A5100718058- Plant Molecular Biology Research
- Plant Stress Responses and Tolerance
- Genomics, phytochemicals, and oxidative stress
- Photosynthetic Processes and Mechanisms
- Plant nutrient uptake and metabolism
- Plant tissue culture and regeneration
- Plant Gene Expression Analysis
- Plant Reproductive Biology
- Plant Genetic and Mutation Studies
- Advanced biosensing and bioanalysis techniques
- Autophagy in Disease and Therapy
- Plant-Microbe Interactions and Immunity
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Polysaccharides and Plant Cell Walls
- Cellular transport and secretion
- Plant responses to water stress
- Histone Deacetylase Inhibitors Research
- Lipid metabolism and disorders
- Protein Degradation and Inhibitors
- Bioactive Compounds and Antitumor Agents
- Eicosanoids and Hypertension Pharmacology
- Effects of Radiation Exposure
- Plant Micronutrient Interactions and Effects
- Viral gastroenteritis research and epidemiology
The University of Texas Health Science Center at Houston
2021-2025
China Agricultural University
2014-2024
University of Science and Technology Beijing
2024
University of South China
2015-2024
Baylor College of Medicine
2021
Shantou University
2021
Huanggang Normal University
2019
Nanjing Medical University
2016
Shaanxi Normal University
2016
University of Kansas Medical Center
2016
Mitogen-activated protein kinase (MAPK) cascades play important roles in regulating plant growth, development, and responses to various environmental stimuli. We demonstrate that MKK9, an MKK, is upstream activator of the MPKs MPK3 MPK6 both vitro planta. Expression active MKK9 transgenic plants induces synthesis ethylene camalexin through activation endogenous kinases. As a consequence, transcription multiple genes responsible for biosynthesis, responses, biosynthesis coordinately...
Abstract Nitric oxide (NO) is a bioactive molecule that functions in numerous physiological and developmental processes plants, including lateral root development. In this study, we used biochemical genetic approaches to analyze the function of Arabidopsis thaliana mitogen-activated protein kinase 6 (MPK6) regulation NO synthesis response hydrogen peroxide (H2O2) during both mpk6 mutants studied, H2O2-induced nitrate reductase (NR) activity were decreased dramatically. Furthermore, one NR...
Abstract Osmoregulation is important for plant growth, development and response to environmental changes. SNF1-related protein kinase 2s (SnRK2s) are quickly activated by osmotic stress central components in abscisic acid (ABA) signaling pathways; however, the upstream required SnRK2 activation early still unknown. Here, we report a critical role B2, B3 B4 subfamilies of Raf-like kinases (RAFs) as well ABA Arabidopsis thaliana . RAFs phosphorylation SnRK2s. Analyses high-order mutants reveal...
Abstract Camalexin, a major phytoalexin in Arabidopsis thaliana, consists of an indole ring and thiazole ring. The is produced from Trp, which converted to indole-3-acetonitrile (IAN) by CYP79B2/CYP79B3 CYP71A13. Conversion Cys(IAN) dihydrocamalexic acid subsequently camalexin catalyzed CYP71B15. Recent studies proposed that Cys derivative, not itself, the precursor conjugates with IAN. nature derivative how it IAN forms remain obscure. We found protein accumulation multiple glutathione...
Doubled haploid technology has been widely applied to multiple plant species and is recognized as one of the most important technologies for improving crop breeding efficiency. Although mutations in MATRILINEAL/Zea mays PHOSPHOLIPASE A1/NOT LIKE DAD (MTL/ZmPLA1/NLD) Zea DOMAIN OF UNKNOWN FUNCTION 679 MEMBRANE PROTEIN (ZmDMP) have shown generate haploids maize, knowledge genetic basis induction (HI) remains incomplete. Therefore, cloning new genes underlying HI further elucidating its...
Germ cells are indispensable carriers of genetic information from one generation to the next. In contrast well-understood process in animals, on mechanism germ cell initiation plants is very limited. SPOROCYTELESS/NOZZLE was previously identified as an essential regulator diploid (archesporial cell) differentiation stamens and ovules Arabidopsis (Arabidopsis thaliana). Although SPOROCYTELESS (SPL) transcription activated by floral organ identity AGAMOUS epigenetically regulated SET DOMAIN...
Background: Accumulating evidences indicate that nanomedicines greatly decrease the side effects and enhance efficacy of colorectal cancer (CRC) treatment. In particular, use rectal delivery nanomedicines, with advantages such as fast therapeutic a diminishing hepatic first-pass effect, is currently emerging. Method: We established CRC targeted system, in which α-lactalbumin peptosomes (PSs) co-loaded microRNA (miR)-31 inhibitor (miR-31i) curcumin (Cur) were encapsuslated thiolated TEMPO...
Despite the abundance of phosphorus in soil, very little is available as phosphate (Pi) for plants. Plants often experience low Pi (LP) stress. Intensive studies have been conducted to reveal mechanism used by plants deal with LP; however, sensing and signal transduction pathways are not fully understood. Using in-gel kinase assays, we determined activities MPK3 MPK6 Arabidopsis thaliana seedlings under both LP Pi-sufficient (Murashige Skoog, MS) conditions. MKK9 mutant transgenic crossed...
Nuclear NAD + homeostasis governed by NMNAT1 prevents apoptosis in AML stem cells suppressing p53.
Previous physiological and pharmacological studies have suggested that the activity of phosphoinositide-specific phospholipase C (PI-PLC) plays an important role in regulating plant salt stress responses by altering intracellular Ca2+ concentration. However, individual members PLCs involved this process need to be identified. Here, function AtPLC4 response Arabidopsis seedlings was analysed. plc4 mutant showed hyposensitivity compared with Col-0 wild-type seedlings, hyposensitive phenotype...
Pigmentation development, is a complex process regulated by many transcription factors during development. With the development of RNA sequencing (RNA-seq), non-coding RNAs, such as miRNAs, lncRNAs, and circRNAs, are found to play an important role in function detection related regulation factors. In this study, we provided expression profiles ncRNAs melanocyte skin mice with black coat color white embryonic day 15 (E15) postnatal 7 (P7). The different were detected via RNA-seq also...
Targeting the dependency of MLL-rearranged (MLLr) leukemias on menin with small molecule inhibitors has opened new therapeutic strategies for these poor-prognosis diseases. However, rapid development inhibitor resistance calls combinatory to improve responses and prevent resistance. Here we show that leukemia stem cells (LSCs) MLLr acute myeloid (AML) exhibit enhanced guanine nucleotide biosynthesis, inhibition which leads differentiation sensitization inhibitors. Mechanistically, targeting...
Cell wall remodeling is important for plants to adapt environmental stress. Under salt stress, cortical microtubules undergo a depolymerization-reassembly process promote the biosynthesis of stress-adaptive cellulose, but regulatory mechanisms underlying this are still largely unknown. In study, we reveal that FERONIA (FER), potential cell sensor, interacts with COMPANION OF CELLULOSE SYNTHASE1 (CC1) and its closest homolog, CC2, two proteins required microtubule reassembly under Biochemical...
The production of transgenic sweetpotato (cv. Xushu 18) plants exhibiting enhanced salt tolerance using overly sensitive (SOS) genes was achieved through Agrobacterium tumefaciens-mediated transformation. A. tumefaciens strain EHA105 harbors a binary vector pCAMBIA3301 with SOS (SOS1, SOS2 and SOS3) bar gene. Selection culture conducted 0.3 mg L−1 phosphinothricin (PPT). A total 40 were produced from the inoculated 170 cell aggregates via somatic embryogenesis. PCR analysis showed that 37...
Leaf senescence is the final leaf developmental process that regulated by both intracellular factors and environmental conditions. The mitogen-activated protein kinase (MAPK) signaling cascades have been shown to play important roles in regulating senescence; however, component(s) downstream of MAPK are not fully understood. Here we showed transcriptions ZmMEK1, ZmSIMK1, ZmMPK3 were induced during dark-induced maize senescence. Furthermore, in-gel analysis revealed 42 kDa was activated....
DOES NOT MAKE INFECTION 2 (MtDMI2) is a Leu rich repeat-type receptor kinase required for signal transduction in the Medicago truncatula/Sinorhizobium meliloti symbiosis pathway. However, mechanisms through which MtDMI2 participates nodulation homeostasis are poorly understood. In this study, we identified MtPUB2—a novel plant U-box (PUB)–type E3 ligase—and showed that it interacts with MtDMI2. and MtPUB2 accumulation were shown to be similar various tissues. Roots of plants was silenced by...