A5081651628- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Adipokines, Inflammation, and Metabolic Diseases
- Neuropeptides and Animal Physiology
- Cancer-related molecular mechanisms research
- Digestive system and related health
- Cancer, Hypoxia, and Metabolism
- Nuclear Structure and Function
- Cancer and Skin Lesions
- FOXO transcription factor regulation
- Cancer Genomics and Diagnostics
- Congenital Diaphragmatic Hernia Studies
- Renal and related cancers
- Hedgehog Signaling Pathway Studies
- Adipose Tissue and Metabolism
- Cellular Mechanics and Interactions
- MicroRNA in disease regulation
- RNA Research and Splicing
- Protease and Inhibitor Mechanisms
- TGF-β signaling in diseases
- S100 Proteins and Annexins
Capital Medical University
2023
China Agricultural University
2019-2022
A certain number of epithelial cells in intestinal crypts are DNA damage resistant and contribute to regeneration. However, the cellular mechanism underlying regeneration remains unclear. Using lineage tracing, we show that marked by an Msi1 reporter (Msi1+) right above Lgr5high exhibit resistance. Single-cell RNA sequencing reveals Msi1+ heterogeneous with majority being stem (ISCs). The damage-resistant subpopulation is characterized low-to-negative Lgr5 expression more rapidly cycling...
Background: Brown adipose tissue (BAT) dissipates chemical energy as heat and has the potential to be a protective strategy prevent obesity. microRNAs (miRNAs) are emerging important posttranscriptional factors affecting thermogenic function of BAT. However, regulatory mechanism underlying miRNA-mediated metabolism in BAT is not fully understood. Here, we explored roles miR-22 thermogenesis metabolism. Methods: Using global conditional knockout mice vivo models primary brown adipocytes an...
Myoepithelial and luminal cells synergistically expand in the mammary gland during pregnancy, this process is precisely governed by hormone-related signaling pathways. The bone morphogenetic protein (BMP) pathway now known to play crucial roles all organ systems. However, functions of BMP remain unclear. Here, we found that BMPR1a upregulated hormone-induced Sp1 at pregnancy. Using a doxycycline (Dox)-inducible conditional knockout mouse model, demonstrated loss myoepithelium results...
The Mammary gland undergoes complicated epithelial remodeling to form lobuloalveoli during pregnancy, in which basal cells remarkably increase a basket-like architecture. However, it remains largely unknown how dormant mammary stem/progenitor involve lobuloalveolar development. Here, we show that
Abstract The +4 cells in intestinal crypts are DNA damage-resistant and contribute to regeneration. However, their exact identity the mechanism underlying cell-mediated regeneration remain unclear. Using lineage tracing, we show that marked by an Msi1 reporter ( + ) enriched at position exhibit damage resistance. Single-cell RNA sequencing reveals heterogeneous with majority being stem (ISCs). subpopulation of is characterized low-to-negative Lgr5 expression more rapidly cycling than high...