A5063525547- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Genetic factors in colorectal cancer
- Liver physiology and pathology
- Microscopic Colitis
- Hepatitis C virus research
- Celiac Disease Research and Management
- Hernia repair and management
- Inflammatory Bowel Disease
- Immune Response and Inflammation
- Gut microbiota and health
- Alcohol Consumption and Health Effects
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Gastrointestinal Tumor Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Gastrointestinal disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Trace Elements in Health
- Barrier Structure and Function Studies
- Stoma care and complications
- Heavy Metal Exposure and Toxicity
- Pelvic and Acetabular Injuries
- Cytomegalovirus and herpesvirus research
- Diabetes and associated disorders
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2018-2021
Universidade de São Paulo
2017-2020
Centro Universitário das Faculdades Metropolitanas Unidas
2019
University of Padua
2006-2018
Regione del Veneto
2015
Policlinico Universitario di Catania
2015
University of Graz
2010
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2010
American Gastroenterological Association
2009
RWTH Aachen University
2006
A small percentage of pathologically obese subjects with fatty livers develop histological signs necroinflammation and fibrosis, suggesting a variety cofactors in the pathogenesis obesity-related liver diseases including nonalcoholic steatohepatitis. Since several observations have linked bacterial endotoxins to damage, aim this study was determine effect obesity on intestinal mucosal integrity portal blood endotoxemia two strains mice: leptin-deficient (ob/ob) hyperleptinemic (db/db) mice....
The clinical course of Crohn's disease is often unpredictable. aim this study was to select the most useful parameters able predict relapses.One hundred-thirty patients in remission were followed every 4 months for 2 yr or until relapse. Demographic and data recorded intestinal permeability (lactulose/mannitol [L/M] test) biochemical tests (white blood cell count, erythrocyte sedimentation rate, C-reactive protein, alpha1 acid glycoprotein, serum iron) performed at entry. A subgroup 54 had...
Oxidative stress is believed to play a key role in the pathogenesis of inflammatory bowel disease (IBD)-related intestinal damage. Circulating antioxidants may have preventing free radical-mediated tissue injury.Plasma vitamin A, E and carotenoid concentrations, leukocytic genomic damage 8-hydroxy-deoxy-guanosine (8-OHdG) concentration were determined 46 ulcerative colitis (UC) patients, 37 Crohn (CD) patients 386 controls. A 20 ml blood sample was taken from each subject for antioxidant...
To report on the diagnostic features, management, and clinical outcome after different treatments of Wilson's disease patients followed over a mean period 15 years.Thirty-five with referred to University Padova's Department Gastroenterology for diagnosis or treatment were observed years. The was based symptoms, laboratory tests (ceruloplasmin, urinary, hepatic copper concentrations), uptake radiostable isotope Cu into plasma protein pool. Hepatic content measured by regular follow-up...
Activated hepatic stellate cells (HSCs) secrete extracellular matrix components during fibrosis, but recent studies have shown that HSCs can also release a variety of proinflammatory cytokines. Moreover, bacterial endotoxemia is not only associated with systemic complications in the late stages liver failure direct cause damage, activating resident inflammatory cells. In this study, we investigated whether respond directly to cell wall products acquiring new phenotype. RT-PCR and...
Chronic inflammation may contribute to cancer risk through the accumulation of specific products as a result DNA damage. The role free radical mediated oxidative damage during was determined in patients with ulcerative colitis by measuring 8-hydroxydeoxyguanosine (8-OHdG).Patients were compared according age, gender, duration and extent disease, endoscopic histologic activity, presence or absence dysplasia/cancer, biochemical parameters inflammation. Patients sporadic colon irritable bowel...
Hepatocellular carcinoma (HCC) and liver cirrhosis (LC) are not well-established vinyl chloride monomer (VCM)-induced diseases. Our aim was to appraise the role of VCM, alcohol intake, viral hepatitis infection, their interactions, in etiology HCC LC. Thirteen cases 40 LC were separately compared with 139 referents without chronic diseases or cancer a case-referent study nested cohort 1,658 VCM workers. The odds ratios (ORs) 95% confidence intervals (CIs) estimated by common methods fitting...
ABSTRACT The colonic microbiota is a major modulator of the mucosal immune system; therefore, its manipulation through supplementation with probiotics may significantly affect host's responses. Since different seem to exert various effects in vivo, we tested relevance autoaggregation phenotype on intestinal persistence lactobacilli and their ability modulate innate After 14 days diet supplementation, aggregating strain Lactobacillus crispatus M247 but not aggregation-deficient isogenic...
Cingulin (CGN) is a 140 kDa protein, which localized to the cytoplasmic region of vertebrate tight junctions (TJ), and regulates gene expression RhoA signaling in cultured cells. To investigate function CGN at organism level, we generated knockout (CGN(-/-)) mice by homologous recombination. CGN(-/-) are viable fertile, born expected mendelian ratios. Immunohistochemistry, immunofluorescence, electron microscopy permeability assays epithelial tissues show no cingulin labeling junctions,...
The treatment of celiac disease is based on lifelong withdrawal foods containing gluten. Unfortunately, compliance with a gluten-free diet has proved poor in many patients (mainly due to its low palatability), emphasizing the need for cereal varieties that are not toxic patients. In evolutionary terms, Triticum monococcum oldest and most primitive cultivated wheat. aim this study was evaluate toxicity T. small intestinal mucosa, using an vitro organ culture system.Distal duodenum biopsies 12...
Objectives To evaluate gastrointestinal permeability in primary biliary cirrhosis (PBC), using a sensitive method to detect epithelial damage, and correlate it with the Mayo score, histological stage, ascites, spontaneous bacterial peritonitis, endoscopic signs of portal hypertension Helicobacter pylori infection. Methods Fifty consecutive patients PBC 39 other aetiologies (non-PBC) were enrolled study. Coeliac disease was initially ruled out all participants. Permeability assessed sucrose...