A5041753592- Effects and risks of endocrine disrupting chemicals
- Reproductive System and Pregnancy
- Growth Hormone and Insulin-like Growth Factors
- Hypothalamic control of reproductive hormones
- Endometriosis Research and Treatment
- Gynecological conditions and treatments
- Prenatal Screening and Diagnostics
- Ectopic Pregnancy Diagnosis and Management
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian function and disorders
- Uterine Myomas and Treatments
- Estrogen and related hormone effects
- Systemic Lupus Erythematosus Research
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular Health and Disease Prevention
- Herpesvirus Infections and Treatments
- Reproductive Biology and Fertility
- Pregnancy and preeclampsia studies
- Ion channel regulation and function
- Hormonal and reproductive studies
- Fetal and Pediatric Neurological Disorders
- Analytical Chemistry and Chromatography
- Pathogenesis and Treatment of Hiccups
- Parvovirus B19 Infection Studies
- Receptor Mechanisms and Signaling
Tokai University
2011-2021
John Wiley & Sons (United Kingdom)
2016-2019
Hudson Institute
2019
Tokai University Hospital
2014-2018
Keio University
1982-2016
Suzuki (Japan)
2016
National Center of Neurology and Psychiatry
2016
Kyoto University
2016
Tohoku University
2006-2015
Tokyo Women's Medical University
2010
The molecular pathogenesis of diabetes remains poorly understood because the genetic complexity disease. One possibly effective approach to elucidate is study an animal model with a similar phenotype. TSOD (Tsumura, Suzuki, Obese Diabetes) mouse, newly developed model, exhibits both and obesity marked hyperinsulinemia hypertrophy pancreatic islets might represent common form obese type 2 in humans. Phenotypic characterization revealed that mouse had insulin resistance impaired...
The role of extracellular Ca2+ in pituitary hormone release was studied primary cultures rat anterior cells. basal levels luteinizing (LH), follicle-stimulating (FSH), thyrotropin (TSH), and adrenocorticotropin (ACTH) secretion were independent concentration ([Ca2+]e). In contrast, the growth (GH) prolactin (PRL) showed dose-dependent increases with elevation [Ca2+]e, abolished by Ca2+-channel antagonists. Under Ca2+-deficient conditions, BaCl2 mimicked effects calcium on PRL GH but a marked...
Cabergoline is effective for hyperprolactinemic hypogonadism. However, the rate of cabergoline-induced pregnancy in women with prolactinoma remains unknown. Also unknown whether cabergoline can control tumor growth and thereby achieve successful patients macroprolactinomas.Eighty-five macroprolactinomas (n = 29) or microprolactinomas 56) received prospective, high-dose therapy infertility based on individual prolactin suppression and/or shrinkage. The included 31 bromocriptine-resistant, 32...
Although recent papers have suggested that psychological factors are implicated in the experience of infertility, few studies assessed this relationship a sample Japanese infertile women. This study was carried out order to clarify whether women emotional distress. A cross-sectional questionnaire performed assess states 101 compared 81 healthy pregnant The hospital anxiety and depression scale (HADS) profile mood (POMS) were administered. These questionnaires produced scores for...
Basal and receptor-regulated changes in cytoplasmic calcium concentration ([Ca2+]i) were monitored by fluorescence analysis individual rat pituitary gonadotrophs loaded with the calcium-sensitive dye indo-1. Most exhibited low amplitude spontaneous oscillations basal [Ca2+]i that interspersed quiescent periods abolished removal of extracellular Ca2+ or addition channel blockers. Such random fluctuations [Ca2+]i, which reflect operation a plasma membrane oscillator, not coupled to...
Epigenetic alteration is an emerging paradigm underlying the long-term effects of chemicals on gene functions. Various chemicals, including organophosphate insecticides and heavy metals, have been detected in human fetal environment. Epigenetics by DNA methylation histone modifications, through dynamic chromatin remodeling, a mechanism for genome stability To investigate whether such environmental may cause epigenetic alterations, we studied selected morphological changes heterochromatin...
Immune-mediated necrotizing myopathy (IMNM), also known as autoimmune myopathy, is a histologic entity characterized by marked necrosis in the absence of prominent lymphocytes.1 Risk factors or triggers for IMNM include statin treatment, cancer, and connective tissue disease (CTD).1,2 Although autoantibodies against signal recognition particle (SRP) 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) are regarded markers IMNM, they not always detected sera pathologically defined patients...
The purpose of this study was to report the 3-year experience a nationwide demonstration project introduce non-invasive prenatal testing (NIPT) maternal plasma for aneuploidy, and review current status NIPT in Japan.Tests were conducted detect aneuploidy high-risk pregnant women, adequate genetic counseling provided. clinical data, test results, pregnancy outcomes recorded. We discuss problems on basis published reports meta-analyses.From April 2013 March 2016, 30 613 tests at 55 medical...
Earlier studies in platelet aggregation have shown that females seemed to greater aggregability than males as detected by conventional aggregometry which used light transmission (LT), but controversy still remains. This study was performed determine whether sex difference exists using the recently developed laser scattering (LS) method, can detect small aggregates (i.e., two or three platelets). Blood drawn from healthy volunteers (10 male and 10 female follicular phase after menstruation),...
Monoclonal antibodies were raised against arachidonate 12-lipoxygenase using a partially purified enzyme from porcine leukocytes as an antigen.Immunohistochemical studies indicated selective localization of in the cytosol polymorphonuclear leukocytes.Two separate species antibody (lox-1 and lox-2) recognizing different sites protein utilized to develop method determine amount rather than activity enzyme.Fab fragment lox-2 was conjugated horseradish peroxidase, conjugate label bound...
There have been a few but not precise surveys of the current status traditional Japanese Kampo education at medical schools in Japan. Our aim was to identify problems and suggest solutions for standardized educational model all throughout We surveyed 80 Japan regarding eight items related teaching or studying medicine: (1) number class meetings, target school year(s), type classes; (2) presence absence full-time instructors; (3) curricula contents; (4) textbooks use; (5) desire textbooks;...
Abstract Objective To evaluate the reasons for nonreportable cell‐free DNA (cfDNA) results in noninvasive prenatal testing (NIPT), we retrospectively studied maternal characteristics and other details associated with results. Methods A multicenter retrospective cohort study pregnant women undergoing NIPT by massively parallel sequencing (MPS) failed cfDNA tests was performed between April 2013 March 2017. The women's data MPS were analyzed terms of characteristics, test performance, fetal...