin pigmentation
- Hippo pathway signaling and YAP/TAZ
- DNA Repair Mechanisms
- Bioinformatics and Genomic Networks
- Radiomics and Machine Learning in Medical Imaging
- Genetic factors in colorectal cancer
- Histone Deacetylase Inhibitors Research
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Chemokine receptors and signaling
- Wnt/β-catenin signaling in development and cancer
- FOXO transcription factor regulation
- Nuclear Receptors and Signaling
- RNA Interference and Gene Delivery
Radboud University Nijmegen
2025
Radboud University Medical Center
2025
Italian Institute of Technology
2025
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2023
University of Trieste
2011-2022
Breast cancer is a heterogeneous disease that progresses to the critical hallmark of metastasis. In present study, we show High Mobility Group A1 (HMGA1) protein plays fundamental role in this process basal-like breast subtype. HMGA1 knockdown induces mesenchymal epithelial transition and dramatically decreases stemness self-renewal. Notably, depletion cell lines reduced migration invasion vitro formation metastases vivo. Mechanistically, activated key migration-associated genes which were...
Breast cancer is the most common malignancy in women worldwide. Among breast subtypes, triple-negative (TNBC) aggressive and difficult to treat. One of master regulators TNBC progression architectural transcription factor HMGA1. This study aimed further explore HMGA1 molecular network identify mechanisms involved progression.RNA from MDA-MB-231 cell line, silenced for expression, was sequenced and, with a bioinformatic analysis, partners could cooperate regulating downstream gene networks...
// Silvia Pegoraro 1,* , Gloria Ros Yari Ciani 1,2 Riccardo Sgarra 1 Silvano Piazza 2 and Guidalberto Manfioletti Dipartimento di Scienze della Vita, Università degli Studi Trieste, Italy Laboratorio Nazionale CIB (LNCIB), Area Science Park, * These authors have contributed equally to this work Correspondence to: Manfioletti, email: Piazza, Keywords : cyclin E2, YAP/TAZ, hippo pathway, CDK inhibitors, oncogene/tumour suppressor Received October 20, 2014 Accepted May 12, 2015 Published 22,...
Background Natural antisense long non-coding RNAs (lncRNAs) are regulatory transcribed from the opposite strand of either protein coding or genes, able to modulate their own sense gene expression. Hence, dysregulation can lead pathologic processes. Cancer is a complex class diseases determined by aberrant expression variety factors, among them, oncofetal chromatin architectural proteins High Mobility Group A (HMGA) several cancer hallmarks. Thus, we decided investigate presence natural...
SINEUPs are natural and synthetic antisense long non-coding RNAs (lncRNAs) selectively enhancing target mRNAs translation by increasing their association with polysomes. This activity requires two RNA domains: an embedded inverted SINEB2 element acting as effector domain, region, the binding conferring selectivity. SINEUP technology presents several advantages to treat genetic (haploinsufficiencies) complex diseases restoring physiological of diseased genes compensatory pathways. To...
The HMGA1 architectural transcription factor is an oncogene overexpressed in the vast majority of human cancers. a highly connected node nuclear molecular network and key aspect involvement cancer development that simultaneously confers cells multiple oncogenic hits, ranging from global chromatin structural gene expression modifications up to direct functional alterations cellular proteins. Interestingly, also modulates DNA damage repair pathways. In this work, we provide evidences linking...
Chromatin accessibility plays a critical factor in regulating gene expression cancer cells. Several factors, including the High Mobility Group A (HMGA) family members, are known to participate directly chromatin relaxation and transcriptional activation. The HMGA1 oncogene encodes an architectural transcription that alters DNA structure interacts with factors favouring their landing onto regulatory sequences. Here, we provide evidence of additional mechanism exploited by modulate...
Abstract High Mobility Group A1 (HMGA1) is an architectural chromatin factor involved in the regulation of gene expression and a master regulator Triple Negative Breast Cancer (TNBC). In TNBC, HMGA1 overexpressed coordinates network that controls cellular processes tumour development, progression, metastasis formation. Here, we find microtubule-destabilizing protein stathmin correlates breast cancer (BC) patients. We demonstrate depletion leads to downregulation activity on microtubules...
High Mobility Group A proteins (HMGA1 and HMGA2) are architectural nuclear factors involved in development, cell differentiation, cancer formation progression. Here we report the cloning, developmental expression functional analysis of a new multi-AT-hook factor Xenopus laevis (XHMG-AT-hook) that exists three different isoforms. Xhmg-at-hook1 3 isoforms, but not isoform 2, expressed throughout entire development Xenopus, both maternal zygotic phase. Localized transcripts present animal pole...