A5002558811- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Colorectal Cancer Surgical Treatments
- Metastasis and carcinoma case studies
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Lung Cancer Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Head and Neck Cancer Studies
- Multiple and Secondary Primary Cancers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Surgical Simulation and Training
- Tracheal and airway disorders
- Pancreatic and Hepatic Oncology Research
- Diverticular Disease and Complications
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
Kyoto Prefectural University of Medicine
2025
University Hospital Kyoto Prefectural University of Medicine
2025
Kobe University Hospital
2002-2024
Tokyo Institute of Technology
2023
Tohoku University Hospital
2023
Osaka Dental University
2023
Kobe University
2013-2022
Tokyo-Kita Medical Center
2022
Miyazaki Prefectural Hospital
2019-2022
Hokkaido University
2021
Tumor associated macrophages (TAMs) are the most abundant cancer stromal cells educated by tumor microenvironment to acquire trophic functions facilitating angiogenesis, matrix breakdown and cell motility. have anti-inflammatory properties or "alternatively" activated (M2) phenotype expressing CD204 and/or CD163. To know role of TAMs in growth progression esophageal squamous carcinomas (ESCCs), we calculated intratumoral CD204, CD163 CD68 macrophage count (MϕC) CD34-positive microvessel...
Postoperative pulmonary complications (PPCs) after esophagectomy have been reported to occur in 15.9-30% of patients and lead increased postoperative morbidity mortality, prolonged duration hospital stay, additional medical costs. The purpose this retrospective cohort study was investigate the possible prevention PPCs by intensive preoperative respiratory rehabilitation esophageal cancer who underwent esophagectomy. subjects included 100 (87 males 13 females with mean age 66.5 ± 8.6 years)...
Surgery is the standard of care for T1bN0M0 esophageal squamous cell carcinoma (ESCC), whereas chemoradiotherapy (CRT) a treatment option. This trial aimed to investigate noninferiority CRT relative surgery ESCC.Clinical ESCC patients were eligible enrollment in this prospective nonrandomized controlled study versus CRT. The primary endpoint was overall survival, which determined using inverse probability weighting with propensity scoring. consisted an esophagectomy 2- or 3-field lymph node...
The expression levels of mRNAs for MDR1 (P-glycoprotein), multidrug resistance-associated proteins (MRP1, MRP2), and cytochrome P450 3A (CYP3A) in Caco-2 cells were quantitatively compared with those human duodenal enterocytes, normal colorectal tissues, adenocarcinomas. (passages 36–88) kindly supplied by several laboratories Japan. Human enterocytes obtained from five healthy male volunteers. Normal tissues adenocarcinomas simultaneously seven patients primary adenocarcinoma. MDR1, MRP1,...
<h3>BACKGROUND AND PURPOSE:</h3> IVIM MR imaging provides perfusion and diffusion information with a single diffusion-weighted image. We determined whether PP D differ among various types of head neck tumors. <h3>MATERIALS METHODS:</h3> The study cohort included 123 tumors: 30 SCCs, 28 benign 20 malignant SG tumors, 36 lymphomas, 9 schwannomas. values were by using b-values 0, 500, 1000 s/mm<sup>2</sup> based on the model. <h3>RESULTS:</h3> (lymphomas, 0.09 ± 0.04; 0.15 0.22 0.07) (0.47 0.07...
Abstract Endosomal toll-like receptor (TLR)-mediated detection of viral nucleic acids (NAs) and production type I interferon (IFN-I) are key elements antiviral defense, while inappropriate recognition self NAs with the induction IFN-I responses is linked to autoimmunity such as psoriasis systemic lupus erythematosus. Plasmacytoid dendritic cells (pDCs) specialized in robust secretion by engagement endosomal TLRs predominantly express sialic acid-binding Ig-like lectin (Siglec)-H. However,...
Abstract Dendritic cells (DCs) comprise several subsets that are critically involved in the initiation and regulation of immunity. Clec4A4/DC immunoreceptor 2 (DCIR2) is a C-type lectin receptor (CLR) exclusively expressed on CD8α − conventional DCs (cDCs). However, how Clec4A4 controls immune responses through function cDCs remains unclear. Here we show regulatory for activation impairs inflammation T-cell Clec4a4 −/− enhanced cytokine production priming following Toll-like (TLR)-mediated...
The aim of this study was to investigate PD-L1 expression and its association with prognosis in esophageal squamous cell carcinoma (ESCC) before after neoadjuvant chemotherapy (5-fluorouracil cisplatin, NAC-FP).Using a database 69 ESCC patients, we analyzed on tumor cells (TCs) immune (ICs), as well the density CD8+ tumor-infiltrating lymphocytes (TILs) pretreatment biopsy specimens-versus-surgical specimens resection. We determined prognostic significance these factors.The fraction...
Lactobacilli are important in intestinal homeostasis, which involves the regulation of immune function, digestive health, cholesterol absorption and tumor growth amongst others. Our previous investigations have suggested that oral intake heat-killed Lactobacillus brevis (L. brevis) SBC8803 (SBL88TM) suppresses dermatitis by modulating function an atopic mouse model. The aim present study was to investigate effect heat‑killed L. on skin hydration conditions humans. A randomized, double‑blind,...
Esophagectomy for esophageal cancer is a highly invasive procedure, and feeding jejunostomy tube (FJT) routinely placed to ensure adequate enteral nutrition. However, the effect of perioperative short-term FJT placement remains controversial, aim this study was assess risks benefits routine during esophagectomy determine parameters that can identify patients needing long-term FJT. This retrospective included 393 who had undergone with gastric reconstruction via posterior mediastinal route at...
Gastric carcinoma rarely affects young patients. This study was undertaken in order to clarify the clinicopathological features and prognosis of patients with gastric carcinoma.The resected 107 specimens from 105 younger than 30 years age were investigated using hematoxylin eosin stain.The male:female ratio 1:1.6. Histologically, poorly differentiated adenocarcinoma most common type (94/107, 87.9%) (P < 0.001). Most tumors located middle third stomach All had depressed lesions. The 5-year...