A5077581552- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Dialysis and Renal Disease Management
- Ion channel regulation and function
- Heart Failure Treatment and Management
- Diabetes and associated disorders
- Nitric Oxide and Endothelin Effects
- Neuroendocrine Tumor Research Advances
- Parathyroid Disorders and Treatments
- Hormonal Regulation and Hypertension
- Erythrocyte Function and Pathophysiology
- Thyroid and Parathyroid Surgery
- Adrenal Hormones and Disorders
- Ophthalmology and Eye Disorders
- Head and Neck Anomalies
- Platelet Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Pituitary Gland Disorders and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Monoclonal and Polyclonal Antibodies Research
- Protein Kinase Regulation and GTPase Signaling
- T-cell and B-cell Immunology
- Blood properties and coagulation
- Adipokines, Inflammation, and Metabolic Diseases
Kuma Hospital
2001-2024
Center for Excellence in Education
2016-2024
Kansai Medical University
2004-2013
Kyoto University
1978-1998
Osaka Health Science University
1997
University of Toronto
1995-1996
Wellesley College
1995
Wellesley Institute
1995
Kyoto City Hospital
1984-1990
Suntory (Japan)
1990
Background: It has been 30 years since the initiation of active surveillance (AS) for adult patients with low-risk papillary thyroid microcarcinoma (PTMC). This study compared long-term oncological outcomes who underwent AS or immediate surgery (IS). Methods: is a retrospective review extended follow-up data from enrolled in single-center, prospective observational Japan. In total, 5646 diagnosed PTMC at Kuma Hospital between 1993 and 2019 were this study. Of these, 3222 (AS group), whereas...
SUMMARY Levels of platelet-derived microparticles (PMPs), platelet activation markers (P-selectin expressed on, or annexin V binding to, platelets (plt:P-selectin plt:annexin V, respectively)), chemokines (IL-8, monocyte chemotactic peptide-1 (MCP-1), and regulated on normally T-cell secreted (RANTES)), soluble P- E-selectins were compared in peripheral blood from diabetic control patients order to develop a better understanding their potential contribution vascular complications....
S100A12, also called EN-RAGE (extracellular newly identified receptor for advanced glycation end products binding protein) or calcium-binding protein in amniotic fluid-1, is a ligand RAGE. It has been shown that S100A12 induces adhesion molecules such as vascular cell molecule-1 and intercellular the endothelial mediates migration activation of monocytes/macrophages through RAGE infusion lipopolysaccharide into mice causes time-dependent increase plasma. Therefore, circulating may be...
Some investigators reported that among athyreotic patients on levothyroxine (LT4) monotherapy following total thyroidectomy, the with normal serum thyrotropin (TSH) levels had mildly low free triiodothyronine (fT3) levels, whereas suppressed TSH fT3 and strongly elevated levels. The objective of present study was to clarify which these three patient groups is closer their preoperative euthyroid condition.A 133 consecutive papillary thyroid carcinoma who underwent a thyroidectomy were...
<h3>Importance</h3> Patients with chronic kidney disease have impaired vitamin D activation and elevated cardiovascular risk. Observational studies in patients treated hemodialysis showed that the use of active sterols was associated lower risk all-cause mortality, regardless parathyroid hormone levels. <h3>Objective</h3> To determine whether receptor activators reduce events mortality without secondary hyperparathyroidism undergoing hemodialysis. <h3>Design, Setting, Participants</h3>...
We evaluated the plasma concentrations of soluble adhesion molecules and platelet-derived microparticles (PMP) in patients with non-insulin dependent diabetes mellitus (NIDDM) studied effect cilostazol on PMP generation. There were differences levels between NIDDM (N = 43) control subjects 30) (soluble thrombomodulin: 11.5+/-5.3 vs. 7.0+/-1.2 TU/ml, p<0.0001; vascular cell molecule-1: 708+/-203 492+/-113 ng/dl, intercellular molecules- 1: 274+/-65 206+/-48 P-selectin: 194+/-85 125+/-43...
We measured levels of platelet-derived microparticles (PMP), which have coagulative activity and are produced by platelet activation or physical stimulation, CD62P/CD63-positive platelets in patients with diabetes mellitus to determine their clinical significance effects on complications including diabetic nephropathy. also compared these before after administration the antiplatelet drug cilostazol. Plasma PMP were significantly higher than normal controls. CD62P-positive nephropathy without...
Left ventricular hypertrophy (LVH) commonly occurs in patients with end-stage renal disease (ESRD) and is an independent risk factor for cardiovascular events. Angiotensin II type 1 receptor (AT1-R) antagonists may be able to reverse LVH the hypotensive effect ESRD setting. Thirty chronically hemodialyzed uremic hypertension were randomly assigned receive AT1-R antagonist losartan (n = 10), angiotensin-converting enzyme (ACD) inhibitor enalapril or calcium amlodipine 10). mass (LVM) index...
Monocyte-derived microparticles play an important role in the pathogenesis of diabetic vasculopathy, and angiotensin II receptor blocker statin have been shown to a beneficial effect on angiopathies hypertension hyperglycemia patients with type 2 diabetes mellitus. However, interaction between statin, monocyte-derived atherosclerosis is poorly understood. The effects losartan simvastatin circulating concentrations microparticles, chemokines, soluble adhesion markers were studied hypertensive...
Endothelial cells, platelets, and oxidized LDL could play very important roles in the development of atherosclerosis diabetes patients. The levels plasma endothelial cell-derived microparticles (EDMP), platelet-derived (PDMP), platelet-P-selectin (plt-PS), soluble CD40 ligand (sCD40L), anti-oxidized antibody were measured compared to develop a better understanding their potential contribution diabetic vascular complications. concentrations EDMP, PDMP, plt-PS, sCD40L patients significantly...
To evaluate the effect of a thyroid stimulator on function in sera normal pregnant women, we measured thyroid-stimulating activity (TSA) using highly sensitive bioassay based cAMP accumulation cultured rat FRTL-5 cells. Serum was pretreated with 10% polyethylene glycol (PEG), and supernatant (PEG-pretreated serum) then used following studies. cells were preincubated 5H medium incubated for 2 h PEG serum, measured. All 11 patients untreated hyperthyroid Graves' disease strongly positive...
Conversion of T4 to T3 was studied in normal, Graves’, and neoplastic thyroid tissues obtained at surgery. Homogenates human follicular adenoma carcinomas were incubated with [125I]T4 dithiothreitol (DTT) 37 C for 60 min under N2 gas. formation assessed by measuring [125I]T3 formed, using paper chromatography. In the second series experiments, suspensions 100,000 × g pellet normal adjacent tumor Graves’ unlabeled DTT generated measured RIA. generation tissue dependent on incubation time,...
Journal Article Induction of Outer and Inner Ring Monodeiodinases in Human Thyroid Gland by Thyrotropin Get access HITOSHI ISHII, ISHII 1Second Division, Department Medicine, Kyoto University Faculty Medicine 54 Shogoin Kawaharacho, Sakyo-ku, 606; Kuma Hospital (F.M., K.K.) Shimoyamatedori, Chuo-ku, Kobe 650, Japan Search for other works this author on: Oxford Academic Google Scholar MITSUO INADA, INADA KIYOSHI TANAKA, TANAKA YASUO MASHIO, MASHIO KOICHI NAITO, NAITO MITSUSHIGE NISHIKAWA,...
Identifying patients at high risk of cardiovascular disease is important in managing undergoing hemodialysis.We evaluated a series prognostic values: flow-mediated dilation (FMD) and nitrogen-mediated (NMD), an index endothelium-dependent endothelium-independent function, respectively, ankle-brachial (ABI), brachial-ankle pulse wave velocity (baPWV) chronic hemodialysis.A cohort 199 was studied. At entry, these values were examined the significances investigated. In estimating significance...
Serum coenzyme Q<sub>10</sub> (CoQ<sub>10</sub>: 2-(3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26, 30,34,38-tetracontadecaenyl)-5,6-dimethoxy-3-methyl-1,4-benzoquinone, CAS 303-98-0) and cholesterol levels were measured to assess the effect of cholesterol-lowering therapy in patients with non-insulin-dependent diabetes mellitus (NIDDM). Twenty healthy volunteers, 97 NIDDM 2 familial hypercholesterolemia studied. None had overt heart failure or any other disease. Mean serum...
Subacute thyroiditis is generally believed to be induced by viral infection, and little attention has been paid anti-thyroid antibodies.Our study aimed assess the prevalence of antibodies in patients with subacute thyroiditis.Anti-thyroglobulin (TgAb) peroxidase (TPOAb) were measured 4 different immunoassay kits currently used 40 early phase thyroiditis.The proportion samples positive for TgAb was 52.5 ± 13.7% (mean kits), which significantly (p < 0.05) higher than that TPOAb (15.6 6.5%)....