A5037478296- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Helicobacter pylori-related gastroenterology studies
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Screening and Detection
- Pancreatitis Pathology and Treatment
- Lymphoma Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Colorectal Cancer Surgical Treatments
- Diverticular Disease and Complications
- Synthetic Organic Chemistry Methods
- IL-33, ST2, and ILC Pathways
- Gallbladder and Bile Duct Disorders
- Tracheal and airway disorders
- Vascular Malformations and Hemangiomas
- Pediatric Hepatobiliary Diseases and Treatments
- Viral-associated cancers and disorders
- Inflammatory Bowel Disease
- CNS Lymphoma Diagnosis and Treatment
Mie University Hospital
2015-2024
Mie University
2015-2024
Showa Inan General Hospital
2023-2024
Daiichi-Sankyo (Japan)
2018-2023
University of Electro-Communications
2018-2020
The Japanese Society of Gastroenterological Surgery
2020
Weatherford College
2020
Daiichi Sankyo (Germany)
2020
Daiichi-Sankyo (South Korea)
2020
Karolinska Institutet
2013-2018
The Japan Gastroenterological Endoscopy Society has developed endoscopic submucosal dissection/endoscopic mucosal resection guidelines. These guidelines present recommendations in response to 18 clinical questions concerning the preoperative diagnosis, indications, methods, curability assessment, and surveillance of patients undergoing for esophageal cancers based on a systematic review scientific literature.
Interleukin 17 (IL-17) is a pleiotropic cytokine that acts on both immune and non-immune cells generally implicated in inflammatory autoimmune diseases. Although IL-17 as well their source, mainly but not limited to Th17 cells, also abundant the inflamed intestine, role of bowel disease remains controversial. In present study, by using knockout (KO) mice, we investigated colitis, with special focus macrophage subpopulations. Here show IL-17KO mice had increased susceptibility DSS-induced...
Abstract Intestinal fibrosis is a serious complication in inflammatory bowel disease (IBD). Despite the remarkable success of recent anti-inflammatory therapies for IBD, incidence intestinal and need resection have not significantly changed. To clarify contribution haematopoietic-derived cells fibrosis, we prepared bone marrow (BM) chimeric mice (chimeras), which were reconstituted with BM derived from enhanced green fluorescent protein (EGFP)-transgenic or CC chemokine receptor 2...
Artificial intelligence (AI) systems have shown favorable performance in the detection of esophageal squamous cell carcinoma (ESCC). However, previous studies were limited by quality their validation methods. In this study, we evaluated an AI system with videos simulating situations which ESCC has been overlooked.We used 17,336 images from 1376 superficial ESCCs and 1461 196 noncancerous normal esophagi to construct system. To record videos, endoscope was passed through esophagus at a...
Abstract Background and Aim: Various techniques using magnifying endoscopy (ME) have been developed to enhance images of early gastric cancer (EGC) demarcations, which are often obscure. We investigated four ME methods determine is most effective in enhancing the recognition EGC demarcations: conventional (CME), with narrow band imaging (NBI‐ME), enhanced‐magnification acetic acid (EME), NBI (NBI‐EME). Methods: Thirty‐seven successive patients having a total 40 EGCs participated...
A 59-year-old man with a history of chronic myelogenous leukemia underwent colonoscopy because altered bowel habit. Conventional showed reddish, irregular shaped, semipedunculated polyp in the rectum, approximately 10 mm diameter ([Fig. 1]). Magnifying endoscopy indigo carmine revealed smooth surface without mucosal pits 2]). narrow band imaging many microvessels congested network pattern 3]). colon cancer was considered by colonoscopic findings. However, histopathology biopsies inflammatory...
Reactive oxygen species (ROS) and reactive nitrogen (RNS) can play an important role in cellular injury carcinogenesis of gastric epithelial cells infected with Helicobacter pylori. 8-OH-deoxy guanosine (8-OHdG) 8-nitroguanine (8-NG) are markers for ROS- RNS-mediated DNA oxidation, respectively. In this study, damage mucosa was observed directly using a newly developed antibody to 8-NG clarify how H. pylori infection causes nitrative cells.Immunohistochemistry anti-8-OHdG anti-8-NG...
This study aimed to clarify whether pretreatment human equilibrative nucleoside transporter (hENT1) expressions in endoscopic ultrasonography-guided fine-needle aspiration biopsy (EUS-FNAB) specimens obtained from resectable, borderline and locally advanced unresectable pancreatic ductal adenocarcinoma (PDAC) are concordant with those the resected specimen after gemcitabine-based chemoradiotherapy (Gem-CRT) validate utility of hENT1 expression using EUS-FNAB samples as a prognostic marker.We...
One-step formation of the ansa-skeleton realized synthesis kendomycin, an ansa-type quinone methide. The Fischer carbene complex derived from ansa-chain portion was subjected to intramolecular Dotz benzannulation afford desired oxametacyclophane with exclusive regioselectivity. Subsequent Claisen rearrangement, ortho oxidation resulting phenol derivative, and mild transformation p-quinone methide on a silica gel plate furnished kendomycin.
BACKGROUND CD5‐positive (CD5 + ) diffuse large B‐cell lymphoma (DLBCL) is characterized by frequent central nervous system recurrence and a predominant activated B‐cell‐like nature. Primary DLBCL in sanctuary sites (DLBCL‐SS) also demonstrates these features, >70% of patients harbor myeloid differentiation primary response 88 ( MYD88 (L265P) CD79B mutations. The objective the current study was to elucidate possible relationship between CD5 DLBCL‐SS. METHODS MYD88, CD79B, CD79A , caspase...
The radiologic and endoscopic findings in six patients with anisakiasis of the colon were analyzed. diagnosis was based on demonstration Anisakis larvae at radiography or elevated serum levels antibodies to this parasite. All reported abdominal symptoms 12-23 hours after ingestion raw fish. Double-contrast barium enema examination, performed 2-4 days onset syptoms all patients, revealed that right side frequently affected by edema, which radiographically demonstrated as luminal narrowing...
A 65-year-old man was referred to our hospital with obstructive jaundice. Laboratory tests showed elevated levels of alkaline phosphatase (1932 U/L; normal range 35 – 104 U/L), γ-glutamyltransferase (1030 value < 39 and bilirubin (3.6 mg/dL; 1.2 mg/dL). The tumor antigen CA 19-9 also (226.4 37 U/L).
A highly potent, selective NaV1.7 inhibitor, DS-1971a, has been discovered. Exploration of the left-hand phenyl ring sulfonamide derivatives (I and II) led to discovery novel series cycloalkane with high inhibitory potency in vitro. As right-hand heteroaromatic affected mechanism-based inhibition liability CYP3A4, replacement this moiety resulted generation 4-pyrimidyl derivatives. Additionally, GSH adducts formation, which can cause idiosyncratic drug toxicity, was successfully avoided by...
Abstract Background Narrow-band imaging (NBI) highlights the surface structures and vessels of colorectal polyps is useful for determining polyp histology. The narrow-band international endoscopic (NICE) classification a diagnostic tool histology based on NBI without optical magnification. In this study, we aimed to investigate value each type NICE using endoscopy data accumulated in clinical setting. Methods Endoscopy 534 (316 patients) treated at our facility were retrospectively analyzed....