A5063939706- Thyroid Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Head and Neck Anomalies
- Salivary Gland Tumors Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Lung Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Ovarian cancer diagnosis and treatment
- Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Medical Imaging and Pathology Studies
- BRCA gene mutations in cancer
- Head and Neck Cancer Studies
- Neuroblastoma Research and Treatments
- Cancer-related Molecular Pathways
- Sarcoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Oral and Maxillofacial Pathology
- Ear and Head Tumors
- Radiomics and Machine Learning in Medical Imaging
- Pituitary Gland Disorders and Treatments
- Cardiac tumors and thrombi
- Head and Neck Surgical Oncology
Aziende Socio Sanitaria Territoriale Rhodense
2022
Synlab Czech (Czechia)
2020-2021
University of Lausanne
2015-2020
John Wiley & Sons (United States)
2017-2020
McGill University
2020
FORS – Swiss Centre of Expertise in the Social Sciences
2019-2020
Massachusetts General Hospital
2015-2020
The University of Texas MD Anderson Cancer Center
2019-2020
Università Cattolica del Sacro Cuore
2017-2020
Charles River Laboratories (Netherlands)
2018-2020
BACKGROUND Recent discussions have focused on redefining noninvasive follicular variant of papillary thyroid carcinoma (NI‐FVPTC) as a neoplasm rather than carcinoma. This study assesses the potential impact such reclassification implied risk malignancy (ROM) for diagnostic categories The Bethesda System Reporting Thyroid Cytopathology (TBSRTC). METHODS consisted consecutive fine‐needle aspiration biopsy (FNAB) cases collected between January 1, 2013 and June 30, 2014 from 5 academic...
Abstract BACKGROUND: At present, thyroid fine‐needle aspiration (FNA) specimens are diagnosed using a tiered classification scheme, with the most popular of these being 5‐tiered and 6‐tiered systems. In this study, authors present their institutional experiences 2 different systems evaluate efficacy based on surgical follow‐up. METHODS: Thyroid FNA corresponding resection were collected between 2007 2009. The following diagnostic categories used in both systems: unsatisfactory/nondiagnostic,...
Background: Phosphatase and tensin homolog deleted on chromosome ten (PTEN)-hamartoma tumor syndrome (PHTS) is a complex disorder caused by germline inactivating mutations of the PTEN suppressor gene. PHTS includes Cowden (CS), Bannayan-Riley-Ruvalcaba (BRRS), Proteus-like syndromes. Affected individuals develop both benign malignant tumors in variety tissues, including thyroid. This study to better characterize describe thyroid pathology within different entities this syndrome, examine...
Only few studies analysed the capability of cytology in detecting medullary thyroid cancer (MTC), and they reported a low accuracy this diagnostic technique. Recently, calcitonin (CT) measurement aspiration needle washout (FNA-CT) neck lesions has been as sensitive tool for MTC. The aim study is to compare sensitivity FNA-CT MTC assess cut-off value clinical practice.Thirty-eight from 36 patients were retrospectively studied, diagnosed treated four different centres. Furthermore, 52...
BACKGROUND Secondary neoplasms of the thyroid gland (SNTGs) are uncommon, and it is important to recognize them in fine‐needle aspiration biopsy (FNAB). METHODS The authors report a cohort 62 SNTGs from 7 institutions United States Europe. Patients were identified retrospectively by searching through medical records respective institutions. All initial diagnoses rendered FNAB. RESULTS represented 0.16% all FNABs more frequent among women (ratio men, 1.2:1.0). mean patient age was 59 years...
To compare mutation analysis of cytology specimens and (99m)Tc-MIBI thyroid scintigraphy for differentiating benign from malignant nodules in patients with a cytological reading follicular neoplasm.Patients ≥18 years age solitary hypofunctioning nodule (≥10 mm), normal thyrotropin calcitonin levels, diagnosis neoplasm were prospectively enrolled. Mutation performed subsequently operated on to confirm or exclude lesion. Mutations KRAS, HRAS NRAS BRAF translocations PAX8/PPARγ, RET/PTC1...
Thyroid fine-needle aspiration (FNA) is a reliable and cost-effective diagnostic tool for establishing the nature of thyroid nodules, although up to 30% FNAs are still classified as "indeterminate." Molecular testing could improve preoperative diagnosis, thereby reducing unnecessary surgery. In this multicenter prospective study authors investigated, using 7-gene assay, distribution impact BRAF, RAS, RET/PTC, PAX8/PPARg, most frequent genomic alterations occurring during oncogenesis.In...
BACKGROUND Molecular testing of cytological lung cancer specimens includes, beyond epidermal growth factor receptor ( EGFR ), emerging predictive/prognostic genomic biomarkers such as Kirsten rat sarcoma viral oncogene homolog KRAS neuroblastoma RAS [v‐ras] NRAS B‐Raf proto‐oncogene, serine/threonine kinase BRAF and phosphatidylinositol‐4,5‐bisphosphate 3‐kinase catalytic subunit α PIK3CA ). Next‐generation sequencing (NGS) other multigene mutational assays are suitable for specimens,...
Background The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) is a 6‐tier diagnostic category system with associated risks of malignancy (ROMs) and management recommendations. Submandibular gland fine‐needle aspiration (FNA) uncommon higher frequency inflammatory lesions relative proportion malignancy, this may affect the ROM subsequent management. This study evaluated application MSRSGC each 734 submandibular FNAs. Methods FNA cytology specimens from 15 international...
Poorly differentiated thyroid carcinoma (PDTC) is an uncommon and aggressive malignancy. Despite the significant clinical implications of a diagnosis PDTC, its cytomorphologic features have not been well defined. Statistical analysis was applied to series 40 PDTCs identify specific set that characterized these tumors on fine-needle aspiration biopsy (FNAB).In total, FNABs were highly diagnosed histologically as PDTC (19 insular carcinomas 21 noninsular carcinomas) comprised study group. A...
Cingulin (CGN) is a 140 kDa protein, which localized to the cytoplasmic region of vertebrate tight junctions (TJ), and regulates gene expression RhoA signaling in cultured cells. To investigate function CGN at organism level, we generated knockout (CGN(-/-)) mice by homologous recombination. CGN(-/-) are viable fertile, born expected mendelian ratios. Immunohistochemistry, immunofluorescence, electron microscopy permeability assays epithelial tissues show no cingulin labeling junctions,...
The main goals of the symposium entitled “Thyroid Fine‐Needle Aspiration: New Classifications and Interpretations” are presentation discussion thyroid fine‐needle aspiration terminologies most commonly used, an analysis their respective advantages limitations, a statement how ancillary techniques could reduce number indeterminate cases.