A5103084164- Immunotherapy and Immune Responses
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Platelet Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Chronic Lymphocytic Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Fungal Infections and Studies
- Renal Diseases and Glomerulopathies
- Orthopaedic implants and arthroplasty
- Complement system in diseases
- Neutropenia and Cancer Infections
- Orthopedic Infections and Treatments
- Immune cells in cancer
- Sepsis Diagnosis and Treatment
Mie University
2016-2025
Hokkaido Orthopedic Surgery Memorial Hospital
1998-2024
Tsu City College
1989-2023
Suzuka University of Medical Science
2021-2022
Mie University Hospital
2008-2021
John Wiley & Sons (United States)
2019
Hudson Institute
2019
Shimane University Hospital
2016
Suzuki (Japan)
2016
Nagano Prefectural Suzaka Hospital
2016
Detecting early gastric cancer is difficult, and it may even be overlooked by experienced endoscopists. Recently, artificial intelligence based on deep learning through convolutional neural networks (CNNs) has enabled significant advancements in the field of gastroenterology. However, remains unclear whether a CNN can outperform In this study, we evaluated performance detecting better than that endoscopists.The was constructed using 13,584 endoscopic images from 2639 lesions cancer....
Abstract Purpose: Preparative lymphodepletion, the temporal ablation of immune system, has been reported to promote persistence transferred cells along with increased rates tumor regression in patients treated adoptive T-cell therapy. However, it remains unclear whether lymphodepletion is indispensable for immunotherapy receptor (TCR) gene–engineered T cells. Experimental Design: We conducted a first-in-man clinical trial TCR gene-transduced transfer recurrent MAGE-A4–expressing esophageal...
Purpose To elucidate the management and outcomes of patients with extranodal natural killer/T-cell lymphoma, nasal type (ENKL), who were diagnosed between 2000 2013 in Japan. Patients Methods Data from 358 ENKL 31 institutes retrospectively analyzed. Results Patients' median age was 58 years, 257 (72%) had localized disease. The most common first-line treatment radiotherapy dexamethasone, etoposide, ifosfamide, carboplatin (RT-DeVIC) (66%) for L-asparaginase-containing chemotherapy (30%)...
This report addresses whether small molecules can deplete FoxP3-expressing regulatory T (T reg) cells, thereby augmenting antitumor immunity. Imatinib, a tyrosine kinase inhibitor of oncogenic BCR-ABL protein expressed by chronic myelogenous leukemia (CML) possesses off-targets including LCK in cells. We showed that imatinib-treated CML patients complete molecular remission (CMR) exhibited selective depletion effector reg (eT cells and significant increase effector/memory CD8+ while non-CMR...
The CHP‐HER2 vaccine, comprising truncated 146HER2 protein complexed with nanogels of cholesteryl pullulan (CHP), is a novel antigen vaccine that elicits 146HER2‐specific CD8 + and CD4 T‐cell immune responses in patients HER2‐expressing tumors. We analyzed the humoral vaccinated those plus granulocyte‐macrophage colony‐stimulating factor (GM‐CSF). was injected subcutaneously at dose 300 µg protein. Nine received alone over first four injections, followed by GM‐CSF or OK‐432, whereas six from...
Abstract Objective: Invasive Trichosporon infection has been increasingly recognized in patients with hematologic malignancies. Our study aims to clarify the clinical characteristics of this disease and factors influencing patient prognosis. Patients methods: We retrospectively analyzed 33 cases fungemia (TF) malignancies treated at our collaborating five hospitals Japan between 1992 2007. Results: The majority these had acute leukemia (82%), neutropenia (85%), a history intensive...
Despite the outstanding results generally obtained with imatinib mesylate (IM) in treatment of chronic myeloid leukemia (CML), some patients show a poor molecular response. To evaluate relationship between steady-state trough plasma IM concentration (IM-C(min)) and clinical response CML patients, we integrated data from six independent Japanese studies. Among 254 mean IM-C(min) was 1,010.5 ng/ml. Importantly, significantly higher who achieved major (MMR) than those did not (P = 0.002)....
It remains unclear whether the immunologic status of cells in peripheral blood can be used as a prognostic indicator response to treatment for patients with unresectable metastatic colorectal cancer (MCRC). We therefore investigated relationship between pretreatment 40 MCRC who planned receive first-line chemotherapy and their progression-free survival. Twenty-five immune cell subsets, including monocytic myeloid-derived suppressor (M-MDSC) effector memory T (TEM), were measured by...
Interleukin 17 (IL-17) is a pleiotropic cytokine that acts on both immune and non-immune cells generally implicated in inflammatory autoimmune diseases. Although IL-17 as well their source, mainly but not limited to Th17 cells, also abundant the inflamed intestine, role of bowel disease remains controversial. In present study, by using knockout (KO) mice, we investigated colitis, with special focus macrophage subpopulations. Here show IL-17KO mice had increased susceptibility DSS-induced...
Abstract Intestinal fibrosis is a serious complication in inflammatory bowel disease (IBD). Despite the remarkable success of recent anti-inflammatory therapies for IBD, incidence intestinal and need resection have not significantly changed. To clarify contribution haematopoietic-derived cells fibrosis, we prepared bone marrow (BM) chimeric mice (chimeras), which were reconstituted with BM derived from enhanced green fluorescent protein (EGFP)-transgenic or CC chemokine receptor 2...
Peripheral blood monocytes are common precursor cells of dendritic (DCs) and macrophages. We have searched for factors with the potential to regulate differentiation DCs When CD14 + cultured granulocyte–macrophage colony‐stimulating factor (GM‐CSF) interleukin (IL) 4, CD1a − population, which consists macrophages, was found in serum‐containing cultures but not serum‐free cultures. Addition IL‐6 receptor‐neutralizing monoclonal antibody (mAb) or gp130‐neutralizing mAb resulted a decreased...
Invasive fungal diseases (IFDs) are life-threatening events in patients with haematologic disorders, and the spectrum of aetiological pathogens continues to expand. This study aimed evaluate clinical utility a panfungal polymerase chain reaction (PCR) assay for management IFDs such patients.We prospectively analysed 273 consecutive blood samples from 64 risk episodes 51 disorders at high IFD who were treated our hospital between April 2007 October 2010.PCR-positive results obtained 18...
We searched for cytokines with the potential to support survival of human B-cell precursor acute lymphoblastic leukaemia (pre-B ALL) cells. 47 patients pre-B ALL were classified into four stages: stage I, CD19+CD10-CD20-; II, CD19+CD10+CD20-; III, CD19+CD10+CD20+cytoplasmic mu-heavy chain (cmu)-; IV, CD19+CD10+CD20+cmu. Interleukin (IL)-3 receptor alpha (IL-3Ralpha) was expressed in all stages, whereas expressions IL-7Ralpha and IL-2Ralpha pronounced stages IV respectively. Neither IL-3,...
Abstract Human Langerhans cells (LCs) are of hematopoietic origin, but cytokine regulation their development is not fully understood. Notch ligand Delta-1 expressed in a proportion the skin. Granulocyte-macrophage colony-stimulating factor (GM-CSF) and transforming growth factor-β1 (TGF-β1) also secreted We report here that Delta-1, concert with GM-CSF TGF-β1, induces differentiation human CD14+ blood monocytes into express LC markers: CD1a, Langerin, cutaneous lymphocyte-associated antigen,...