A5061954888- Microtubule and mitosis dynamics
- Immune Cell Function and Interaction
- Salivary Gland Disorders and Functions
- Cancer Genomics and Diagnostics
- T-cell and B-cell Immunology
- Oral and Maxillofacial Pathology
- Genetic factors in colorectal cancer
- Cerebrovascular and Carotid Artery Diseases
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Chemokine receptors and signaling
- Cancer, Hypoxia, and Metabolism
- Neurological Disorders and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer-related gene regulation
- IL-33, ST2, and ILC Pathways
- Genomics and Chromatin Dynamics
- Click Chemistry and Applications
- BRCA gene mutations in cancer
- Neurological Disease Mechanisms and Treatments
- Chemical Synthesis and Analysis
- Cancer-related Molecular Pathways
- Bone Metabolism and Diseases
- DNA Repair Mechanisms
- Amyloidosis: Diagnosis, Treatment, Outcomes
Tokushima University
2016-2025
Institute of Biomedical Science
2017-2024
University of Virginia
2019-2020
Hiroshima University
2009-2017
Guilin Medical University
2016
Matrix Research (United States)
2015
Frontier Medical College
2008
Rutgers, The State University of New Jersey
2005
Rutgers New Jersey Medical School
2005
Shimane Prefectural Institute of Public Health and Environmental Sciences
1998
Matrix metalloproteinases (MMPs) are extracellular zinc-dependent endopeptidases involved in the degradation and remodeling of matrix physiological pathological processes. MMPs also have a role cell proliferation, migration, differentiation, angiogenesis, apoptosis. We previously identified cancer invasion-related factors by comparing gene expression profiles between parent highly invasive clone cells. metalloproteinase-13 (MMP-13) was as common up-regulated factors. Although MMP-13 slightly...
Epithelial–mesenchymal transition (EMT) is a crucial process in cancer progression that provides cells with the ability to escape from primary focus, invade stromal tissues and migrate distant regions. Cell lines lack E-cadherin show increased tumorigenesis metastasis, expression levels of Snail correlate inversely prognosis patients suffering breast or oral squamous cell carcinoma (OSCC). Moreover, recent studies have shown most EMT cases are regulated by soluble growth factors cytokines....
Background Periostin, IFN-induced transmembrane protein 1 (IFITM1) and Wingless-type MMTV integration site family, member 5B (Wnt-5b) were previously identified as the invasion promoted genes of head neck squamous cell carcinoma (HNSCC) by comparing gene expression profiles between parent a highly invasive clone. We have reported that Periostin IFITM1 HNSCC cells. Here we demonstrated Wnt-5b overexpression Moreover, stromelysin-2 (matrix metalloproteinase-10; MMP-10) was common up-regulated...
We previously showed that male Tsumura Suzuki obese diabetes (TSOD) mice, a spontaneous mouse model of metabolic syndrome, manifested gut dysbiosis and subsequent disruption the type quantity plasma short-chain fatty acids (SCFAs), daily coffee intake prevented nonalcoholic steatohepatitis in this model. Here, we present preliminary study on whether its major components, caffeine chlorogenic acid, would affect disrupted SCFA profile TSOD which could lead to improvement liver pathology these...
// Mariko Obayashi 1, * , Maki Yoshida 9, Takaaki Tsunematsu 2 Ikuko Ogawa 3 Tomonori Sasahira 4 Hiroki Kuniyasu Issei Imoto 5 Yoshimitsu Abiko 6 Dan Xu 7, 8 Saori Fukunaga 7 Hidetoshi Tahara Yasusei Kudo Toshitaka Nagao 9 Takashi Takata 1 Department of Oral and Maxillofacial Pathobiology, Institute Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan Molecular Pathology, Biosciences, The University Tokushima Graduate School, Tokushima, Center Clinical Examination, Hospital,...
We studied the associations of mental deterioration and blood pressure with severity location lesions in cerebral white matter 35 patients (27 men eight women) aged 52-84 (mean 70.9) years multiple lacunar infarcts; 21 had no dementia 14 were demented. Using magnetic resonance imaging to evaluate lesion severity, we determined that demented more severe than nondemented patients; this difference was especially prominent for frontal lobe (p less 0.001). Score on rating scale Hasegawa et al...
Abstract Purpose: Head and neck squamous cell carcinoma (HNSCC) shows persistent invasion that frequently leads to local recurrence distant lymphatic metastasis. However, molecular mechanisms associated with of HNSCC remain poorly understood. We identified IFN-induced transmembrane protein 1 (IFITM1) as a candidate gene for promoting the by comparing expression profiles between parent highly invasive clone. Therefore, we examined role IFITM1 in HNSCC. Experimental Design: was lines cases...
Background Runt-related transcription factor 3 (RUNX3) is a tumor suppressor of cancer and appears to be an important component the transforming growth factor-beta (TGF-ß)-induced suppression pathway. Surprisingly, we found that RUNX3 expression level in head neck squamous cell carcinoma (HNSCC) tissues, which one most common types human cancer, was higher than normal tissues by previously published microarray dataset our preliminary study. Therefore, here examined oncogenic role HNSCC....
Background Metastasis to regional lymph nodes via lymphatic vessels plays a key role in cancer progression. Tumor lymphangiogenesis is known promote metastasis, and vascular endothelial growth factor C (VEGF-C) critical activator of tumor during the process metastasis. We previously identified periostin as an invasion- angiogenesis-promoting head neck squamous cell carcinoma (HNSCC). In this study, we discovered novel for lymphangiogenesis. Methods Findings Periostin overexpression...
Abstract The aryl hydrocarbon receptor (AhR) pathway plays a key role in activator of NF-κB ligand (RANKL)–mediated osteoclastogenesis. However, the mechanism underlying regulation AhR expression osteoclasts and signaling through which controls osteoclastogenesis remain unclear. We found that bone marrow–derived was upregulated by RANKL at an earlier stage than signature osteoclast genes such as those encoding cathepsin K NFAT, cytoplasmic, calcineurin-dependent 1. In response to RANKL,...
Macrophages (MΦs) are critical regulators of immune response and serve as a link between innate acquired immunity. The precise mechanism involvement tissue-resident MΦs in the pathogenesis autoimmune diseases is not clear. Here, using murine model for Sjögren's syndrome (SS), we investigated role onset development autoimmunity. Two unique populations CD11bhigh CD11blow resident were observed target tissue SS model. Comprehensive gene expression analysis chemokines revealed effective...
Abstract Objective Recent studies have revealed that the ability of cancer cells to undergo intermediate state epithelial‐to‐mesenchymal transition (EMT), partial EMT (p‐EMT), poses a higher metastatic risk rather than complete EMT. Here, we examined prognostic value p‐EMT‐related genes in head and neck squamous cell carcinoma (HNSCC) by bioinformatic approaches. Materials methods We used RNA‐seq data 519 primary HNSCC cases obtained from TCGA database. compared expression tissues with...
Interrelationships among blood pressure (BP), sodium (Na), potassium (K), dietary protein, and serum cholesterol level (Chol) were examined in 62% (1120) of 1818 Japanese inhabitants both sexes aged over 30 years who lived a rural village Japan. Fasting single-spot urine specimens collected the morning to measure Na, K, urea nitrogen (UN), inorganic sulfate (SO4), creatinine (Cr). The Cr ratios UN, SO4, Na/K, SO4/UN analyzed by multiple regression analysis determine independent associations...
Cholangiocarcinoma (CCA) has an abundance of tumor stroma which plays important role in cancer progression via tumor-promoting signals. This study aims to explore the microRNA (miRNA) profile CCA-associated fibroblasts (CCFs) and roles any identified miRNAs CCA progression.miRNA expression profiles CCFs normal skin were compared by microarray. Identified downregulated their target genes confirmed real-time PCR. Their binding was a luciferase reporter assay. The effects conditioned-media (CM)...
Ameloblastin, the most abundant nonamelogenin enamel matrix protein, plays a role in ameloblast differentiation. Here, we found that ameloblastin was expressed osteosarcoma cells; to explore potential functions of osteoblasts, investigated whether this protein is involved osteogenic differentiation and bone formation on premise CD63, member transmembrane-4 glycoprotein superfamily, interacts with integrins presence ameloblastin. Ameloblastin bound CD63 promoted binding integrin β1. The...
Geminin, an essential factor for DNA replication, directly binds to the licensing Cdt1 and inhibits pre-replicative complex formation prevent re-replication. In G1, geminin levels are controlled by anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase complex, which targets proteasomal degradation allow formation. Conversely, from S G2, is stabilized due APC/C inhibition, ensuring inhibition of However, mitotic regulation has hitherto not been described. Here we show that Aurora-A...
Background: Metabolic syndrome is one of the most important health issues worldwide. Obesity causes insulin resistance, hyperlipidemia, diabetes, and various diseases throughout body. The liver phenotype, which called nonalcoholic steatohepatitis (NASH), frequently progresses to hepatocellular carcinoma. We recently established a new animal model, Tsumura-Suzuki obese diabetic (TSOD) mice, spontaneously exhibit obesity, NASH with nodules. Methods: examined effects coffee intake on conditions...