A5101635467- Graphene research and applications
- Carbon Nanotubes in Composites
- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Phase-change materials and chalcogenides
- Effects and risks of endocrine disrupting chemicals
- Semiconductor Quantum Structures and Devices
- Glass properties and applications
- Nanowire Synthesis and Applications
- Toxic Organic Pollutants Impact
- Mass Spectrometry Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Amino Acid Enzymes and Metabolism
- Chromatography in Natural Products
- Mechanical and Optical Resonators
- Semiconductor materials and devices
- Chalcogenide Semiconductor Thin Films
- Graphene and Nanomaterials Applications
- Polyamine Metabolism and Applications
- Analytical Chemistry and Sensors
- Atrial Fibrillation Management and Outcomes
- Quantum and electron transport phenomena
- Natural product bioactivities and synthesis
- Alzheimer's disease research and treatments
- Superconducting Materials and Applications
Ritsumeikan University
2016-2025
Osaka National Hospital
2024-2025
Osaka University
2013-2024
International Space Station
2024
Osaka Kyoiku University
2023
Eli Lilly (Japan)
2017-2021
Sakurabashi Watanabe Hospital
2012-2021
Akita University
2015-2021
Osaka Research Institute of Industrial Science and Technology
2011-2020
Fukuoka Technical High School
2020
Fluorinated organic compounds (FOCs), such as perfluorooctane sulfonate (PFOS), perfluoro-octanoate (PFOA), and sulfonylamide (PFOSA), are widely used in the manufacture of plastic, electronics, textile, construction material apparel, leather, upholstery industries. FOCs have been detected human blood samples. Studies indicated that may be detrimental to rodent development possibly by affecting thyroid hormone levels. In present study, we determined concentrations maternal cord Pregnant...
<h3>Importance</h3> Immunotherapy using immune checkpoint inhibitors has been remarkably effective for treating multiple cancer types, and the gut microbiome is a possible factor affecting inhibitor efficacy. However, association between status of tumor microenvironment remains unclear. Short-chain fatty acids (SCFAs) are major end product metabolites produced by microbiota have wide-ranging impacts on host physiology. <h3>Objective</h3> To evaluate fecal plasma SCFAs in patients with solid...
As clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain's own endogenous for neuroprotection. Recently, a hypothesis offered that modified reperfusion subsequent prolonged ischemic episode may also confer neuroprotection, phenomenon termed 'postconditioning'. Here we characterize both vivo and vitro models postconditioning brain offer data suggesting biological mechanism protection. Postconditioning treatment...
Abstract The 40 and 42 amino‐acid residue forms of amyloid beta (A β 1–40 A 1–42 ) in cerebrospinal fluid (CSF) have been proposed as potential biomarkers Alzheimer's disease (AD). Quantitative analyses peptides CSF relied almost exclusively on the use immunoassay‐based assays such enzyme‐linked immunosorbent assay (ELISA) procedure. However, due to ability readily self‐aggregate or bind other proteins glassware, are extremely challenging. Analyses further complicated by undergo...
Alzheimer's disease (AD) is an irreversible, progressive brain and can be definitively diagnosed after death through examination of senile plaques neurofibrillary tangles in several regions. It to expected that changes the concentration and/or localization low-molecular-weight molecules are linked pathological occur AD, determining their identity would provide valuable information regarding AD processes. Here, we propose definitive metabolic profiling using ultra-performance liquid...
Male Tsumura Suzuki obese diabetes (TSOD) mice spontaneously develop obesity and obesity-related metabolic syndrome. Gut dysbiosis, an imbalance of gut microbiota, has been implicated in the pathogenesis syndrome, but its mechanisms are unknown. Short-chain fatty acids (SCFAs) main fermentation products microbiota a link between host's physiology. Here, we investigated correlation among SCFAs, syndrome TSOD mice. We detected enriched levels Gram-positive bacteria corresponding decreases...
Abstract Apitherapy has become the focus of attention as a form folk and preventive medicine for treating certain conditions diseases well promoting overall health well‐being. In apitherapy, honey is therapeutic agent used dressing surgical wounds, burns or skin ulcers, dyspepsia, peptic ulcer, etc., because its antioxidant activity. Therefore, it important to determine antioxidants in by analytical techniques. present study, activities honeys from different floral sources were investigated...
We previously showed that male Tsumura Suzuki obese diabetes (TSOD) mice, a spontaneous mouse model of metabolic syndrome, manifested gut dysbiosis and subsequent disruption the type quantity plasma short-chain fatty acids (SCFAs), daily coffee intake prevented nonalcoholic steatohepatitis in this model. Here, we present preliminary study on whether its major components, caffeine chlorogenic acid, would affect disrupted SCFA profile TSOD which could lead to improvement liver pathology these...
Air-stable n-type carbon nanotube field-effect transistors (CNTFETs) were fabricated, with Si3N4 passivation films formed by catalytic chemical vapor deposition (Cat-CVD). Electrical measurements reveal that the p-type characteristics of CNTFETs are converted to after fabricating at 270°C. This indicates adsorbed oxygen on CNT sidewalls was removed during formation process films. In addition, source-drain current does not change over time under vacuum, or in air. Consequently, completely...
Curcuminoids are substances of great interest because their important pharmacological activities, particularly anti-inflammatory, anticarcinogenic, and anti-Alzheimer's activities. In this study, we report the first procedure effect processing for high, efficient, useful purification curcumin, demethoxycurcumin, bisdemethoxycurcumin from turmeric powder. Purification involves high-speed countercurrent chromatographic (HSCCC) separation these curcuminoids using a simple two-phase solvent...
The metabolism by human liver microsomes of several new illicit drugs, that is, N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3- carboxamide (ADB-FUBINACA), N-(1-amino-3-methyl-1-oxobutan-2-yl)-1- (4-fluorobenzyl)-1H-indazole-3-carboxamide (AB-FUBINACA), N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide (AB-PINACA), quinolin-8-yl 1-pentyl-(1H-indole)-3-carboxylate (QUPIC), 1-(5-fluoropentyl)-(1H-indole)-3-carboxylate (5 F-QUPIC) and...
The determination of polyamines and their N-acetylated forms was performed by ultraperformance liquid chromatography coupled with tandem mass spectrometry (UPLC–MS/MS). efficiently reacted 4-(N,N-dimethylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole (DBD-F) in 0.1 M borax (pH 9.3) at 60 °C for 30 min. resulting derivatives were analyzed electrospray ionization (ESI)-MS sensitively detected selected reaction monitoring (SRM). Furthermore, a rapid separation the polyamine within 10 min UPLC...
We have combined a graphene field-effect transistor (GFET) and surface acoustic wave (SAW) sensor on LiTaO3 substrate to create (GSAW) sensor. When SAW propagates in graphene, an acoustoelectric current (IA) flows between two attached electrodes. This has unique electrical characteristics, having both positive negative peak values with respect the electrolyte-gate voltage (VEg) solution. found that IA is controlled by VEg amplitude of SAW. It was also confirmed GSAW detects changes charge...