A5057979009- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Management and Research
- Diabetes Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Cardiac Fibrosis and Remodeling
- Cardiac Ischemia and Reperfusion
- Lipoproteins and Cardiovascular Health
- Lymphoma Diagnosis and Treatment
- Regulation of Appetite and Obesity
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Histiocytic Disorders and Treatments
- Virus-based gene therapy research
- Adrenal and Paraganglionic Tumors
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Cardiovascular Syncope and Autonomic Disorders
- Liver physiology and pathology
- Viral-associated cancers and disorders
- Hepatitis B Virus Studies
- Hormonal Regulation and Hypertension
Jikei University School of Medicine
2012-2017
Diabetes Australia
2017
Ehime University
1998
Diabetes affects cardiac structure and function, it has been suggested that diabetes leads to cardiomyopathy. Arachidonate 12/15-lipoxygenase (LOX) play an important role in atherogenesis heart failure. However, the of 12/15-LOX diabetic cardiomyopathy not examined. In this study, we investigated effects on We created streptozotocin (STZ)-induced mice compared them with Alox15-deficient mice. Expression inflammatory cytokines such as tumor necrosis factor (TNF)-α nuclear (NF)-κB were...
Abstract Background It is presently unclear whether glycemic variability (GV) associated with baroreflex sensitivity (BRS), which an early indicator of cardiovascular autonomic neuropathy. The present study the first to examine relationships between BRS and GV measured using continuous glucose monitoring (CGM). Methods This was a multicenter, prospective, open-label clinical trial. A total 102 patients type 2 diabetes were consecutively recruited for this study. assessed by measuring...
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are oral antidiabetic drugs that promote urinary glucose excretion. Conversely, they cause behavioural changes, such as hyperphagia, result in a positive energy balance. The relationship between homeostasis and SGLT2 inhibitors-induced changes remains unclear. Here we show ipragliflozin, inhibitor, time-dependently affects behaviour enhances expenditure normal type diabetic Goto-Kakizaki (GK) rats, using continuous telemetry. Alongside...
Background Increased short-term blood pressure (BP) variability on 24-hour ambulatory BP monitoring (ABPM) is known to be a risk factor for cardiovascular events. However, very few studies have evaluated the effect of salt restriction particularly in hypertensive patients with type 2 diabetes. This study aimed investigate systolic (SBP) variability. Methods and Results 10 diabetes not receiving antihypertensive agents were enrolled study. After admission, all received salt-restricted diet...
Not only within-day glycemic variability but also day-to-day is a risk factor for diabetic patients. However, the ways of controlling are unclear. We hypothesized that durability basal insulin plays an important role in type 2 diabetes patients, and we therefore aimed to evaluate whether glargine U300, which exhibits prolonged absorption compared with U100 same composition as U100, would lead improved variability.This was single-center, randomized, open-label, crossover study patients using...
Angiotensin receptor blockers (ARBs) are reported to provide direct protection many organs by controlling inflammation and decreasing oxidant stress. Pioglitazone, an anti-diabetic agent that improves insulin resistance, was also decrease protect against atherosclerosis. This study aimed evaluate the utility of combination therapy with both medicines from viewpoint anti-inflammatory effects.We administered candesartan (12 mg daily) pioglitazone (15 simultaneously for 6 months hypertensive...
Angiotensin receptor blockers (ARBs) are reported to provide direct protection many organs by controlling inflammation and decreasing oxidant stress in patients without arteriosclerosis. This study aimed evaluate (1) whether an ARB (candesartan) decreases values for inflammatory parameters hypertensive with type 2 diabetes mellitus of long duration accompanied arteriosclerosis (2) there any predictors which would receive the benefits organ candesartan. We administered candesartan therapy (12...
It remains unclear whether ambulatory blood pressure variability (BPV) contributes toward day-by-day BPV, despite the fact that not only but also BPV is reported to be a risk factor for type 2 diabetes patients. This study aimed determine association between and which especially distinguished diurnal nocturnal in Day-by-day were assessed 30 patients (aged 54±15 years; 87% men; glycated hemoglobin: 9.1±1.9%) inpatient settings. systolic was correlated significantly with (r=0.426, P=0.019),...
Aldosterone-producing adrenocortical carcinoma is a rare malignancy, which usually diagnosed by histopathological examination of the excised tumor. In inoperable cases, aldosterone-producing ACC immunohistochemical staining metastatic tumor for Cytochrome P450 (CYP) 11β has not previously been reported and even in that case adrenocortical-specific adrenal 4 binding protein/steroidogenic factor1 (Ad4BP/SF1) steroidogenic enzymes reported. We report 67-year-old Japanese woman with carcinoma....
慢性活動性Epstein-Barr (以下EB ) ウイルス感染症 (chronic active Epstein-Barr virus infection; 以下CAEBV) は, EBウイルスの再活性化によるさまざまな病態の総称であり, 単なる感染症ではなくEBウイルス関連リンパ増殖症 (EBV-LPD) である. 症例は44歳の女性. 難治性の咽頭痛を主訴に複数の医療機関を受診し, 診断が確定しないため当科紹介となる. 右の口蓋扁桃と梨状陥凹に白苔を伴う潰瘍性病変と肝機能異常を認めた. EBウイルスの抗体価の上昇, EBウイルスDNAの上昇, 病理組織学的検査より口腔咽頭病変の原因はCAEBVによるものと診断した. 点滴および経口ステロイドの使用により潰瘍性病変の進行は停止し, 肝機能異常の改善, EBウイルスDNAの減少を認めた. CAEBVは, EBウイルスによるリンパ増殖性疾患としてとらえられており予後は不良であるため, 今後は血液内科での化学療法を予定した. 本症例を経験し難治性の口腔咽頭病変ではCAEBVも鑑別する必要があると考えた.