A5043504350- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Esophageal Cancer Research and Treatment
- Metastasis and carcinoma case studies
- Esophageal and GI Pathology
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Gastrointestinal disorders and treatments
- Lung Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Nutrition and Health in Aging
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Phytochemical Studies and Bioactivities
- Chromatography in Natural Products
- Neurofibromatosis and Schwannoma Cases
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Gastroesophageal reflux and treatments
- Sarcoma Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Cytokine Signaling Pathways and Interactions
- Multiple and Secondary Primary Cancers
Osaka University
2016-2025
The Japanese Society of Gastroenterological Surgery
2021-2024
Soka University
2017-2024
Osaka University Hospital
2021
Wakayama Medical University
2020
GTx (United States)
2020
Hamamatsu University School of Medicine
2020
Keio University
2020
Osaka City University
2014-2019
Chemotherapy Foundation
2016
Gastrectomy with D2 lymphadenectomy is the standard treatment for curable gastric cancer in eastern Asia. Whether addition of para-aortic nodal dissection (PAND) to stage T2, T3, or T4 tumors improves survival controversial. We conducted a randomized, controlled trial at 24 hospitals Japan compare alone plus PAND patients undergoing gastrectomy cancer.Between July 1995 and April 2001, 523 T2b, were randomly assigned during surgery (263 patients) (260 patients). did not permit any adjuvant...
Prior to publication of the Clavien-Dindo classification in 2004, there were no grading definitions for surgical complications either clinical practice or trials. This report establishes supplementary criteria this standardize evaluation postoperative trials.The Japan Clinical Oncology Group (JCOG) commissioned a committee. Members from nine study groups (gastric, esophageal, colorectal, lung, breast, gynecologic, urologic, bone and soft tissue, brain) specified experienced commonly their...
Abstract Purpose: To determine the relationship between resistance to chemotherapy and microRNA (miRNA) expression in esophageal cancer, we focused on miRNAs known be associated with maintenance of stem cell function. Experimental Design: Using 98 formalin-fixed, paraffin-embedded samples obtained from patients cancer who had received preoperative followed by surgery, measured levels several that are considered involved regulation function (e.g., let-7a, let-7g, miR-21, miR-134, miR-145,...
Objective: The aim of the study was to determine optimal extent lymph node dissection for 2 histological types esophagogastric junction (EGJ) tumors based on incidence metastasis in a prospective nationwide multicenter study. Background: Because most previous studies were retrospective, surgical procedure EGJ has not been standardized. Methods: Patients with cT2-T4 adenocarcinoma or squamous cell carcinoma located within 2.0 cm enrolled before surgery. Surgeons dissected all nodes...
•Pimitespib improved PFS compared with placebo in patients previously treated advanced GIST.•OS was pimitespib using the RPSFT model.•Exploratory pharmacogenomic analysis showed a benefit of irrespective KIT mutation status.•The safety profile acceptable, no deterioration quality life to placebo. BackgroundPrognosis gastrointestinal stromal tumors (GIST) refractory tyrosine kinase inhibitors (TKIs) is poor. This randomized, placebo-controlled, phase III trial evaluated efficacy and...
Tertiary lymphoid structures (TLSs) are ectopic aggregates in non-lymphoid tissues, which associated with improved prognosis some cancer types. This study aimed to investigate the clinical significance of TLSs oesophageal (EC).
The Japan Society of Clinical Oncology Practice Guidelines 2022 for gastrointestinal stromal tumor (GIST) have been published in accordance with the Minds Manual Guideline Development 2014 and 2017. A specialized team independent working group revision performed a systematic review. Since GIST is rare type tumor, clinical evidence not sufficient to answer several background questions. Thus, these guidelines, we considered that consensus among experts who manage GIST, balance between benefits...
T-cell infiltration into human cancer tissues can be a manifestation of host immune responses to cells. The present study was undertaken explore the clinicopathological significance intraepithelial CD8+ T cells using 371 consecutively sampled colorectal carcinomas. By univariate analysis, we noted that survival curves by became separated only after 1 2 years postoperation. Multivariate analyses revealed beneficial effect this factor becomes significant longer (more than year), but not...
Abstract Background Perioperative enteral immunonutrition is thought to reduce postoperative morbidity in patients undergoing major gastrointestinal surgery. This study assessed the clinical effects of preoperative well nourished with gastric cancer total gastrectomy. Methods Well primary cancer, fit for gastrectomy, were randomized either a control group regular diet, or an that received diet supplemented 1000 ml/day immunonutrients 5 consecutive days before The endpoint was incidence...
Abstract Purpose: Cisplatin-based chemotherapy is widely used for esophageal cancer, sometimes in combination with surgery/radiotherapy, but poor response to not uncommon. The aim of this study was examine whether miRNA expression useful predict the patients cancer. Experimental Design: Using pretreatment biopsy samples from 98 cancer who received preoperative chemotherapy, we measured level several miRNAs whose altered cisplatin-resistant cell lines compared those parent and examined...
Tumor-associated macrophages (TAMs) are well known to have distinct roles in tumor progression and metastasis. However, the role of TAMs chemoresistance has not been fully investigated. The aim this study is examine whether TAMs, especially M2 macrophages, associated with response chemotherapy esophageal cancers.Using 210 tissues from patients cancer who underwent surgery, we calculated number intratumoral CD68(+) CD163(+) CD8(+) lymphocytes using immunohistochemistry. CD68 CD163 were used...
Abstract Background The optimal surgical approach for treatment of oesophagogastric junction (OGJ) cancer is controversial. A randomized clinical trial (JCOG9502) comparing transhiatal (TH) and left thoracoabdominal (LTA) approaches was stopped after the first interim analysis owing to limited efficacy LTA resections. Complete 10-year follow-up data are now available. Methods Patients with histologically proven adenocarcinoma OGJ or gastric cardia oesophageal invasion 3 cm less were a TH...
Although multidrug resistance protein 2 (MRP2) confers chemoresistance in some cancer types, its implication on oesophageal squamous cell carcinoma (ESCC) remains unclear. We evaluated MRP2 expression by immunohistochemistry and RT–PCR using 81 resected specimens from ESCC patients who did or not receive neo-adjuvant chemotherapy (NACT), including 5-fluorouracil, doxorubicin, cisplatin (CDDP). Correlation between response to was also examined 42 pre-therapeutic biopsy samples eight lines....
S-1, an oral fluoropyrimidine, plus cisplatin (SP) is a standard regimen for advanced gastric cancer (AGC) in East Asia. To date, no studies have evaluated the efficacy and safety of trastuzumab combined with SP patients human epidermal growth factor receptor type 2 (HER2)-positive AGC. Patients HER2-positive AGC received S-1 (80–120 mg per day) orally on days 1–14, (60 m−2) intravenously day 1, (course 8 kg−1; course onward, 6 kg−1) 1 21-day cycle. The primary end point was response rate...
There is increasing evidence that the expression of microRNA (miRNA) in cancer associated with chemosensitivity but mechanism miRNA-induced chemoresistance has not been fully elucidated. The aim this study was to examine role extracellular miRNA response chemotherapy esophageal cancer. First, serum miRNAs selected by array measured quantitative reverse transcription-polymerase chain reaction 68 patients who received cisplatin-based relationship between and chemotherapy. levels 18 were...
Abstract BACKGROUND: Cisplatin reduces plasma ghrelin levels through the 5‐hydroxytryptamine (5‐HT) receptor. This may cause cisplatin‐induced gastrointestinal disorders and hinders continuation of chemotherapy. The authors this report conducted a prospective, randomized phase 2 trial to evaluate effects exogenous during cisplatin‐based METHODS: Forty‐two patients with esophageal cancer who were receiving neoadjuvant chemotherapy assigned either group (n = 21) or placebo 21). They received...
Circulating tumour DNA (ctDNA) is an emerging candidate biomarker for malignancies and may be useful monitoring the disease status of gastric cancer.We performed targeted deep sequencing plasma cell-free (cfDNA) by massively parallel in patients with tumours harbouring TP53 mutations. The quantitative values TP53-ctDNA during clinical course were compared status.Three out ten mutations primary showed detectable mutation levels preoperative cfDNA. Although cfDNA concentrations not always...