A5060142740- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Telomeres, Telomerase, and Senescence
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Metal and Thin Film Mechanics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Semiconductor materials and devices
- Diet and metabolism studies
- Ion-surface interactions and analysis
- Cardiovascular Function and Risk Factors
- Angiogenesis and VEGF in Cancer
- Cardiac Fibrosis and Remodeling
- Diabetes Treatment and Management
- Apelin-related biomedical research
- Liver Disease Diagnosis and Treatment
- Signaling Pathways in Disease
- Diamond and Carbon-based Materials Research
- Metabolism, Diabetes, and Cancer
- Electron and X-Ray Spectroscopy Techniques
- Axon Guidance and Neuronal Signaling
- Antioxidant Activity and Oxidative Stress
- Peptidase Inhibition and Analysis
National Cerebral and Cardiovascular Center
2023-2024
Juntendo University
2021-2023
Shimizu (Japan)
2011-2023
Niigata University
2014-2022
Juntendo University Hospital
2021-2022
Yahoo (United Kingdom)
2021
Takayanagi Dental Clinic
2020
Providence College
2018
Research Applications (United States)
2018
Cohort (United Kingdom)
2018
Brown adipose tissue (BAT) is a highly vascularized organ with abundant mitochondria that produce heat through uncoupled respiration. Obesity associated reduction of BAT function; however, it unknown how obesity promotes dysfunctional BAT. Here, using murine model diet-induced obesity, we determined causes capillary rarefaction and functional hypoxia in BAT, leading to “whitening” phenotype characterized by mitochondrial dysfunction, lipid droplet accumulation, decreased expression Vegfa....
In mammals, aging is associated with accumulation of senescent cells. Stresses such as telomere shortening and reactive oxygen species induce "cellular senescence", which characterized by growth arrest alteration the gene expression profile. Chronological development age-related diseases, including heart failure, diabetes, atherosclerotic disease, studies have shown that cells has a causative role in pathology these disorders. Endothelial cell senescence been reported to develop failure...
Abstract It has been reported that accumulation of senescent cells in various tissues contributes to pathological aging and elimination (senolysis) improves age-associated pathologies. Here, we demonstrate inhibition sodium–glucose co-transporter 2 (SGLT2) enhances clearance cells, thereby ameliorating phenotypic changes. In a mouse model dietary obesity, short-term treatment with the SGLT2 inhibitor canagliflozin reduced senescence load visceral adipose tissue improved inflammation...
Although many animal studies indicate insulin has cardioprotective effects, clinical suggest a link between resistance (hyperinsulinemia) and heart failure (HF). Here we have demonstrated that excessive cardiac signaling exacerbates systolic dysfunction induced by pressure overload in rodents. Chronic hepatic plasma level elevation. In contrast, was upregulated chronic because of mechanical stretch-induced activation cardiomyocyte receptors upregulation receptor Irs1 expression. increased...
To identify a novel target for the treatment of heart failure, we examined gene expression in failing heart. Among genes analyzed, Alox15 encoding protein 12/15 lipoxygenase (LOX) was markedly up-regulated failure. determine whether increased 12/15-LOX causes established transgenic mice that overexpressed cardiomyocytes. Echocardiography showed developed systolic dysfunction. Cardiac fibrosis with advancing age and associated infiltration macrophages. Consistent these observations, cardiac...
The central nervous system is thought to influence the regulation of cardiovascular in response humoral and neural signals from peripheral tissues, but our understanding molecular mechanisms involved still quite limited.Here, we demonstrate a system-mediated mechanism by which brain-derived neurotrophic factor (BDNF) has protective effect against cardiac remodeling after myocardial infarction (MI). We generated conditional BDNF knockout mice, expression was systemically reduced, using...
Diabetes affects cardiac structure and function, it has been suggested that diabetes leads to cardiomyopathy. Arachidonate 12/15-lipoxygenase (LOX) play an important role in atherogenesis heart failure. However, the of 12/15-LOX diabetic cardiomyopathy not examined. In this study, we investigated effects on We created streptozotocin (STZ)-induced mice compared them with Alox15-deficient mice. Expression inflammatory cytokines such as tumor necrosis factor (TNF)-α nuclear (NF)-κB were...
Accumulating evidence has suggested a role for p53 activation in various age-associated conditions. Here, we identified crucial of endothelial the regulation glucose homeostasis. Endothelial expression was markedly upregulated when mice were fed high-calorie diet. Disruption improved dietary inactivation nitric oxide synthase that peroxisome proliferator-activated receptor-γ coactivator-1α skeletal muscle, thereby increasing mitochondrial biogenesis and oxygen consumption. Mice with...
Research Article27 May 2016Open Access Source DataTransparent process Follistatin-like 1 promotes cardiac fibroblast activation and protects the heart from rupture Sonomi Maruyama Department of Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School Medicine, Boston, MA, USA Search for more papers by this author Kazuto Nakamura Kyriakos N Papanicolaou Soichi Sano Ippei Shimizu Yasuhide Asaumi Maurice J van den Hoff Anatomy, Embryology Physiology, Academic Medical...
Abstract Accumulation of senescent cells in various tissues has been reported to have a pathological role age-associated diseases. Elimination (senolysis) was recently reversibly improve aging phenotypes without increasing rates cancer. We previously identified glycoprotein nonmetastatic melanoma protein B (GPNMB) as seno-antigen specifically expressed by human vascular endothelial and demonstrated that vaccination against Gpnmb eliminated Gpnmb-positive cells, leading an improvement...
There is increasing evidence that nutrient-sensing machinery critically involved in the regulation of aging. The insulin/insulin-like growth factor-1 signaling pathway best-characterized with an influence on longevity a variety organisms, ranging from yeast to rodents. Reduced expression receptor for this has been reported prolong lifespan; however, underlying mechanisms are largely unknown. Here we show haploinsufficiency Akt1 leads increase lifespan mice. (+/-) mice had lower body weight...