A5024909015- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Intracranial Aneurysms: Treatment and Complications
- Glioma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Nutrition and Health in Aging
- Lung Cancer Diagnosis and Treatment
- Microtubule and mitosis dynamics
- Meningioma and schwannoma management
- Cancer Research and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Colorectal Cancer Surgical Treatments
- Cerebrovascular and Carotid Artery Diseases
- Neurofibromatosis and Schwannoma Cases
- Spinal Fractures and Fixation Techniques
- Nerve injury and regeneration
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Dysphagia Assessment and Management
- Tracheal and airway disorders
- Epigenetics and DNA Methylation
Kyoto University
2016-2025
Kyoto College of Medical Science
2021-2025
Kyoto University Hospital
2014-2024
The Japanese Society of Gastroenterological Surgery
2024
Yokohama City University
2023
Bundang Jesaeng Hospital
2023
University of Toronto
2023
Kobe City Medical Center General Hospital
2022
Hyogo Prefectural Amagasaki General Medical Center
2022
Kitano Hospital
2022
Sarcopenia or loss of skeletal muscle mass has been identified as a poor prognostic factor for wide variety diseases and conditions. We investigated whether preoperative sarcopenia is associated with postoperative complications in patients undergoing esophagectomy thoracic esophageal cancer.We retrospectively reviewed the medical records consecutive cancer who underwent between September 2005 July 2014 at Kyoto University Hospital. Skeletal was assessed using computed tomographic scans by...
Surgery is the standard of care for T1bN0M0 esophageal squamous cell carcinoma (ESCC), whereas chemoradiotherapy (CRT) a treatment option. This trial aimed to investigate noninferiority CRT relative surgery ESCC.Clinical ESCC patients were eligible enrollment in this prospective nonrandomized controlled study versus CRT. The primary endpoint was overall survival, which determined using inverse probability weighting with propensity scoring. consisted an esophagectomy 2- or 3-field lymph node...
434 Background: Neoadjuvant docetaxel, cisplatin, and 5-FU (DCF) has become the standard treatment for resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC) in Japan, based on result of JCOG1109. In this study, more non-cancer-related deaths were observed (CF) plus radiotherapy (CF-RT) arm compared to CF DCF arm. However, details these remain unclear. We aimed evaluate influence neoadjuvant therapies using data from Methods: analyzed patients' characteristics,...
Abstract Purpose: Fascin, an actin bundling protein, induces membrane protrusions and increased cell motility in various transformed cells. The expression of fascin epithelial neoplasms has been described only recently, the role esophageal squamous carcinoma (ESCC) is still unknown. Experimental Design: Paraffin sections 200 patients with ESCC were immunohistochemically investigated. levels mRNA 20 tissues compared that corresponding normal epithelium by semiquantitative reverse...
Prognostic factors for low-grade astrocytomas have been proposed, but optimal treatment remains controversial. Eighty-eight consecutive adult patients with supratentorial were retrospectively reviewed to determine specific influencing outcome. All underwent craniotomy (43 radical resections, 45 nonradical resections). Sex, age at diagnosis, preoperative Karnofsky performance status (KPS), tumor location, estimated extent of resection, radiation, chemotherapy, histological type, p53 status,...
In Brief Background: Completely laparoscopic gastrectomy with intracorporeal anastomosis was introduced to achieve safer and smaller scars. Although several reports have shown the feasibility of linear-stapled anastomosis, there are no studies a large number patients assessing long-term complications functional outcomes. Methods: This retrospective study included 345 who had intended undergo completely distal or total between September 2005 January 2012. evaluated both short- complications,...
<i>Objective:</i> We investigated the expression and function of hedgehog (Hh) pathway in human esophageal squamous cell carcinoma (ESCC). <i>Methods:</i> The Hh molecules were detected 34 ESCC lines by RT-PCR. Subsequently, we effects cyclopamine, a specific inhibitor pathway, on proliferation, migration invasion. Next, siRNA targeting Gli-1 examined. Immunohistochemically, was studied 104 specimens compared with clinicopathological characteristics patients....
Craniopharyngiomas are low-grade epithelial neoplasms occurring almost exclusively in the sellar/suprasellar region. Histologic malignancy is extremely rare; literature consists mostly of isolated case reports. Herein, we report 3 patients with craniopharyngiomas exhibiting histologic malignancy, 2 which received radiation therapy before its appearance. Hematoxylin and eosin-stained slides selected immunohistochemical stains were reviewed all cases. Microvessel density analysis was performed...
<i>Objective:</i> ATP-binding cassette, subfamily G, member 2 (ABCG2) is a new of the superfamily cassette transporter proteins and known to be not only membrane transporters implicated in multidrug resistance, but also molecular determinant side population phenotype, characteristics which are reminiscent stem cells. The aim current study was clarify significance ABCG2 expression esophageal squamous cell carcinoma (ESCC). <i>Methods:</i> We immunohistochemically...
Abstract In this study, we investigated the clinicopathologic significance of low-affinity p75 neurotrophin receptor (p75NTR; which is expressed in stem/progenitor cell fraction normal esophageal epithelial cells) 187 resected squamous carcinoma (ESCC) specimens and found that ∼50% ESCC p75NTR. Our investigation using lines showed p75NTR was intensely cells with high colony-forming capacity but they were sensitive to death on inhibition expression transient transfection small interfering RNA...
To elucidate the clinical significance of osteopontin and effect conditional down-regulation in esophageal squamous cell carcinoma (ESCC), we investigated expression tumors tested an inducible osteopontin-short-hairpin RNA (shRNA) vector ESCC line.Osteopontin mRNA was extracted from gene profiles 23 determined by cDNA microarray analyzed. Paraffin sections 144 were immunohistochemically investigated. Osteopontin protein 34 lines examined Western blot. A doxycycline-inducible...
Abstract Purpose: We previously reported that the expression of Aurora-A was frequently up-regulated in human esophageal squamous cell carcinoma (ESCC) tissues as well lines and up-regulation contributed to a poor prognosis. In this study, we assessed possibility suppression therapeutic target for ESCC using lines. Experimental Design: established subclones vector-based short hairpin RNA (shRNA). Then, investigated effect on proliferation cycle changes vitro. Next, chemosensitivity against...