A5101460953- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Angiogenesis and VEGF in Cancer
- Lymphoma Diagnosis and Treatment
- Retinal and Optic Conditions
- Eosinophilic Disorders and Syndromes
- Estrogen and related hormone effects
- Glaucoma and retinal disorders
- Acute Myeloid Leukemia Research
- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- T-cell and Retrovirus Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immunotherapy and Immune Responses
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Viral-associated cancers and disorders
- Plant Molecular Biology Research
- Renal Transplantation Outcomes and Treatments
- Light effects on plants
- Blood Coagulation and Thrombosis Mechanisms
- Pancreatic function and diabetes
- Endometriosis Research and Treatment
- Blood Pressure and Hypertension Studies
Juntendo University Nerima Hospital
2015-2024
Ehime University
2023
Tokyo Medical University
2006-2019
National Hospital Organization
2009-2016
Kyoto University Hospital
2009-2016
Bhatia Hospital
2016
Yokohama City University Medical Center
2016
Niigata University Medical and Dental Hospital
2016
Yokohama City University
2016
Toranomon Hospital
2016
We studied 99 patients who were undergoing total knee arthroplasty (TKA) to determine the optimum protocol for administration of tranexamic acid (TNA) in order reduce blood loss. It decreased by more than 40% after TNA. The haemostatic effect was greatest when TNA given preoperatively and on deflation tourniquet. There no increase incidence adverse affects receiving TNA, compared with a control group. conclude that two injections one tourniquet, significantly loss without increasing risk...
T-cell infiltration into human cancer tissues can be a manifestation of host immune responses to cells. The present study was undertaken explore the clinicopathological significance intraepithelial CD8+ T cells using 371 consecutively sampled colorectal carcinomas. By univariate analysis, we noted that survival curves by became separated only after 1 2 years postoperation. Multivariate analyses revealed beneficial effect this factor becomes significant longer (more than year), but not...
Mutations of CCAAT/enhancer-binding protein alpha (CEBPAmu) are found in 10% to 15% de novo acute myeloid leukemia (AML) cases. Double-mutated CEBPA (CEBPAdm) is associated with a favorable prognosis; however, single-mutated (CEBPAsm) does not seem improve prognosis. We investigated CEBPAmu for prognosis 1028 patients AML, registered the Multi-center Collaborative Program Gene Sequencing Japanese AML. It was that basic leucine zipper domain (bZIP) strongly prognosis, but out bZIP not. The...
In Arabidopsis thaliana, a number of circadian-associated factors have been identified. Among those, TOC1 (TIMING OF CAB EXPRESSION 1) is believed to be component the central oscillator. member small family proteins, designated as PSEUDO-RESPONSE REGULATORS (APRR1/TOC1, APRR3, APRR5, APRR7, and APRR9). Nonetheless, it not very clear whether or APRR members other than APRR1/TOC1 are also implicated in mechanisms underlying circadian rhythm. To address this issue further, here we characterized...
In Arabidopsis thaliana, a number of clock-associated protein factors have been identified. Among them, TOC1 (TIMING OF CAB EXPRESSION 1) is believed to be component the central oscillator. member small family proteins, designated as ARABIDOPSIS PSEUDO-RESPONSE REGULATOR, including PRR1/TOC1, PRR3, PRR5, PRR7 and PRR9. It has not certain whether or other PRR members are also implicated in clock function per se. To clarify this problem, here we constructed double mutant line, which assumed...
Nucleophosmin1 (NPM1) mutations are the most frequently detected gene in acute myeloid leukemia (AML) and considered a favorable prognostic factor. We retrospectively analyzed prognosis of 605 Japanese patients with de novo AML, including 174 NPM1-mutated AML. Although AML showed high remission rate, this was not factor for overall survival (OS); is contrary to generally accepted guidelines. Comprehensive mutation analysis that codon R882 DNA methyltransferase 3A (DNMT3AR882 mutations) were...
In Arabidopsis thaliana, the transcripts of APRR1/TOC1 family genes each start accumulating after dawn rhythmically and one another at intervals in order APRR9→APRR7→APRR5→APRR3→APRR1/TOC1 under continuous light. Except for well-characterized APRR1/TOC1, however, no evidence has been provided that other are indeed implicated mechanisms underlying circadian rhythms. We here attempted to provide such by characterizing transgenic plants constitutively express APRR5 gene. The resulting...
Neoplasms putatively originating from precursor and mature natural killer (NK) cells are rare, their clinical features unclear. A nationwide survey was performed in Japan to clarify the of these neoplasms diagnosed between 1994 1998, data for 237 patients who met criteria putative NK cell-lineage were analyzed. Among them, 11 had myeloid/NK-cell acute leukemia, 15 blastic NK-cell lymphoma, 21 lymphoblastic 22 aggressive leukemia/lymphoma, 149 nasal-type lymphoma (123 nasal 26 extranasal) 19...
The complete genome sequence of Arabidopsis thaliana revealed that this higher plant has a tremendous number protein kinases. We recently isolated novel type kinase, named AtWNK1, which shows an in vitro ability to phosphorylate the APRR3 member APRR1/TOC1 quintet been implicated mechanism underlying circadian rhythms Arabidopsis. here address two issues, one general and specific, as kinase. first asked question how many WNK family members are present plant, then whether or not other also...
EphB4 and ephrinB2 expressions in ovarian cancers were studied to analyse EphB4/ephrinB2 functions against clinical backgrounds. dominantly localised cancer cells of all cases studied. Both the histoscores mRNA levels significantly increased with stages (I<II<III<IV, P<0.001) cancers, although there was no significant difference or according histopathological types. as well correlated corresponding each case (EphB4, P<0.001; ephrinB2, P<0.001). The 24-month survival rates 36 patients high...
<h3>Aim:</h3> To study alterations in choroidal blood flow (CBF) the foveal region after panretinal photocoagulation (PRP) patients with severe proliferative diabetic retinopathy. <h3>Methods:</h3> Seventeen eyes of 17 non-proliferative retinopathy (PDR) or non-high-risk PDR and no macular oedema before PRP were included. All underwent four sessions scatter PRP. We measured velocity (CBVel), volume (CBVol) CBF 1 month using a laser Doppler flowmetry. <h3>Results:</h3> Macular did not develop...
Angiogenesis is essential for development, growth and advancement of solid tumours. Interferon-gamma-inducible protein 10 (IP-10) regulates lymphocyte chemotaxis, mediates vascular pericyte proliferation acts as an angiostatic agent, thus inhibiting tumour growth. This prompted us to study the clinical implications IP-10 expression related angiogenesis in uterine cervical cancers. The levels decreased with advancement, prognosis 30 patients low cancers was poor (66%), whereas 24-month...
The European Treatment and Outcome Study (EUTOS) long-term survival (ELTS) score predicts disease-specific death in patients with chronic myeloid leukemia (CML) being treated imatinib during the phase (CP) of disease. However, it is unclear whether ELTS CML-related events or treatment responses. This study evaluated predictive value regarding prognosis response CML-CP. Clinical data were retrospectively obtained from enrolled CML Cooperative Group (CML-CSG), which included diagnosed CML-CP...
Vascular endothelial cell growth factor (VEGF)-C levels were significantly (P<0.05) increased in 24 out of 40 metastatic lymph node lesions uterine cervical cancers. The prognosis the patients with VEGF-C level was poor and 24-month survival rate 38%, while 16 no change 81%. There a significant (P<0.01) difference rates between two groups. This is novel, direct evidence that might contribute to aggressive lymphangitic metastasis cancers, increase from primary tumour be prognostic indicator.