A5022854492- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Head and Neck Cancer Studies
- Metastasis and carcinoma case studies
- Helicobacter pylori-related gastroenterology studies
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Screening and Detection
- Alcohol Consumption and Health Effects
- Cancer Immunotherapy and Biomarkers
- Photodynamic Therapy Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic factors in colorectal cancer
- Palliative Care and End-of-Life Issues
- Genomics and Rare Diseases
- Colorectal and Anal Carcinomas
- Dysphagia Assessment and Management
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Tracheal and airway disorders
Kyoto University
2016-2025
Kyoto University Hospital
2016-2025
Kyoto Bunkyo University
2024
Kyoto University Institute for Chemical Research
2024
University of Yamanashi Hospital
2024
University of Oxford
2023
Kyoto City Hospital
2017-2021
The Japanese Society of Gastroenterological Surgery
2016-2021
Shizuoka Cancer Center
2021
Jikei University School of Medicine
2007-2020
Most of the esophageal squamous cell carcinomas (ESCCs) and cancers head neck (H&N) region are diagnosed at later stages. To achieve better survival, early detection is necessary. We compared real-time diagnostic yield superficial cancer in these regions between conventional white light imaging (WLI) narrow band (NBI) high-risk patients.In a multicenter, prospective, randomized controlled trial, 320 patients with ESCC were randomly assigned to primary WLI followed by NBI (n = 162) or 158)...
A newly developed narrow-band imaging (NBI) technique, in which modified optical filters were used the light source of a video endoscope system, was applied during colonoscopy clinical setting. This pilot study evaluated feasibility NBI system for evaluating colorectal lesions.A total 43 lesions 34 patients included study. The quality visualization and accuracy differentiation between neoplastic non-neoplastic using comparison with results from conventional chromoendoscopy.For pit pattern...
Purpose of the guidelines The primary objective these guidelines is to provide general clinicians with information that would guide them make informed choices available diagnosis/treatment strategies for esophageal cancer (intended malignant tumors epithelial origin, not any other non-epithelial esophagus or metastatic tumors). Furthermore, are also intended as an aid healthcare professionals than physicians, patients, and patients’ family members, obtain understanding fundamental...
treatment, thereby reducing the difference in treatment results among different institutions; (3) to reduce unnecessary costs and efforts; (4) help enable people undergo without anxiety.These guidelines provide only guidance on indications for do not restrict or prohibit use of any deviating from those described herein. ResponsibilitiesThe Japan Esophageal Society assumes responsibility content these guidelines.However, should be borne by doctor providing shall rest with Society.Basic...
PURPOSE: To investigate the efficacy and feasibility of concurrent chemoradiotherapy for locally advanced carcinoma esophagus. PATIENTS AND METHODS: Fifty-four patients with clinically T4 and/or M1 lymph node (LYM) squamous cell esophagus were enrolled. Patients received protracted infusion fluorouracil 400 mg/m 2 /24 hours on days 1 to 5 8 12, 2-hour cisplatin 40 8, radiation therapy at a dose 30 Gy in 15 fractions over 3 weeks. Filgrastim was prophylactically administered 35 patients. This...
Abstract BACKGROUND Head and neck squamous cell carcinoma typically is diagnosed at an advanced stage, the prognosis for patients with this type of malignancy poor. Detection these lesions earlier stage (e.g., as in situ) would be clear benefit to patients. However, it has been extremely difficult detect situ head mucosal sites during routine endoscopy, even after numerous passes endoscope through oral cavity pharynx. METHODS The current clinical investigation was performed endoscopic...
Endoscopic resection (ER) includes endoscopic mucosal (EMR), wherein the affected lesion is held or aspirated and resected with a snare, submucosal dissection (ESD), which refers to en bloc of an extensive using IT knife hook [1][2][3][4].Other treatments available include photodynamic therapy (PDT), argon plasma coagulation (APC), electromagnetic therapy.
The Japan Gastroenterological Endoscopy Society has developed endoscopic submucosal dissection/endoscopic mucosal resection guidelines. These guidelines present recommendations in response to 18 clinical questions concerning the preoperative diagnosis, indications, methods, curability assessment, and surveillance of patients undergoing for esophageal cancers based on a systematic review scientific literature.
<h3>Importance</h3> Immunotherapy using immune checkpoint inhibitors has been remarkably effective for treating multiple cancer types, and the gut microbiome is a possible factor affecting inhibitor efficacy. However, association between status of tumor microenvironment remains unclear. Short-chain fatty acids (SCFAs) are major end product metabolites produced by microbiota have wide-ranging impacts on host physiology. <h3>Objective</h3> To evaluate fecal plasma SCFAs in patients with solid...
After publication of the guidelines, Committee on Guidelines for Diagnosis and Treatment Esophageal Cancer Japan Society has taken initiative to continue review contents guidelines conduct public relations dissemination/utilization activities.A revision is planned approximately 5 years after this guideline.In addition, a prompt report will be made when results clinical study(ies) are published or in accordance with changes medical circumstances, such as health insurance coverage.
Some patients develop multiple squamous cell carcinomas (SCCs) in the upper aerodigestive tract, attributed to field cancerization; alcohol consumption has been associated with this process. We examined association between areas of dysplastic epithelium development SCC esophagus or head and neck cancer, as well smoking.We 331 early stage esophageal using Lugol chromoendoscopy evaluate esophagus. Patients then were assigned 3 groups, based on number Lugol-voiding lesions: A, no lesion; B, 1-9...
Background & AimsEsophagectomy is the standard treatment for stage I esophageal squamous cell carcinoma (ESCC). We conducted a single-arm prospective study to confirm efficacy and safety of selective chemoradiotherapy (CRT) based on findings from endoscopic resection (ER).MethodsWe performed patients with T1b (SM1–2) N0M0 thoracic ESCC December 2006 through July 2012; 176 underwent ER. Based ER, received following: no additional pT1a tumors negative margin lymphovascular invasion (group A);...
Abstract This is the second half of English edition Japanese Classification Esophageal Cancer, 12th Edition that was published by Japan Society in 2022.
Purpose: To assess the long-term toxicity after definitive chemoradiotherapy (CRT) for squamous cell carcinoma (SCC) of esophagus. Patients and Methods: newly diagnosed with SCC esophagus treated CRT between 1992 1999 in our institution were recruited from database on basis following criteria: age ≤ 75 years, performance status (PS; based Eastern Cooperative Oncology Group scale) 0 to 2, clinical tumor-node-metastasis system stage I IVA. The consisted two cycles cisplatin 40 mg/m 2 days 1 8,...