A5019930073- CNS Lymphoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Erythrocyte Function and Pathophysiology
- Viral-associated cancers and disorders
- Acute Myeloid Leukemia Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hemoglobinopathies and Related Disorders
- Glioma Diagnosis and Treatment
- Ocular Diseases and Behçet’s Syndrome
- Biochemical and Molecular Research
- Herpesvirus Infections and Treatments
- CAR-T cell therapy research
- Eosinophilic Disorders and Syndromes
- Single-cell and spatial transcriptomics
- PI3K/AKT/mTOR signaling in cancer
- Signaling Pathways in Disease
- Intracerebral and Subarachnoid Hemorrhage Research
- Chemokine receptors and signaling
- Hematopoietic Stem Cell Transplantation
- Metabolism and Genetic Disorders
- T-cell and Retrovirus Studies
- Cardiac Fibrosis and Remodeling
Baylor College of Medicine
2023-2025
Mie University
2017-2022
Yokkaichi Municipal Hospital
2021-2022
Keio University
2014
Abstract Hematopoietic stem cells (HSCs) are capable of regenerating the blood system, but instructive cues that direct HSCs to regenerate particular lineages lost injury remain elusive. Here, we show iron is increasingly taken up by during anemia and induces erythroid gene expression regeneration in a Tet2 -dependent manner. Lineage tracing reveals respond hemolytic increasing output. The number spleen, not bone marrow, increases upon these exhibit enhanced proliferation, differentiation,...
Abstract Intestinal fibrosis is a serious complication in inflammatory bowel disease (IBD). Despite the remarkable success of recent anti-inflammatory therapies for IBD, incidence intestinal and need resection have not significantly changed. To clarify contribution haematopoietic-derived cells fibrosis, we prepared bone marrow (BM) chimeric mice (chimeras), which were reconstituted with BM derived from enhanced green fluorescent protein (EGFP)-transgenic or CC chemokine receptor 2...
Targeting the dependency of MLL-rearranged (MLLr) leukemias on menin with small molecule inhibitors has opened new therapeutic strategies for these poor-prognosis diseases. However, rapid development inhibitor resistance calls combinatory to improve responses and prevent resistance. Here we show that leukemia stem cells (LSCs) MLLr acute myeloid (AML) exhibit enhanced guanine nucleotide biosynthesis, inhibition which leads differentiation sensitization inhibitors. Mechanistically, targeting...
Hematopoiesis was considered a hierarchical stepwise process but revised to continuous following single-cell RNA sequencing. However, the uncertainty or fluctuation of transcriptome dynamics during differentiation not considered, and dendritic cell (DC) pathway in lymphoid context remains unclear. Here, we identify human B-plasmacytoid DC (pDC) bifurcation as large fluctuating putative B/NK progenitor region by dry wet methods. By converting splicing kinetics into diffusion deep generative...
Abstract We investigated the involvement of CXCL12–CXCR4 interactions in human lymphohematopoiesis by coculture with telomerized stromal cells. CXCR4 expression was low CD34+CD38−CD45RA−CD10−CD7−CD19− immature hematopoietic stem/precursor cells (HSPCs) but higher CD34+CD38−CD45RA+CD10+CD7+/−CD19− early lymphoid precursors and even CD34+CD38+CD45RA+CD10+CD7−CD19+ pro-B Inhibition effect cell–produced CXCL12 an anti-CXCR4–blocking Ab suppressed generation CD45RA+CD10−CD7+CD19− T (ETPs)...
CD25 is expressed on leukemic cells in 10–20% cases of acute myeloid leukemia (AML), and its expression associated with poor prognosis. We reevaluated the relationship between leukemia-initiating cell (LIC) properties AML using a patient-derived xenograft model. divided lineage marker-negative (Lin–) CD34+CD38– or Lin–CD34+ from CD25-positive into -negative populations, then transplanted each population NOD.Cg-PrkdcscidIl2rgtm1Wjl/Sz mice. Leukemic engraftment was observed both populations...
BACKGROUND:Massive tongue hemorrhage in patients with hemophilia is a medical emergency because it can lead to airway obstruction. However, managing bleeding inhibitors more difficult than without inhibitors. We report case of life-threatening massive and retropharyngeal hematoma patient A who had CASE REPORT:The was 71-year-old man severe high-responding He admitted our hospital dysarthria dysphagia secondary hematoma. Although bypassing therapy started immediately after admission, he...
Crystal-storing histiocytosis (CSH) is characterized by the accumulation of large histiocytes with intracytoplasmic crystallized immunoglobulin and typically associated hematological malignancies. A 69-year-old man, who had a history left nephrectomy chemotherapy for renal pelvic cancer six years earlier, received CT scan every year thereafter small nodule was found in lower lobe his lungs two prior to current presentation. Because progression this pulmonary nodule, he underwent lobectomy on...
A 52-year-old male was diagnosed with diffuse large B-cell lymphoma (DLBCL) BCL2, BCL6, and MYC translocations (triple hit lymphoma). In addition to nodal, splenic, gingival lesions, bone marrow extensively involved cells (up 90% of the nucleated cells). Although he received eight cycles dose-adjusted (DA)-EPOCH-R (etoposide, prednisolone, vincristine, cyclophosphamide, doxorubicin, rituximab), his recurred shortly after completion planned therapy. His disease not controlled by additional...
Most patients with hereditary spherocytosis (HS) have a family history of disease, while those without such are difficult to diagnose. We herein report case HS no harboring novel heterozygous mutation SPTA1, c.2161G>A (p.E721K), and homozygous polymorphism UGT1A1*6. In silico analyses suggested that the might contribute pathogenesis HS. The coexistence Gilbert's syndrome increases risk gallstones. Therefore, splenectomy, alone or in combination cholecystectomy, is recommended. determination...
Acute retinal necrosis (ARN) is an infectious retinitis caused by varicella zoster virus (VZV), herpes simplex or cytomegalovirus. Without systemic therapy, ARN may progress bilaterally in seventy percent of unilateral patients. A 38-year-old-man was admitted to our hospital with Hodgkin's lymphoma and hemophagocytic lymphohistiocytosis. During the chemotherapy, left facial developed. He received valacyclovir for 14 days. After improvement blisters, he continued acyclovir as secondary...
Background Brain natriuretic peptide (BNP) is an important biomarker for patients with cardiovascular diseases, including heart failure, hypertension and cardiac hypertrophy. It also known that BNP levels are relatively higher in chronic kidney disease no disease; however, the mechanism remains unclear. Methods results We developed a reporter mouse occasionally found this promoter was activated specifically papillary tip of kidneys, its activation not accompanied by mRNA expression. No...
Richter’s syndrome (RS) of the central nervous system (CNS) is known to have an extremely poor prognosis. Ibrutinib has been reported some activity in patients with RS, despite its Although ibrutinib crosses blood-brain barrier, efficacy RS CNS involvement remains unknown. Here, we report a case isolated that was confirmed be clonally related chronic lymphocytic leukemia (CLL) by immunoglobulin heavy chain gene analysis. median survival CLL significantly shorter than unrelated CLL, patient...
Sézary syndrome is a rare leukemic type of cutaneous T-cell lymphoma characterized by the presence neoplastic T cells with cerebriform nuclei (Sézary cells) in skin, lymph nodes, and peripheral blood. Typical have CD3+CD4+CD8– phenotype; however, cases aberrant loss antigens on cells, especially critically important such as CD4, there possibility misdiagnosing disease or underestimating tumor burden disease. Here, we report case CD4/CD8 double-negative Most blood had lost CD4 expression,...
Vascular malformation occurs most frequently in the head and neck region, especially lips tongue, but reports of vascular buccal fat pad region are relatively rare. We report a case pad. A 64-year-old woman consulted our hospital because painless swelling right cheek. She presented with an elastic-soft, mobile subcutaneous mass, 20 mm diameter, anterior edge masseter muscle Magnetic resonance imaging showed wellcircumscribed mass front muscle. The signal intensity nearly equivalent to that...
At initial diagnosis, central nervous system (CNS) involvement in acute promyelocytic leukemia (APL) is rare. Here, we report a case of newly diagnosed APL with CNS that was successfully treated all-trans retinoic acid (ATRA)-combined chemotherapy. A 64-year-old woman referred to our hospital evaluate bleeding tendency, and she APL. Induction chemotherapy ATRA via nasogastric tube initiated under mechanical ventilation because respiratory failure disturbance consciousness. Although her...