A5043611756- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Anomalies
- Salivary Gland Tumors Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Genetic factors in colorectal cancer
- Thyroid and Parathyroid Surgery
- Neuroendocrine Tumor Research Advances
- Cancer and Skin Lesions
- Medical Imaging and Pathology Studies
- Lymphoma Diagnosis and Treatment
- Soft tissue tumor case studies
- BRCA gene mutations in cancer
- Cervical Cancer and HPV Research
- Oral and Maxillofacial Pathology
- Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Immune Cell Function and Interaction
- Gastrointestinal disorders and treatments
- Breast Lesions and Carcinomas
- Ear and Head Tumors
- Thyroid Disorders and Treatments
- Urinary and Genital Oncology Studies
- Renal cell carcinoma treatment
- Organ Transplantation Techniques and Outcomes
Kuma Hospital
2016-2025
John Wiley & Sons (Germany)
2024
Osaka University
2006-2024
Center for Excellence in Education
2010-2024
Nagasaki University
2023
Kyorin University
2023
Japan Association for Development of Community Medicine
2022
Fukushima Medical University
2021
Shiga Medical Center
2011-2019
Kinan Hospital
2019
Background: The question of how to manage patients with low-risk papillary thyroid microcarcinoma (PTMC; T1aN0M0) has recently become an important clinical issue. Two Japanese centers have conducted prospective trials active surveillance (AS) for PTMC since the 1990s, reporting favorable outcomes. This policy thus seen gradual adoption worldwide avoid overtreatment. Not all PTMCs are suitable AS, however, and many physicians still hesitate apply management in daily practice. A task force on...
Background: It has been 30 years since the initiation of active surveillance (AS) for adult patients with low-risk papillary thyroid microcarcinoma (PTMC). This study compared long-term oncological outcomes who underwent AS or immediate surgery (IS). Methods: is a retrospective review extended follow-up data from enrolled in single-center, prospective observational Japan. In total, 5646 diagnosed PTMC at Kuma Hospital between 1993 and 2019 were this study. Of these, 3222 (AS group), whereas...
Although histologic definition of follicular thyroid lesions is readily available, application the diagnostic criteria and personal experience may lead to disagreement among pathologists. To investigate interobserver variation in assessment encapsulated lesions, eight pathologists (four American four Japanese) reviewed same hematoxylin eosin-stained slide each 21 cases showing encapsulation growth pattern. In 10% cases, there was complete agreement. At least seven agreed on diagnosis 29% at...
Abstract Chemokines and their receptors play key roles in leukocyte trafficking are also implicated cancer metastasis to specific organs. Here we show that mouse B16F10 melanoma cells constitutively express chemokine receptor CXCR3, its ligands CXCL9/Mig, CXCL10/IP-10, CXCL11/I-TAC induce cellular responses vitro, such as actin polymerization, migration, invasion, cell survival. To determine whether CXCR3 could a role lymph nodes (LNs), constructed with reduced expression by antisense RNA...
Recent studies have demonstrated that BRAFV600E mutation is a common event in papillary thyroid carcinoma and majority of these lesions shown direct relationship between aggressive characteristics, including worse patient prognosis. However, there are no from Japan regarding this issue large series with adequate postoperative follow-up periods. We investigated 631 patients having median periods 83 months. The prevalence was 38.4%, the rate higher larger than 1.0 cm but did not successively...
Gastrointestinal phenotype in cervical adenocarcinomas was examined by immunohistochemistry and correlated with morphologic features. Antibody panels included anti-MUC2, MUC6, CD10, chromogranin A (CGA) HIK1083. In addition, expression of p16INK4, a cyclin-dependent kinase inhibitor which is expressed variety high-risk HPV-related conditions, studied. total 94 invasive including 20 minimal deviation (MDAs) 72 situ (AIS) were examined. MDAs most frequently positive for HIK1083 and/or two...
The aim of this study was to evaluate the relationships among [18F]fluorodeoxyglucose ([18F]-FDG) uptake, Glut-1 and HK-II expressions, grade inflammation in resected lung lesions.Sixty patients had undergone preoperative 18F-FDG-PET imaging thoracotomy. For semiquantitative analysis 18F-FDG partial volume effect corrected maximum standardized uptake values (pSUVs) were calculated. Immunohistochemical staining performed specimens using anti-Glut-1, anti-HK-II, anti-proliferative cellular...
IgG4-related sclerosing disease is a new syndrome characterized by high serum IgG4 levels and increased IgG4-positive plasma cells in the involved organs. Recently first description was made our group of subsection Hashimoto's autoimmune thyroiditis (HT) patients showing indistinguishable histopathological features with disease, which termed as thyroiditis.The objective study analysis immunophenotypic 70 cases HT to clarify clinical characteristics thyroiditis.Thyroid tissue samples were...
Anaplastic thyroid carcinoma (ATC) has a very dire prognosis and no effective therapeutic strategies have been established for ATC patients, especially those with stage IVB or IVC. Our objective was to investigate the effectiveness of weekly paclitaxel administered as induction chemotherapy establish novel ATC.We performed by administration patients (nine patients) IVC (four disease. Clinical histological responses were assessed. Overall survival compared that (n = 50) 13) treated without...
CD8+ T cells have suppressor effector functions, but the mechanisms involved in generation of this activity are poorly understood. We report that natural killer (NK) an important role acquisition function. induce NK to produce transforming growth factor-beta (TGF-beta) which, turn, stimulates become suppressors antibody production. Using a monocyte-dependent and -independent method production, we first observed addition was required for optimal suppression. Next, determined interaction with...
Abstract The cribriform‐morular variant (C‐MV), an unusual and peculiar subtype of papillary thyroid carcinoma (PTC), has been observed frequently in familial adenomatous polyposis (FAP)‐associated also sporadic carcinoma. In this paper, five young women with the C‐MV PTC, aged 22–34 years at cancer diagnosis, are reported; two them had attenuated FAP. Grossly, one FAP‐associated tumour were multicentric others solitary. Histologically, tumours encapsulated exhibited a combination...
In 1987, Carney et al reported 11 thyroid tumors with the following features: circumscription or encapsulation, trabecular architecture intratrabecular hyalin and colloid, polygonal spindle cells, nuclei frequent grooves cytoplasmic inclusions, occasional psammoma bodies, a low mitotic rate. The neoplasms did not recur metastasize during follow-up period that averaged 10 years, they were titled hyalinizing adenomas. Subsequently, nuclear features of neoplasm led to introduction 2 modified...
Complement C4d deposition in graft capillaries has been reported to be associated with antibody-mediated rejection kidney and other solid organ transplantation. The correlation of deposits humoral liver transplants, however, is not well understood. We investigated the immunostaining pattern 34 patients whose biopsy was taken within first 3 postoperative weeks for suspected acute after ABO blood type-incompatible staining classified as positive (portal stromal staining), indeterminate...
Background. Operational tolerance is defined as long-term acceptance of a transplanted organ after complete cessation immunosuppression (IS), but may not always protect against antigen-dependent changes in graft morphology. Method. IS free patients living-donor liver transplantation (LDLT) underwent protocol biopsy (tolerance group [Gr-Tol]) and were evaluated for rejection fibrosis. The degree fibrosis was compared with those the on maintenance (Gr-IS) base line normal (Gr-BS). When...
Background Although the AB0 blood group is one of two major antigen systems relevance for transplantation in humans, there are still conflicting data concerning influence incompatibility on transplant outcome. This study investigated effect recipients bone marrow transplants from unrelated donors.Design and Methods We retrospectively analyzed 5,549 patients who underwent donors Japan Marrow Donor Program.Results Overall survival rates with minor mismatches were significantly lower than rate...
Follicular thyroid carcinoma (FTC) is divided into two categories: minimally and widely invasive FTC. Generally, the prognosis of FTC excellent, but patients showing certain characteristics have a dire prognosis. In this study, we investigated prognostic factors using series 292 patients. On multivariate analysis, extensive (4 or more) vascular invasion, age ≥ 45 years, tumor size > 4 cm were independent patient disease-free survival (DFS). Distant metastasis at diagnosis (M1) was strongest...
Papillary thyroid cancer occasionally occurs in women of childbearing age. As papillary microcarcinoma (PTMC) rarely grows or becomes clinically apparent, observation without surgery is an appropriate strategy for patients with low-risk PTMC. Human chorionic gonadotropin possesses weak thyroid-stimulating activity. The aim this study was to assess the effect pregnancy on PTMC.We studied 9 PTMC who became pregnant between 2005 and 2011. Twenty-seven age-matched nonpregnant female from a...
<h3>Background</h3> <i>FOXE1</i> and <i>NKX2-1</i> are two known genetic risk factors for the predisposition to sporadic papillary thyroid carcinoma (PTC) in Europeans, but their association other ethnicities is still unknown. <h3>Objective</h3> We aim examine of genes with Japanese PTC, which exhibits high <i>BRAF<sup>V600E</sup></i> mutation rate. <h3>Methods</h3> 507 PTC cases 2766 controls were genotyped rs965513 (<i>FOXE1</i>) rs944289 (<i>NKX2-1</i>). also examined mutational status....
PAPILLARY THYROID CARCINOMA (PTC) is a malignant epithelial tumor that exhibits follicular cell differentiation and characterized by distinctive nuclear features, including ground glass appearance, grooves, cytoplasmic inclusions, overlapping [1].PTC the most common type of thyroid carcinoma its incidence has been increasing around world due to widespread use ultrasonography-guided fine needle aspiration cytology for small lesions [2, 3].Small-sized PTC, measuring ≤ 10mm, referred as...