A5078260279- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Genomics and Rare Diseases
- Genetic factors in colorectal cancer
- Esophageal Cancer Research and Treatment
- Gastrointestinal Tumor Research and Treatment
- Biomedical and Engineering Education
- Medical Imaging and Pathology Studies
- Advanced Breast Cancer Therapies
- Radiation Dose and Imaging
- Cancer Cells and Metastasis
- Renal cell carcinoma treatment
- Risk Perception and Management
- Radioactive contamination and transfer
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Colorectal and Anal Carcinomas
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Estrogen and related hormone effects
- Thyroid Cancer Diagnosis and Treatment
Fukushima Medical University
2015-2025
Kyoto University Hospital
2022
Kyoto University
2022
Kyoto Prefectural University of Medicine
2014-2017
Linked color imaging (LCI) is a new image-enhanced endoscopy technique using laser light source to enhance slight differences in mucosal color. The aim of this study was compare the usefulness LCI and conventional white (WLI) for diagnosing Helicobacter pylori (H. pylori).We retrospectively analyzed images from 60 patients examined with WLI between October 2013 May 2014. Thirty had H. infections, other thirty tested negative after eradication therapy. Four endoscopists evaluated 2 types...
Background/Aims . The aim of this study was to evaluate the endoscopic recognition esophageal squamous cell carcinoma (ESCC) using four different methods (Olympus white light imaging (O-WLI), Fujifilm (F-WLI), narrow band (NBI), and blue laser imaging- (BLI-) bright). Methods. We retrospectively analyzed 25 superficial ESCCs that had been examined methods. Subjective evaluation provided by three endoscopists as a ranking score (RS) each image based on ease detection cancerous area. For...
After the Fukushima Daiichi Nuclear Power Plant accident in 2011, Health Management Survey (FHMS) was implemented Prefecture to promote long-term health care. The FHMS included thyroid ultrasound examination (TUE) for individuals aged ≤ 18 years, including fetuses at time of accident. However, may not have captured all cases cancer because it only followed up with examinees. To address this gap, we aimed merge individual-level information from national and local registries (CRs) determine...
Magnifying endoscopy with blue laser imaging (ME-BLI) for diagnosis of early gastric cancer (EGC) is as effective magnifying narrow-band (ME-NBI). However, there are different EGCs in microstructure visualization between ME-BLI and ME-NBI. This study aimed to clarify the pathological features EGCs, which was ME-NBI ME-BLI. were classified into groups A (irregular microsurface pattern (MSP) absent MSP ME-NBI), B two modalities), or C (absent according vessel plus surface classification. We...
Epithelial-mesenchymal transition (EMT) plays a crucial role in cancer metastasis. In this study, we evaluated the effect of heat treatment on tumor growth factor-β1 (TGF-β1)-induced EMT pancreatic cells and tried to ascertain mechanism related any observed effects. Human cell lines (BxPC-3, PANC-1 MIAPaCa-2) were stimulated by TGF-β1, for morphological changes using immunofluorescence EMT-related factors (i.e., E-cadherin, Vimentin, Snail or ZEB-1) RT-PCR. To examine EMT, heat-treated at...
Inherent variations in human leukocyte antigen (HLA) alleles have been revealed epidemiologically to influence the development of autoimmune diseases. HLA may thus also be associated with immune-related adverse events (irAEs), such as thyroid irAE.
Lenvatinib is an oral tyrosine kinase inhibitor of vascular endothelial growth factor receptors 1, 2, and 3, fibroblast 1 through 4, as well platelet-derived receptor α, RET, KIT. At present, lenvatinib used in the treatment thyroid cancer renal cell carcinoma. We herein report a case 67-year-old patient with squamous carcinoma unknown primary who was effectively treated lenvatinib. The initially diagnosed having undifferentiated cancer, after total thyroidectomy bilateral lymph node...
Somatic and germline variants are not distinguishable by circulating tumor DNA (ctDNA) testing without analyzing non-tumor samples. Although confirmatory is clinically relevant, the criteria for selecting presumed have been established in ctDNA testing. In present study, we aimed to evaluate prevalence of pathogenic clinical through their variant allele fractions (VAFs).A total consecutive 106 patients with advanced solid tumors who underwent (Guardant360®) between January 2018 March 2020...
2558 Background: Given the function of human leukocyte antigen (HLA) in immunity, variation HLA type could affect development immune-related adverse events (irAEs) that is induced by immune checkpoint inhibitors (ICIs). In this study, we examined whether types cancer patients be a marker for irAE thyroiditis. Methods: present case-control randomly selected 20 who received ICIs and developed thyroiditis (irAE group) 51 did not develop (No group). The were subdivided into 31 any irAEs other...