A5101954007- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Head and Neck Anomalies
- Cancer-related Molecular Pathways
- Ovarian cancer diagnosis and treatment
- Neuroendocrine Tumor Research Advances
- Acute Ischemic Stroke Management
- Pituitary Gland Disorders and Treatments
- BRCA gene mutations in cancer
- Thyroid Disorders and Treatments
- Genetic factors in colorectal cancer
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- S100 Proteins and Annexins
- Cancer Diagnosis and Treatment
- Biomarkers in Disease Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Voice and Speech Disorders
- Moyamoya disease diagnosis and treatment
- Gastric Cancer Management and Outcomes
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Function and Risk Factors
Kuma Hospital
2016-2025
Toyota Memorial Hospital
2015-2024
Wakaba Hospital
2022-2024
Yokkaichi Nursing and Medical Care University
2024
Shimada Municipal Hospital
2024
Saiseikai Central Hospital
2023
Ohkawara Neurosurgical Hospital
2023
The University of Tokyo
1999-2023
Azumi Hospital
2023
Hokkaido University
2014-2022
The recent prevalence of ultrasound-guided fine-needle aspiration biopsy has resulted in a marked increase the number patients with papillary microcarcinoma (maximum diameter, </= 10 mm) thyroid detected by this sophisticated tool. On other hand, it is debatable whether should always undergo surgery after diagnosis, because high incidence occult carcinoma been observed autopsy studies. Thus, we proposed observation without surgical therapy as treatment option 732 diagnosed above technique...
We showed previously that subclinical low-risk papillary thyroid microcarcinoma (PTMC) could be observed without immediate surgery. Patient age is an important prognostic factor of clinical carcinoma (PTC). In this study, we investigated how patient influences the observation PTMC.Between 1993 and 2011, 1235 patients with PTMC chose They were followed periodically ultrasound examinations. These enrolled in study. divided them into three subsets based on at beginning observation: young (<40...
The incidence of papillary microcarcinoma (PMC) the thyroid is rapidly increasing globally, making management PMC an important clinical issue. Excellent oncological outcomes active surveillance for low-risk have been reported previously. Here, unfavorable events following and surgical treatment were studied.From February 2005 to August 2013, 2153 patients diagnosed with PMC. Of these, 1179 chose 974 immediate surgery. incidences these groups analyzed.In group, 94 underwent surgery various...
Background: The question of how to manage patients with low-risk papillary thyroid microcarcinoma (PTMC; T1aN0M0) has recently become an important clinical issue. Two Japanese centers have conducted prospective trials active surveillance (AS) for PTMC since the 1990s, reporting favorable outcomes. This policy thus seen gradual adoption worldwide avoid overtreatment. Not all PTMCs are suitable AS, however, and many physicians still hesitate apply management in daily practice. A task force on...
The 2015 American Thyroid Association thyroid cancer management guidelines endorse an active surveillance approach as alternative to immediate biopsy and surgery in subcentimeter nodules with highly suspicious ultrasonographic characteristics cytologically confirmed very low risk papillary (PTC). However, the provide no specific recommendations regard optimal selection of patients for approach. This article describes a risk-stratified clinical decision-making framework that was developed by...
Background: Detectable serum thyroglobulin (Tg) in patients with papillary thyroid carcinoma (PTC) after total thyroidectomy implies unsuccessful surgery, indicating a high risk of recurrence. Serum Tg kinetics such have not been extensively studied. We studied suppressed thyrotropin levels and undetectable anti-Tg antibody to minimize the effects these factors on values, evaluated relationship prognosis doubling-time. Methods: Between January 1998 December 2004, 1515 PTC underwent Kuma...
Papillary thyroid carcinoma (PTC) generally shows an excellent prognosis except in cases with aggressive backgrounds or clinicopathological features. Although the cause-specific survival (CSS) of PTC patients has been extensively investigated, overall (OS) these is unclear. We herein investigated both OS and CSS a large patient series.We enrolled 5897 who underwent initial surgery between 1987 2005 (658 males 5339 females; median age 51 years). Their postoperative follow-up period was 177...
Rapid increases in the incidence of thyroid carcinoma with stable mortality rates from have been reported many countries, and these are thought to be due mostly increased detection small papillary carcinomas (PTCs), including microcarcinomas (PMCs; i.e., PTCs ≤10 mm). Some researchers suggested that overdiagnosed overtreated. In Japan, active surveillance patients low-risk PMCs was initiated by Kuma Hospital (1993) Tokyo's Cancer Institute (1995) based on extremely higher incidences both...
Background: It has been 30 years since the initiation of active surveillance (AS) for adult patients with low-risk papillary thyroid microcarcinoma (PTMC). This study compared long-term oncological outcomes who underwent AS or immediate surgery (IS). Methods: is a retrospective review extended follow-up data from enrolled in single-center, prospective observational Japan. In total, 5646 diagnosed PTMC at Kuma Hospital between 1993 and 2019 were this study. Of these, 3222 (AS group), whereas...
In order to elucidate the clinical significance of erbB family, epidermal growth factor receptor (EGF-R), c-erbB-2, c-erbB-3 and c-erbB-4 in hepatocellular carcinoma (HCC), we investigated expression these proteins by means immunohistochemistry for HCC as well adjacent noncancerous lesions. EGF-R was expressed 68% examined showed correlation with proliferating activity, stage, intrahepatic metastasis differentiation. c-erbB-2 only 21% cases no relationships clinicopathological parameters....
Recent studies have demonstrated that BRAFV600E mutation is a common event in papillary thyroid carcinoma and majority of these lesions shown direct relationship between aggressive characteristics, including worse patient prognosis. However, there are no from Japan regarding this issue large series with adequate postoperative follow-up periods. We investigated 631 patients having median periods 83 months. The prevalence was 38.4%, the rate higher larger than 1.0 cm but did not successively...
This randomized clinical study was designed to evaluate the effect of probiotic intervention using lactobacilli on periodontal condition volunteers without severe periodontitis.Freeze-dried Lactobacillus salivarius WB21 (WB21)-containing tablets or a placebo were given in double-blind study. A total 66 finally enrolled and randomly assigned receive containing (6.7 x 10(8) CFU) with xylitol alone (placebo) three times day for 8 weeks. Periodontal parameters whole saliva samples obtained at...