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Willem Tielemans

ORCID: 0009-0004-2670-509X
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About
Contact & Profiles
A5093131138
Research Areas
  • RNA Interference and Gene Delivery
  • Extracellular vesicles in disease
  • Advanced biosensing and bioanalysis techniques
  • Phagocytosis and Immune Regulation
  • Immune Cell Function and Interaction

Radboud University Nijmegen
 2023-2025

Radboud University Medical Center
 2023-2025

University Medical Center
 2023

 Nature-inspired platform nanotechnology for RNA delivery to myeloid cells and their bone marrow progenitors
OPENALEX - Publications 
Stijn R. J. Hofstraat Tom Anbergen Robby Zwolsman Jeroen Deckers Yuri van Elsas and 29 more Mirre M. Trines Iris Versteeg Daniek Hoorn Gloria Ros Branca M. Bartelet M. Hendrikx Y. Darwish Teun Kleuskens Francisca Borges Rianne J. F. Maas Lars M. Verhalle Willem Tielemans Pieter Vader Olivier G. de Jong Tommaso Tabaglio Dave Keng Boon Wee Abraham J. P. Teunissen Eliane E.S. Brechbühl Henk M. Janssen Peter Fransen Anne de Dreu David P. Schrijver Bram Priem Yohana Camila Antunes Frederico Thijs J. Beldman Mihai G. Netea Willem J. M. Mulder Ewelina Kluza Roy van der Meel

10.1038/s41565-024-01847-3 article EN cc-by Nature Nanotechnology 2025-02-03
 A nature-inspired nanodelivery platform for gene silencing in hematopoietic stem and progenitor cells
OPENALEX - Publications 
Roy van der Meel Stijn R. J. Hofstraat Tom Anbergen Robby Zwolsman Jeroen Deckers and 23 more Yuri van Elsas Mirre M. Trines Iris Versteeg Bram Priem Y. Darwish Teun Kleuskens Francisca Borges Rianne J. F. Maas Lars M. Verhalle Willem Tielemans Pieter Vader Olivier G. de Jong Abraham J. P. Teunissen Eliane E.S. Brechbühl Henk M. Janssen Michel Fransen Anne de Dreu David P. Schrijver Yohana C. Toner Thijs J. Beldman Mihai G. Netea Willem J. M. Mulder Ewelina Kluza

Abstract Nucleic acid therapeutics harbor great potential for silencing, expressing, or editing genes. Here, we introduce a nanodelivery platform based on natural lipoproteins, which prevents premature degradation of small interfering RNA (siRNA), ensuring its targeted and intracellular delivery to hematopoietic stem progenitor cells (HSPCs) in the bone marrow. After establishing prototype apolipoprotein lipid nanoparticle (aNP) that stably incorporates siRNA core, built comprehensive...

10.21203/rs.3.rs-3458536/v1 preprint EN cc-by Research Square (Research Square) 2023-10-27
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