A5012940591- Blood groups and transfusion
- Blood transfusion and management
- Hematopoietic Stem Cell Transplantation
- Radioactive contamination and transfer
- Blood donation and transfusion practices
- Erythrocyte Function and Pathophysiology
- Blood disorders and treatments
- Hepatitis B Virus Studies
- Platelet Disorders and Treatments
- Risk Perception and Management
- Radiation Dose and Imaging
- Radioactivity and Radon Measurements
- Hemoglobinopathies and Related Disorders
- Disaster Response and Management
- Neonatal Health and Biochemistry
- Acute Lymphoblastic Leukemia research
- Hepatitis C virus research
- Neonatal Respiratory Health Research
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Immunotherapy and Immune Responses
- Renal Transplantation Outcomes and Treatments
- Neutropenia and Cancer Infections
- Cytomegalovirus and herpesvirus research
- Thyroid Cancer Diagnosis and Treatment
Fukushima Medical University
2016-2025
Niigata University
2024
Tohoku University Hospital
2023
Kobe University Hospital
2023
Kurashiki Central Hospital
2023
Saitama Medical University
1987-2023
Japanese Society for Dialysis Therapy
2015-2023
Tokyo Metropolitan Children's Medical Center
2022
Japanese Red Cross Society, Japan
2000-2021
Fukushima Medical University Hospital
2007-2020
Although there are case reports of vertical transmission hepatitis C virus (HCV), it remains uncertain to what extent infected mothers transmit this their infants.We investigated the HCV from babies by analyzing RNA in blood. Three independent studies were performed. First, 7698 parturient women tested for anti-HCV antibodies; 53 positive. Their 54 infants (including one set twins) followed prospectively at least six months and disease studied. Third, families three HCV-infected examined...
BACKGROUND: Fetal genetic material is detectable in the maternal circulation and has been used for noninvasive prenatal diagnosis. However, few data are available concerning its quantity natural history during gestation. STUDY DESIGN AND METHODS: This study prospectively characterized kinetics of cellular cell‐free fetal DNA 25 healthy women after uncomplicated pregnancy. Real‐time kinetic PCR was to quantitate human Y‐chromosome sequences, liquid oligomer hybridization with 32 P‐labeled...
Myeloid-derived suppressor cells (MDSCs) have been identified in the majority of patients and experimental mice with tumors by their suppression T cell activation. MDSCs also reported to be associated chronic inflammation. In advanced cancer, helper (Th) balance tends shift from Th1 Th2 predominance, immune function, including cell-mediated immunity, is impaired cytokines produced cells. The present study examined correlations between MDSC levels inflammation, suppression, malnutrition, poor...
On March 11, 2011, the Great East Japan Earthquake occurred in Japan, with a nuclear accident subsequently occurring at Fukushima Daiichi Nuclear Power Plant. The disaster forced many evacuees to change particular aspects of their lifestyles. This study assessed hypothesis that evacuation may have increased risk hypertension among residents Fukushima. A longitudinal examined data collected from 31 252 Japanese participants aged 40 74 years sourced general health checkups conducted 13...
Background Although the AB0 blood group is one of two major antigen systems relevance for transplantation in humans, there are still conflicting data concerning influence incompatibility on transplant outcome. This study investigated effect recipients bone marrow transplants from unrelated donors.Design and Methods We retrospectively analyzed 5,549 patients who underwent donors Japan Marrow Donor Program.Results Overall survival rates with minor mismatches were significantly lower than rate...
Thyroid nodules and cancers are rare in children compared with adults. However, after the 1986 Chernobyl Nuclear Power Plant accident, a rapid increase childhood thyroid cancer was observed. To avoid any confusion misunderstanding of data obtained Fukushima 2011 nuclear baseline prevalence should be carefully assessed standardized criteria systematically, comprehensively applied to population perceived at risk.Under official framework Health Management Survey, thyroids were examined using...
The Fukushima Health Management Survey (FHMS) was established in response to the Daiichi Nuclear Power Plant accident on March 11, 2011. primary objectives of study are monitor residents' long-term health and promote their future well-being, determine effects low-dose radiation exposure. This special issue summarizes results current status FHMS discusses challenges directions FHMS. FHMS, a cohort all people who were residents Prefecture at time accident, consists Basic Survey, Thyroid...
BACKGROUND: Recent molecular studies of the RHD gene have revealed that D el individuals retain a grossly intact or portion in their genomes. No phenotype has yet been shown to induce primary secondary alloanti‐D immunization, however. CASE REPORT: A 67‐year‐old D– Japanese woman with history allosensitization from transfusion D+ red blood cells (RBCs) was negative for anti‐D at admission. After she received RBCs 19 apparently donors, developed an 8‐fold titer. The titer increased further...
Although a causal relationship between inflammation and innate immunity of cancer is more widely accepted today, many the precise cell mechanisms mediating this have not been elucidated. Th17 cells, which produce proinflammatory cytokine interleukin 17 (IL‑17), recognized as one key factors in regulation inflammatory bowel disease rheumatoid arthritis. This study demonstrated that, patients with various types gastrointestinal cancer, IL‑17 production was correlated myeloid‑derived suppressor...
After the Great East Japan Earthquake, over 160,000 residents near Fukushima Daiichi Nuclear Power Plant were forced to evacuate due a nuclear accident. Health problems in these evacuees have since become major issues. We examined association between evacuation and incidence of metabolic syndrome (METS) among Fukushima.We conducted cohort study aged 40-74 years without METS at time disaster Fukushima. Among 20,269 who met inclusion criteria before disaster, 8,547 (3,697 men 4,850 women;...
Ultrasonographic (US) screening for thyroid cancer was performed in the Fukushima Health Management Survey after 2011 Daiichi nuclear power station accident. Clinical characteristics of cancers screened by US among children and young adults during first 5 years accident were analyzed.To evaluate number detected age group within to compare basic clinical demographic patterns first- second-round examinations.In this observational study, 324 301 individuals 18 or younger at time included....
The 2011 Great East Japan Earthquake led to a subsequent nuclear accident at the Fukushima Daiichi Nuclear Power Plant. In its wake, we sought examine association between external radiation dose and thyroid cancer in Prefecture. We applied cross-sectional study design with 300,476 participants aged 18 years younger who underwent examinations October June 2015. Areas within Prefecture were divided into three groups based on individual doses (≥1% of 5 mSv, <99% 1 mSv/y, other). odds ratios...
After the Fukushima Daiichi Nuclear Power Plant accident in 2011, Health Management Survey (FHMS) was implemented Prefecture to promote long-term health care. The FHMS included thyroid ultrasound examination (TUE) for individuals aged ≤ 18 years, including fetuses at time of accident. However, may not have captured all cases cancer because it only followed up with examinees. To address this gap, we aimed merge individual-level information from national and local registries (CRs) determine...
Summary. Foetomaternal alloimmune thrombocytopenia (FMAIT) occurs when maternal antibodies of an antigen‐negative mother cause destruction sensitized foetal platelets. In Caucasian populations, 6–12% human platelet antigen (HPA)‐1a‐negative women develop anti‐HPA‐1a, and the incidence clinically affected cases is estimated to be 10–20% immunized women. This study was performed in order elucidate rate immunization, FMAIT likely outcome condition Asians. Excluding two or more pregnancies...