Yuho Najima
A5075476949- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Neutropenia and Cancer Infections
- T-cell and B-cell Immunology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- Peroxisome Proliferator-Activated Receptors
- Gut microbiota and health
- Antifungal resistance and susceptibility
- Immunotherapy and Immune Responses
- Histone Deacetylase Inhibitors Research
- Mesenchymal stem cell research
- Renal Transplantation Outcomes and Treatments
- Protein Degradation and Inhibitors
- Polyomavirus and related diseases
- Fungal Infections and Studies
- Cytomegalovirus and herpesvirus research
- Cancer Genomics and Diagnostics
- Hemoglobinopathies and Related Disorders
- Blood disorders and treatments
Tokyo Metropolitan Komagome Hospital
2016-2025
Kyoto University
2023
Kanazawa University
2023
RIKEN Center for Integrative Medical Sciences
2009-2019
Hudson Institute
2018
John Wiley & Sons (United States)
2018
The University of Tokyo
2003-2005
CD32 and CD25, molecules specifically found in human leukemia stem cells, are promising targets for therapy.
Leptin–deficient ob/ob mice show many characteristics of obesity, including excess peripheral adiposity as well severe hepatic steatosis, at least in part, due to increased lipogenesis. Polyunsaturated fatty acids (PUFAs) are not only ligands for peroxisome proliferator–activated receptor (PPAR) α but also negative regulators lipogenesis, which is thought be mediated by the repression sterol regulatory element–binding protein (SREBP)–1. We have previously shown that disruption SREBP–1...
Whereas humanized mouse models have contributed significantly to human immunology research, T cells developing in thymic environment fail demonstrate HLA-restricted function. To achieve immune response, we created an immune-compromised non-obese diabetic/SCID/IL2rg null strain (NSG) with homozygous expression of HLA class I heavy chain and light (NSG-HLA-A2/HHD). Transplantation purified Lin−CD34+CD38− hematopoietic stem into NSG-HLA-A2/HHD newborns resulted the development CD4+ CD8+ TCRαβ+...
Allogeneic hematopoietic cell transplantation (HCT) improves outcomes for patients with AML harboring an internal tandem duplication mutation of
The tumor suppressor p53 is a transcription factor that activates or represses its target genes after various genotoxic stresses. We have previously shown sterol regulatory element-binding protein-1 (SREBP-1), key transcriptional regulator of triglyceride synthesis, and the lipogenic enzymes under control are markedly suppressed in adipocytes from genetically obese ob/ob mice. Here we demonstrate highly induced mice fed state, leading to negative regulation SREBP-1 thereby genes. In fact,...
In the opinion of European LeukemiaNet (ELN), nucleophosmin member 1 gene mutation (NPM1 mut)-positive acute myeloid leukemia (AML) with an fms-like kinase 3-internal tandem duplication (FLT3-ITD) allele ratio (AR) <0.5 (low AR) has a favorable prognosis, and allogeneic hematopoietic stem cell transplant (allo-HSCT) in first complete remission (CR1) period is not actively recommended. We studied 147 patients FLT3-ITD mutation-positive AML, dividing them into those low AR ≥0.5 (high AR),...
To investigate an up-to-date alternative donor selection strategy, we compared the transplantation outcomes of 8/8 and 7/8 allele–matched unrelated bone marrow (UBMT) with those umbilical cord blood (UCBT) redefined role UCBT extended analysis. Using Cox competing risk regression analyses, analyzed in adult patients acute lymphoblastic leukemia (ALL) myeloid (AML). A total 2472 first myeloablative transplantations between 2000 2010 were included (8/8 UBMT, 1001; 656; UCBT, 815). For chronic...
Mutations of CCAAT/enhancer-binding protein alpha (CEBPAmu) are found in 10% to 15% de novo acute myeloid leukemia (AML) cases. Double-mutated CEBPA (CEBPAdm) is associated with a favorable prognosis; however, single-mutated (CEBPAsm) does not seem improve prognosis. We investigated CEBPAmu for prognosis 1028 patients AML, registered the Multi-center Collaborative Program Gene Sequencing Japanese AML. It was that basic leucine zipper domain (bZIP) strongly prognosis, but out bZIP not. The...
BMT CTN 1506 ("MORPHO"; NCT02997202) was a randomized phase 3 study of gilteritinib compared to placebo as maintenance therapy after hematopoietic stem cell transplantation (HCT) for patients with FLT3-ITD-mutated acute myeloid leukemia (AML). A key secondary endpoint determine the impact on survival pre- and/or post-HCT measurable residual disease (MRD), determined using highly sensitive assay FLT3-ITD mutations. Generally, associated improved relapse-free (RFS) participants detectable...
Obesity is a major health problem in industrialized societies, and fatty liver disease (hepatic steatosis) common obese individuals. Oxidative stress originating from increased intracellular levels of acids has been implicated as cause hepatocellular injury steatosis, although the precise mechanisms remain to be elucidated. p53, widely known tumor suppressor, shown often activated stressed cells, inducing cell cycle arrest or death. Here we demonstrate that p53 involved molecular associated...
A pyrrolo-pyrimidine kinase inhibitor, RK-20449, eliminates chemotherapy-resistant human primary AML stem cells in vivo.
Abstract Acute graft-versus-host disease (aGVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Therefore, management aGVHD important for successful transplantation. Mucosal damage alteration the gut microbiota allo-HSCT are key factors in development aGVHD. We conducted prospective study to evaluate ability prebiotics, which can alleviate mucosal manipulate microbiota, mitigate posttransplantation complications, including...
Nucleophosmin1 (NPM1) mutations are the most frequently detected gene in acute myeloid leukemia (AML) and considered a favorable prognostic factor. We retrospectively analyzed prognosis of 605 Japanese patients with de novo AML, including 174 NPM1-mutated AML. Although AML showed high remission rate, this was not factor for overall survival (OS); is contrary to generally accepted guidelines. Comprehensive mutation analysis that codon R882 DNA methyltransferase 3A (DNMT3AR882 mutations) were...
Definite identification of the cell types and mechanism relevant to cardiomyogenesis is essential for effective cardiac regenerative medicine. We aimed identify populations that can generate cardiomyocytes clarify whether generation donor-marker(+) requires fusion between BM-derived cells recipient cardiomyocytes.Purified BM stem/progenitor from green fluorescence protein (GFP) mice were transplanted into C57BL/6 or cyan (CFP)-transgenic mice. Purified human hematopoietic stem (HSCs) cord...
Summary Haploidentical haematopoietic cell transplantation (haplo‐HCT) using post‐transplant cyclophosphamide (PTCY) as graft‐versus‐host disease (GVHD) prophylaxis is the standard of care for various haematological malignancies. The original PTCY dose after haplo‐HCT was 100 mg/kg, but no dose‐finding studies have been performed to identify optimal dose. We a retrospective analysis compare standard‐dose (100 mg/kg) with reduced‐dose (80 mg/kg): 969 in group and 538 group. As there...
Abstract Disturbed balance between immune surveillance and tolerance may lead to poor clinical outcomes in some malignancies. In paired analyses of adenocarcinoma normal mucosa from 142 patients, we found a significant increase the CD4/CD8 ratio accumulation regulatory T cells (Tregs) within adenocarcinoma. The increased frequency Tregs correlated with local infiltration extension tumor. There was concurrent maturation arrest, upregulation programmed death-1 expression, functional impairment...